{
  "id": 21507,
  "label": "sick sinus syndrome 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024562",
  "properties": {
    "xrefs": [
      "GARD:0025432",
      "MEDGEN:325270",
      "OMIM:608567",
      "UMLS:C1837845"
    ],
    "synonyms": [
      "SCN5A sick sinus syndrome",
      "sick sinus syndrome 1",
      "sick sinus syndrome caused by mutation in SCN5A",
      "SSS1",
      "sick sinus syndrome, congenital",
      "sinus bradycardia syndrome, familial",
      "sinus node disease, familial, autosomal recessive",
      "sinus rhythm, congenital absence of"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Any sick sinus syndrome in which the cause of the disease is a mutation in the SCN5A gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13129,
      "label": "familial sick sinus syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4004,
        26601
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013663",
          "MEDGEN:573766",
          "MESH:C563907",
          "MedDRA:10040639",
          "OMIMPS:608567",
          "Orphanet:166282",
          "SCTID:233913007",
          "UMLS:C0340491",
          "icd11.foundation:1495462959"
        ],
        "synonyms": [
          "familial sinus node dysfunction",
          "hereditary sick sinus syndrome",
          "SSS1",
          "sick sinus syndrome 1, autosomal recessive"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sick sinus syndrome is a rare cardiac rhythm disease, usually of the elderly, characterized by electrocardiographic findings of sinus bradycardia, atrial fibrillation, atrial tachycardia sinus arrest, or sino-atrial block, and that manifest with symptoms like syncope, dizziness, palpitations, fatigue, or even heart failure. It results from malfunction of the cardiac conduction system, probably secondary to degenerative fibrosis of nodal tissue in the elderly or secondary to cardiac disorders in younger patients."
      },
      "child_count": 8,
      "reference_id": "MONDO:0012061"
    },
    {
      "id": 26602,
      "label": "SCN5A-related cardiac rhythm disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        26601
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "SCN5A-related cardiac rhythm disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heterogeneous collection of cardiac rhythm disorders caused by genetic variations in the SCN5A gene with autosomal dominant inheritance. Affected individuals are commonly reported to have unremarkable cardiac morphology and at least one cardiac rhythm phenotype that includes, but is not limited to, atrial fibrillation, sick sinus syndrome, progressive cardiac conduction disease, ventricular fibrillation, long QT syndrome, and Brugada syndrome."
      },
      "child_count": 6,
      "reference_id": "MONDO:1010181"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13129,
      "label": "familial sick sinus syndrome"
    },
    {
      "id": 26602,
      "label": "SCN5A-related cardiac rhythm disorder"
    }
  ]
}