{
  "id": 21519,
  "label": "von Willebrand disease (hereditary or acquired)",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024574",
  "properties": {
    "xrefs": [
      "GARD:0025434",
      "ICD10CM:D68.0",
      "ICD9:286.4",
      "MEDGEN:22686",
      "MESH:D014842",
      "NANDO:2200682",
      "NCIT:C68677",
      "SCTID:128105004",
      "UMLS:C0042974"
    ],
    "synonyms": [
      "VWD",
      "Von Willebrand Disease",
      "von Willebrand disorder",
      "von Willebrand's disease",
      "von Willebrand disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Hereditary or acquired coagulation disorder characterized by a qualitative or quantitative deficiency of the von Willebrand factor. The latter plays an important role in platelet adhesion. Signs and symptoms include bruises, nose bleeding, gum bleeding following a dental procedure, heavy menstrual bleeding, and gastrointestinal bleeding."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4359,
      "label": "coagulation protein disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2212",
          "GARD:0023096",
          "MEDGEN:108723",
          "MESH:D020147",
          "NCIT:C27215",
          "SCTID:86075001",
          "UMLS:C0600503"
        ],
        "synonyms": [
          "coagulation factor deficiency",
          "coagulation factor deficiency syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002242"
    }
  ],
  "children": [
    {
      "id": 19371,
      "label": "hereditary von Willebrand disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4360,
        20411,
        21519
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12531",
          "MEDGEN:1814986",
          "MESH:C531844",
          "MedDRA:10047715",
          "Orphanet:903",
          "SCTID:234446004",
          "UMLS:C5703318",
          "icd11.foundation:2112021600"
        ],
        "synonyms": [
          "vascular haemophilia",
          "vascular hemophilia",
          "von Willebrand disease",
          "von Willebrand disorder",
          "von Willebrand's-Jurgens' disease",
          "von Willebrand-Jurgens disease",
          "congenital von willebrand's disease",
          "hereditary von Willebrand disease",
          "hereditary von Willebrand disease (hereditary or acquired)",
          "congenital von willebrand disease",
          "von Willebrand's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hereditary von Willebrand disease (VWD) is a hereditary bleeding disorder caused by a genetic anomaly leading to quantitative, structural or functional abnormalities of the Willebrand factor (von Willebrand factor; VWF). Two major groups of VWF deficiency have been defined: quantitative and partial (type 1) or total (type 3), and qualitative (type 2) with several subtypes (2A, 2B, 2M, 2N)."
      },
      "child_count": 15,
      "reference_id": "MONDO:0019565"
    },
    {
      "id": 19919,
      "label": "acquired von willebrand syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4360,
        20034,
        21519
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111146",
          "GARD:0005573",
          "MEDGEN:543999",
          "MedDRA:10069495",
          "NANDO:1200899",
          "Orphanet:99147",
          "PMID:28028990",
          "SCTID:234451005",
          "UMLS:C0272362"
        ],
        "synonyms": [
          "acquired von Willebrand disease",
          "acquired von Willebrand disease (hereditary or acquired)",
          "acquired von willebrand disease",
          "Willebrand disease, acquired"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acquired von Willebrand syndrome (AVWS) is a bleeding disorder marked by the same biological anomalies as those seen in hereditary von Willebrand disease (VWD) but which occurs in association with another underlying pathology, generally in elderly patients without any personal or family history of bleeding anomalies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020460"
    }
  ],
  "roots": [
    {
      "id": 4359,
      "label": "coagulation protein disease"
    }
  ]
}