{
  "id": 21524,
  "label": "vulvar squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024609",
  "properties": {
    "xrefs": [
      "DOID:2101",
      "EFO:1000624",
      "GARD:0022005",
      "MEDGEN:79201",
      "NCIT:C4052",
      "Orphanet:494448",
      "SCTID:254895003",
      "UMLS:C0280856",
      "icd11.foundation:146824338"
    ],
    "synonyms": [
      "epidermoid carcinoma of the vulva",
      "epidermoid carcinoma of vulva",
      "epidermoid cell carcinoma of the vulva",
      "epidermoid cell carcinoma of vulva",
      "mammalian vulva squamous cell carcinoma",
      "squamous cell carcinoma of the vulva",
      "squamous cell carcinoma of vulva",
      "vulva epidermoid carcinoma",
      "vulva epidermoid cell carcinoma",
      "vulva squamous cell carcinoma",
      "vulvar epidermoid carcinoma",
      "vulvar epidermoid cell carcinoma",
      "vulvar squamous cell cancer",
      "vulvar squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4318,
      "label": "vulvar squamous neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        20293
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2072",
          "MEDGEN:276998",
          "NCIT:C40283",
          "UMLS:C1520097"
        ],
        "synonyms": [
          "mammalian vulva squamous cell neoplasm",
          "vulvar squamous neoplasm",
          "vulvar squamous tumor",
          "vulvar squamous tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vulva. Representative examples include vestibular papilloma, intraepithelial neoplasia, and squamous cell carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002195"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 6931,
      "label": "vulvar carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3735,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1294",
          "EFO:0002921",
          "GARD:0009349",
          "MEDGEN:146159",
          "NCIT:C4866",
          "Orphanet:494418",
          "SCTID:447882007",
          "UMLS:C0677055"
        ],
        "synonyms": [
          "cancer of the vulva",
          "cancer of vulva",
          "vulva cancer",
          "vulvar cancer",
          "carcinoma of mammalian vulva",
          "carcinoma of the vulva",
          "carcinoma of vulva",
          "mammalian vulva carcinoma",
          "vulva carcinoma",
          "vulvar carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the mammalian vulva"
      },
      "child_count": 18,
      "reference_id": "MONDO:0005215"
    }
  ],
  "children": [
    {
      "id": 4792,
      "label": "vulva verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7597,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3740",
          "GARD:0023236",
          "MEDGEN:234482",
          "NCIT:C6383",
          "UMLS:C1336983"
        ],
        "synonyms": [
          "mammalian vulva verrucous carcinoma",
          "verrucous carcinoma of the vulva",
          "verrucous carcinoma of vulva",
          "vulvar verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002758"
    },
    {
      "id": 5894,
      "label": "bartholin gland squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4848,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6961",
          "GARD:0023796",
          "MEDGEN:307249",
          "NCIT:C40293",
          "UMLS:C1511052"
        ],
        "synonyms": [
          "Bartholin's gland squamous cell carcinoma",
          "bartholin gland squamous cell carcinoma",
          "major vestibular gland squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant squamous epithelial cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004053"
    },
    {
      "id": 5925,
      "label": "vulvar basaloid squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7048",
          "GARD:0023814",
          "MEDGEN:384496",
          "NCIT:C40286",
          "UMLS:C2211850"
        ],
        "synonyms": [
          "vulvar basaloid carcinoma",
          "vulvar basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the vulva and is characterized by the presence of nests of malignant basaloid cells with a scant amount of cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004090"
    },
    {
      "id": 6021,
      "label": "vulvar keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6786,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7363",
          "GARD:0023872",
          "MEDGEN:378346",
          "NCIT:C40284",
          "UMLS:C2109334"
        ],
        "synonyms": [
          "vulvar keratinizing squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the vulva and is characterized by the presence of keratin pearls."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004199"
    },
    {
      "id": 6034,
      "label": "vulvar keratoacanthoma-like carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7408",
          "GARD:0023880",
          "NCIT:C40288"
        ],
        "synonyms": [
          "vulvar squamous cell carcinoma, keratoacanthoma type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rapidly growing squamous cell carcinoma that arises from the vulva. It is self-limited and is characterized by the presence of a central crater that contains squamous cells. The proliferating squamous cells infiltrate the dermis below and produce keratin masses that are pushed towards the surface of the tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004212"
    },
    {
      "id": 6035,
      "label": "vulvar non-keratinizing squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7409",
          "GARD:0023881",
          "MEDGEN:311488",
          "NCIT:C40285",
          "UMLS:C1520092"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the vulva and is characterized by the absence of keratin pearls."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004213"
    }
  ],
  "roots": [
    {
      "id": 4318,
      "label": "vulvar squamous neoplasm"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 6931,
      "label": "vulvar carcinoma"
    }
  ]
}