{
  "id": 21534,
  "label": "central nervous system infectious disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024619",
  "properties": {
    "xrefs": [
      "EFO:1001456",
      "GARD:0025438",
      "ICD9:349.89",
      "MEDGEN:1684837",
      "MESH:D002494",
      "NCIT:C27582",
      "SCTID:128117002",
      "UMLS:C4759823"
    ],
    "synonyms": [
      "central nervous system infectious disease",
      "central nervous system infectious disorder",
      "infectious disease of central nervous system",
      "central nervous system infection",
      "infections, central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4657,
      "label": "central nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:331",
          "EFO:0009386",
          "MEDGEN:892343",
          "MESH:D002493",
          "NCIT:C2934",
          "SCTID:23853001",
          "UMLS:C4021765"
        ],
        "synonyms": [
          "CNS disorder",
          "central nervous disease",
          "central nervous system disease",
          "central nervous system disease or disorder",
          "central nervous system disorder",
          "disease of central nervous system",
          "disease of the central nervous system",
          "disease or disorder of central nervous system",
          "disorder of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the central nervous system."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002602"
    },
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      "id": 19708,
      "label": "infectious disorder of the nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:349.89",
          "MEDGEN:108926",
          "NCIT:C27590",
          "Orphanet:98010",
          "SCTID:128116006",
          "UMLS:C0597039"
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        "synonyms": [
          "nervous system infectious disease",
          "nervous system infectious disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A infectious disease that involves the nervous system."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020010"
    }
  ],
  "children": [
    {
      "id": 3208,
      "label": "intracranial abscess",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6939,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10095",
          "ICD9:324.0",
          "MEDGEN:9529",
          "NCIT:C34734",
          "SCTID:27614006",
          "UMLS:C0021874",
          "icd11.foundation:1128677700"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An abscess that is located in the intracranial space."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000939"
    },
    {
      "id": 6561,
      "label": "infectious meningitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20347,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9471",
          "EFO:0000584",
          "GARD:0024106",
          "HP:0001287",
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          "ICD9:322",
          "MEDGEN:152668",
          "NCIT:C79598",
          "SCTID:312216007",
          "UMLS:C0729584"
        ],
        "synonyms": [
          "infectious meningitis",
          "infective meningitis",
          "meningitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004796"
    },
    {
      "id": 7097,
      "label": "prion disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:649",
          "EFO:0004720",
          "GARD:0024183",
          "ICD9:046.19",
          "MEDGEN:56445",
          "MESH:D017096",
          "NANDO:1200186",
          "NCIT:C128346",
          "SCTID:230284004",
          "UMLS:C0162534"
        ],
        "synonyms": [
          "spongiform encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal."
      },
      "child_count": 20,
      "reference_id": "MONDO:0005429"
    },
    {
      "id": 7264,
      "label": "cerebral malaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6860,
        7209,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14069",
          "EFO:0006857",
          "GARD:0024213",
          "ICD9:084.9",
          "MEDGEN:44258",
          "MESH:D016779",
          "NCIT:C128373",
          "SCTID:53622003",
          "UMLS:C0024534",
          "Wikipedia:Malaria"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A sequestration of Plasmodium falciparum in the brain, which can cause coma and/or seizures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005625"
    },
    {
      "id": 7327,
      "label": "central nervous system tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1638",
          "EFO:0007199",
          "GARD:0024220",
          "ICD9:013.2",
          "ICD9:013.20",
          "ICD9:013.35",
          "MEDGEN:82907",
          "Orphanet:641396",
          "SCTID:186217006",
          "UMLS:C0275904",
          "icd11.foundation:729372485"
        ],
        "synonyms": [
          "central nervous system tuberculosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with seizures, focal neurologic deficits, and intracranial hypertension. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as opportunistic infections, but also occur in immunocompetent individuals."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005696"
    },
    {
      "id": 7343,
      "label": "congenital toxoplasmosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4427,
        7581,
        17014,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13336",
          "EFO:0007220",
          "GARD:0018708",
          "ICD10CM:P37.1",
          "ICD9:771.2",
          "MEDGEN:52799",
          "MESH:D014125",
          "MedDRA:10010652",
          "NANDO:2200892",
          "NCIT:C50503",
          "Orphanet:858",
          "SCTID:73893000",
          "UMLS:C0040560",
          "icd11.foundation:1194018225"
        ],
        "synonyms": [
          "Toxoplasma embryofetopathy",
          "Toxoplasma embryopathy",
          "congenital toxoplasmosis",
          "mother-to-child transmission of toxoplasmosis",
          "toxoplasmosis, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Toxoplasma infection that is present from birth."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005715"
    },
    {
      "id": 7373,
      "label": "epidural abscess",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6939,
        7694,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11387",
          "EFO:0007260",
          "GARD:0024227",
          "MEDGEN:82848",
          "MESH:D020802",
          "SCTID:61974008",
          "UMLS:C0270629"
        ],
        "synonyms": [
          "extradural intraspinal abscess",
          "intraspinal epidural abscess",
          "intraspinal extradural abscess",
          "spinal epidural abscess",
          "spinal epidural abscess (disorder)",
          "spinal extradural abscess"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005752"
    },
    {
      "id": 7481,
      "label": "neuroschistosomiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16140,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13722",
          "EFO:0007394",
          "GARD:0024249",
          "MEDGEN:155718",
          "MESH:D020818",
          "UMLS:C0752191",
          "icd11.foundation:446216876"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Schistosomiasis of the brain, spinal cord, or meninges caused by infections with trematodes of the genus schistosoma (primarily schistosoma japonicum; schistosoma mansoni; and schistosoma haematobium in humans). S. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. S. mansoni and S. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (From Joynt, Clinical Neurology, 1998, Ch27, pp61-2)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005874"
    },
    {
      "id": 8409,
      "label": "subdural empyema",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6949,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11389",
          "EFO:1001196",
          "GARD:0024511",
          "MEDGEN:52531",
          "MESH:D013354",
          "MedDRA:10042360",
          "SCTID:37660004",
          "UMLS:C0038539"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An intracranial or rarely intraspinal suppurative process invading the space between the inner surface of the dura mater and the outer surface of the arachnoid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006984"
    },
    {
      "id": 18850,
      "label": "human prion disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018851",
          "Orphanet:56970"
        ],
        "synonyms": [
          "TSE",
          "transmissible spongiform encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Prion diseases are a group of rare transmissible disorders characterized by progressive debilitating neurological manifestations due to spongiform changes with an invariably fatal course. The disorders all involve accumulation of an abnormal prion protein in the central nervous system with no specific immunological response. Sporadic Creutzfeldt-Jakob disease (CJD) is the most frequent form accounting for about 85% of prion disease cases. The other forms of prion disease are genetic (5-15%) and include inherited CJD, fatal familial insomnia (FFI), and Familial Alzheimer-like prion disease. Acquired forms (< 5%) include iatrogenic CJD and variant CJD (vCDJ)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018926"
    },
    {
      "id": 19721,
      "label": "infectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025151",
          "ICD9:049.8",
          "ICD9:323.4",
          "MEDGEN:108917",
          "MESH:D000069544",
          "NCIT:C79550",
          "SCTID:312215006",
          "UMLS:C0596773"
        ],
        "synonyms": [
          "encephalitis infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020067"
    },
    {
      "id": 21351,
      "label": "viral infection of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025391",
          "ICD10CM:A80-A89",
          "ICD10WHO:A80-A89",
          "MEDGEN:91141",
          "MESH:D020805",
          "SCTID:302810003",
          "UMLS:C0348165"
        ],
        "synonyms": [
          "viral infection of central nervous system",
          "central nervous system viral infection",
          "viral disease of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 14,
      "reference_id": "MONDO:0024318"
    }
  ],
  "roots": [
    {
      "id": 4657,
      "label": "central nervous system disorder"
    },
    {
      "id": 19708,
      "label": "infectious disorder of the nervous system"
    }
  ]
}