{
  "id": 21537,
  "label": "thyroid gland adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024622",
  "properties": {
    "xrefs": [
      "DOID:0080524",
      "GARD:0025440",
      "MEDGEN:309935",
      "NCIT:C27380",
      "UMLS:C1704228"
    ],
    "synonyms": [
      "thyroid adenocarcinoma",
      "thyroid gland adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 16049,
      "label": "thyroid gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4245,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3963",
          "EFO:0002892",
          "GARD:0019763",
          "HP:0002890",
          "MEDGEN:107811",
          "MedDRA:10007476",
          "NANDO:2200074",
          "NCIT:C4815",
          "Orphanet:100088",
          "SCTID:448216007",
          "UMLS:C0549473"
        ],
        "synonyms": [
          "cancer of the thyroid",
          "cancer of thyroid",
          "head and neck cancer, thyroid",
          "thyroid cancer",
          "thyroid gland cancer",
          "carcinoma of the thyroid",
          "carcinoma of the thyroid gland",
          "carcinoma of thyroid",
          "carcinoma of thyroid gland",
          "thyroid carcinoma",
          "thyroid gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic."
      },
      "child_count": 22,
      "reference_id": "MONDO:0015075"
    }
  ],
  "children": [
    {
      "id": 6768,
      "label": "thyroid gland follicular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16290,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3962",
          "EFO:0000501",
          "GARD:0024144",
          "HP:0006731",
          "ICDO:8330/3",
          "ICDO:8331/3",
          "MEDGEN:64630",
          "MESH:D018263",
          "NCIT:C8054",
          "ONCOTREE:THFO",
          "SCTID:255028004",
          "UMLS:C0206682"
        ],
        "synonyms": [
          "follicular cancer of the thyroid",
          "follicular cancer of the thyroid gland",
          "follicular cancer of thyroid",
          "follicular cancer of thyroid gland",
          "thyroid gland follicular cancer",
          "well-differentiated follicular carcinoma",
          "carcinoma of thyroid follicle",
          "carcinoma, follicular cell, malignant",
          "follicular carcinoma",
          "follicular carcinoma of the thyroid",
          "follicular carcinoma of the thyroid gland",
          "follicular carcinoma of thyroid",
          "follicular carcinoma of thyroid gland",
          "follicular thyroid cancer",
          "follicular thyroid carcinoma",
          "follicular thyroid gland carcinoma",
          "thyroid follicle carcinoma",
          "thyroid follicular carcinoma",
          "thyroid gland follicular carcinoma",
          "well-differentiated follicular adenocarcinoma",
          "follicular adenocarcinoma",
          "follicular adenocarcinoma (morphologic abnormality)",
          "follicular adenocarcinoma, well differentiated",
          "follicular adenocarcinoma, well differentiated (morphologic abnormality)",
          "thyroid gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The nuclear features which characterize the thyroid gland papillary carcinoma are absent. Radiation exposure is a risk factor and it comprises approximately 10% to 15% of thyroid cancers. Clinically, it usually presents as a solitary mass in the thyroid gland. It is generally unifocal and thickly encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures include thyroid ultrasound and fine needle biopsy."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005034"
    },
    {
      "id": 6803,
      "label": "thyroid gland papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        16290,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3969",
          "EFO:0000641",
          "GARD:0024148",
          "HP:0002895",
          "MEDGEN:66773",
          "NCIT:C4035",
          "ONCOTREE:THPA",
          "SCTID:255029007",
          "UMLS:C0238463"
        ],
        "synonyms": [
          "papillary cancer of the thyroid",
          "papillary cancer of the thyroid gland",
          "papillary cancer of thyroid",
          "papillary cancer of thyroid gland",
          "papillary carcinoma of the thyroid",
          "papillary carcinoma of the thyroid gland",
          "papillary carcinoma of thyroid",
          "papillary carcinoma of thyroid gland",
          "papillary thyroid cancer",
          "papillary thyroid carcinoma",
          "papillary thyroid gland carcinoma",
          "thyroid gland papillary cancer",
          "thyroid gland papillary carcinoma",
          "thyroid papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005075"
    },
    {
      "id": 7964,
      "label": "thyroid gland mucoepidermoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5029,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4687",
          "EFO:1000590",
          "GARD:0024420",
          "MEDGEN:270845",
          "NCIT:C38762",
          "UMLS:C1513721"
        ],
        "synonyms": [
          "mucoepidermoid thyroid carcinoma",
          "mucoepidermoid thyroid gland carcinoma",
          "thyroid gland mucoepidermoid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary, low grade carcinoma of the thyroid gland composed of groups of squamoid and mucous cells, surrounded by fibrous tissue. Prominent cystic structures may be present. The clinical course is usually indolent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006463"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 16049,
      "label": "thyroid gland carcinoma"
    }
  ]
}