{
  "id": 21540,
  "label": "defective phagocytic cell engulfment",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024626",
  "properties": {
    "xrefs": [
      "MEDGEN:585050",
      "SCTID:234585008",
      "UMLS:C0398742"
    ],
    "synonyms": [
      "defective phagocytic cell killing"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 21541,
      "label": "phagocytic cell dysfunction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:585044",
          "SCTID:302874002",
          "UMLS:C0398732"
        ],
        "synonyms": [
          "defective phagocytosis",
          "phagocytic cell dysfunction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0024627"
    }
  ],
  "children": [
    {
      "id": 10731,
      "label": "specific granule deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16630,
        21540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010778",
          "MEDGEN:140766",
          "MESH:C562873",
          "OMIMPS:245480",
          "Orphanet:169142",
          "SCTID:234587000",
          "UMLS:C0398593"
        ],
        "synonyms": [
          "neutrophil-specific granule deficiency",
          "recurrent infection due to specific granule deficiency",
          "specific granule deficiency",
          "SGD",
          "lactoferrin-deficient neutrophils",
          "neutrophil lactoferrin deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0009506"
    },
    {
      "id": 10908,
      "label": "myeloperoxidase deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        16630,
        21540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003868",
          "ICD9:288.8",
          "MEDGEN:96015",
          "MESH:C562864",
          "NANDO:1200358",
          "NANDO:2200758",
          "OMIM:254600",
          "Orphanet:2587",
          "SCTID:234433009",
          "UMLS:C0398595",
          "icd11.foundation:1933575033"
        ],
        "synonyms": [
          "MPO deficiency",
          "myeloperoxidase deficiency",
          "MPOD"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0009694"
    },
    {
      "id": 14627,
      "label": "gluthathione peroxidase deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18954,
        21540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024936",
          "MEDGEN:473098",
          "OMIM:614164",
          "SCTID:234590006",
          "UMLS:C0398747"
        ],
        "synonyms": [
          "gluthathione peroxidase deficiency",
          "hemolytic anaemia due to glutathione peroxidase deficiency",
          "hemolytic anemia due to glutathione peroxidase deficiency",
          "GPXD",
          "glutathione peroxidase deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013601"
    },
    {
      "id": 18115,
      "label": "inherited glutathione synthetase deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21540,
        22996
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080699",
          "GARD:0010047",
          "MEDGEN:1876682",
          "MESH:C536835",
          "NCIT:C128193",
          "Orphanet:32",
          "SCTID:234589002",
          "UMLS:C5979912"
        ],
        "synonyms": [
          "5-oxoprolinuria",
          "GSSD",
          "glutathione synthetase deficiency",
          "inborn error of glutathione synthase activity",
          "inborn glutathione synthase activity disorder",
          "inherited glutathione synthetase deficiency",
          "pyroglutamic aciduria",
          "pyroglutamicaciduria",
          "rare inborn error of glutathione synthase activity",
          "oxoprolinase deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Glutathione synthetase deficiency is characterized by hemolytic anemia, associated with metabolic acidosis and 5-oxoprolinuria in moderate forms, and with progressive neurological symptoms and recurrent bacterial infections in the most severe forms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0017909"
    },
    {
      "id": 18402,
      "label": "chronic granulomatous disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7512,
        20399,
        21540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3265",
          "GARD:0006100",
          "MEDGEN:5377",
          "MESH:D006105",
          "MedDRA:10008906",
          "NANDO:1200357",
          "NANDO:2200757",
          "NCIT:C26788",
          "NORD:968",
          "OMIMPS:306400",
          "Orphanet:379",
          "SCTID:387759001",
          "UMLS:C0018203",
          "icd11.foundation:1329764681"
        ],
        "synonyms": [
          "CGD",
          "chronic septic granulomatosis",
          "granulomatous disease, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Chronic granulomatous disease (CGD) is a rare primary immunodeficiency, mainly affecting phagocytes, which is characterized by an increased susceptibility to severe and recurrent bacterial and fungal infections, along with the development of granulomas."
      },
      "child_count": 28,
      "reference_id": "MONDO:0018305"
    }
  ],
  "roots": [
    {
      "id": 21541,
      "label": "phagocytic cell dysfunction"
    }
  ]
}