{
  "id": 21545,
  "label": "large intestine disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024634",
  "properties": {
    "xrefs": [
      "MEDGEN:574315",
      "SCTID:119523007",
      "UMLS:C0341321"
    ],
    "synonyms": [
      "disease of large intestine",
      "disease or disorder of large intestine",
      "disorder of large intestine",
      "large intestine disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A disease that involves the large intestine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6756,
      "label": "intestinal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5295",
          "EFO:0009431",
          "ICD9:520-579",
          "ICD9:560-569",
          "ICD9:564",
          "ICD9:564.4",
          "ICD9:569",
          "ICD9:569.4",
          "ICD9:569.49",
          "ICD9:569.89",
          "ICD9:569.9",
          "ICD9:570-579",
          "ICD9:575",
          "MEDGEN:7130",
          "MESH:D007410",
          "NCIT:C26801",
          "SCTID:85919009",
          "UMLS:C0021831"
        ],
        "synonyms": [
          "disease of intestine",
          "disease or disorder of intestine",
          "disorder of intestine",
          "intestinal disease",
          "intestinal disorder",
          "intestine disease",
          "intestine disease or disorder",
          "disease, intestinal",
          "diseases, intestinal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the small or large intestine."
      },
      "child_count": 58,
      "reference_id": "MONDO:0005020"
    }
  ],
  "children": [
    {
      "id": 2895,
      "label": "anal canal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7430,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050688",
          "ICD10CM:C21.1",
          "ICD9:154.2",
          "MEDGEN:509296",
          "SCTID:363352004",
          "UMLS:C0153445",
          "icd11.foundation:655574575"
        ],
        "synonyms": [
          "anal canal cancer",
          "cancer of anal canal",
          "malignant anal canal neoplasm",
          "malignant neoplasm of anal canal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the anal canal"
      },
      "child_count": 2,
      "reference_id": "MONDO:0000405"
    },
    {
      "id": 3792,
      "label": "rectal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1285",
          "EFO:0009685",
          "ICD9:569.49",
          "MEDGEN:19701",
          "MESH:D012002",
          "SCTID:5964004",
          "UMLS:C0034882"
        ],
        "synonyms": [
          "disease of rectum",
          "disease or disorder of rectum",
          "disorder of rectum",
          "rectal disorder",
          "rectum disease",
          "rectum disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease that involves the rectum."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001593"
    },
    {
      "id": 5340,
      "label": "colonic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5353",
          "MEDGEN:1049",
          "MESH:D003108",
          "SCTID:128524007",
          "UMLS:C0009373"
        ],
        "synonyms": [
          "colon disease",
          "colon disease or disorder",
          "disease of colon",
          "disease or disorder of colon",
          "disorder of colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Pathological processes in the colon region of the large intestine (intestine, large)."
      },
      "child_count": 13,
      "reference_id": "MONDO:0003409"
    },
    {
      "id": 7022,
      "label": "colorectal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20357,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004142",
          "MEDGEN:3171",
          "MESH:D015179",
          "NCIT:C2956",
          "UMLS:C0009404"
        ],
        "synonyms": [
          "colorectal neoplasm",
          "colorectal tumor",
          "colorectal tumour",
          "colorectum neoplasm",
          "colorectum neoplasm (disease)",
          "colorectum tumor",
          "colorectum tumour",
          "large bowel neoplasm",
          "large bowel tumor",
          "large bowel tumour",
          "large intestinal neoplasm",
          "large intestine neoplasm",
          "large intestine tumor",
          "large intestine tumour",
          "neoplasm of colorectum",
          "neoplasm of large bowel",
          "neoplasm of the large bowel",
          "tumor of colorectum",
          "tumor of large bowel",
          "tumor of the large bowel",
          "tumour of colorectum",
          "tumour of large bowel",
          "tumour of the large bowel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005335"
    },
    {
      "id": 7185,
      "label": "Crohn's colitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6749,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060192",
          "EFO:0005622",
          "MEDGEN:57618",
          "NANDO:1200446",
          "NCIT:C35211",
          "UMLS:C0156147"
        ],
        "synonyms": [
          "Crohn colitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Crohn's disease affecting the colon."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005532"
    },
    {
      "id": 18546,
      "label": "epithelial tumor of anal canal",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        20357,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021771",
          "MEDGEN:1842505",
          "Orphanet:424010",
          "UMLS:C5681209"
        ],
        "synonyms": [
          "anal canal epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A epithelial neoplasm that involves the anal canal."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018516"
    },
    {
      "id": 19183,
      "label": "shigellosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2837,
        3725,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12385",
          "EFO:0005585",
          "GARD:0004818",
          "ICD10CM:A03",
          "ICD10WHO:A03",
          "ICD9:004",
          "ICD9:004.0",
          "ICD9:004.1",
          "ICD9:004.2",
          "ICD9:004.3",
          "ICD9:004.9",
          "MEDGEN:8513",
          "MESH:D004405",
          "MedDRA:10017915",
          "MedDRA:10054178",
          "NCIT:C157978",
          "Orphanet:810",
          "SCTID:36188001",
          "UMLS:C0013371",
          "icd11.foundation:2080365623"
        ],
        "synonyms": [
          "shigellosis",
          "Shigella boydii infectious disease",
          "Shigella flexneri infectious disease",
          "Shigella sonnei infectious disease",
          "Shigella dysentery",
          "flexner's dysentery",
          "japanese dysentery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Shigellosis is a bacterial infection leading to dysentery and is caused by Shigella, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: S. dysenteriae, S. flexneri, S. boydii and S. sonnei, all of which cause bacillary dysentery and are strictly limited to human hosts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019345"
    },
    {
      "id": 20546,
      "label": "polyp of large intestine",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6807,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:182694",
          "NCIT:C5679",
          "SCTID:399505005",
          "UMLS:C0949059",
          "icd11.foundation:537826614"
        ],
        "synonyms": [
          "colorectal polyp",
          "large bowel polyp",
          "large intestine polyp",
          "polyp of large bowel",
          "polyp of the large bowel",
          "polyp of the large intestine"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A polyp that involves the large intestine."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021392"
    },
    {
      "id": 20567,
      "label": "benign neoplasm of large intestine",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5052,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:91125",
          "NCIT:C4610",
          "SCTID:92170008",
          "UMLS:C0347272",
          "icd11.foundation:477388501"
        ],
        "synonyms": [
          "benign colorectal neoplasm",
          "benign colorectal neoplasms",
          "benign colorectal tumor",
          "benign colorectal tumors",
          "benign colorectal tumour",
          "benign colorectal tumours",
          "benign large bowel neoplasm",
          "benign large bowel tumor",
          "benign large bowel tumour",
          "benign large intestine neoplasm",
          "benign large intestine tumor",
          "benign large intestine tumour",
          "benign neoplasm of large bowel",
          "benign neoplasm of the large bowel",
          "benign neoplasm of the large intestine",
          "benign tumor of large bowel",
          "benign tumor of large intestine",
          "benign tumor of the large bowel",
          "benign tumor of the large intestine",
          "benign tumour of large bowel",
          "benign tumour of large intestine",
          "benign tumour of the large bowel",
          "benign tumour of the large intestine",
          "colorectal neoplasms, benign",
          "colorectal tumors, benign",
          "large intestine benign neoplasm",
          "neoplasms, colorectal, benign",
          "tumors, colorectal, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the large intestine."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021444"
    },
    {
      "id": 21566,
      "label": "colorectal Kaposi sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6785,
        7430,
        21545,
        23208
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025451",
          "MEDGEN:474466",
          "NCIT:C96510",
          "UMLS:C3272833"
        ],
        "synonyms": [
          "Kaposi's sarcoma (disease) of large intestine",
          "colorectal Kaposi sarcoma",
          "large intestinal Kaposi sarcoma",
          "large intestine Kaposi's sarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A Kaposi sarcoma that arises from the colon or rectum."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024659"
    },
    {
      "id": 23661,
      "label": "disorder of appendix",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:60000",
          "EFO:0009542",
          "ICD10CM:K35-K38",
          "ICD9:543.9",
          "MEDGEN:540821",
          "SCTID:18526009",
          "UMLS:C0267613"
        ],
        "synonyms": [
          "appendiceal disease",
          "disease of appendix",
          "disease of vermiform appendix",
          "disease or disorder of vermiform appendix",
          "disorder of appendix",
          "disorder of vermiform appendix",
          "vermiform appendix disease",
          "vermiform appendix disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the vermiform appendix."
      },
      "child_count": 3,
      "reference_id": "MONDO:0056798"
    }
  ],
  "roots": [
    {
      "id": 6756,
      "label": "intestinal disorder"
    }
  ]
}