{
  "id": 21546,
  "label": "small intestine disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024635",
  "properties": {
    "xrefs": [
      "MEDGEN:574283",
      "SCTID:119522002",
      "UMLS:C0341268"
    ],
    "synonyms": [
      "disease of small intestine",
      "disease or disorder of small intestine",
      "disorder of small intestine",
      "small intestine disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A disease that involves the small intestine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6756,
      "label": "intestinal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5295",
          "EFO:0009431",
          "ICD9:520-579",
          "ICD9:560-569",
          "ICD9:564",
          "ICD9:564.4",
          "ICD9:569",
          "ICD9:569.4",
          "ICD9:569.49",
          "ICD9:569.89",
          "ICD9:569.9",
          "ICD9:570-579",
          "ICD9:575",
          "MEDGEN:7130",
          "MESH:D007410",
          "NCIT:C26801",
          "SCTID:85919009",
          "UMLS:C0021831"
        ],
        "synonyms": [
          "disease of intestine",
          "disease or disorder of intestine",
          "disorder of intestine",
          "intestinal disease",
          "intestinal disorder",
          "intestine disease",
          "intestine disease or disorder",
          "disease, intestinal",
          "diseases, intestinal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the small or large intestine."
      },
      "child_count": 58,
      "reference_id": "MONDO:0005020"
    }
  ],
  "children": [
    {
      "id": 3469,
      "label": "small intestine diverticulitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6056,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11223",
          "ICD9:562.01",
          "ICD9:562.02",
          "MEDGEN:540732",
          "SCTID:56165008",
          "UMLS:C0267502",
          "icd11.foundation:1351188281"
        ],
        "synonyms": [
          "diverticulitis of small intestine",
          "diverticulosis of small intestine with haemorrhage",
          "small intestine diverticulitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A diverticulitis that involves the small intestine."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001229"
    },
    {
      "id": 4880,
      "label": "duodenal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4072",
          "ICD9:537.89",
          "ICD9:537.9",
          "MEDGEN:8502",
          "MESH:D004378",
          "SCTID:52182008",
          "UMLS:C0013289",
          "icd11.foundation:1195691020"
        ],
        "synonyms": [
          "disease of duodenum",
          "disease or disorder of duodenum",
          "disorder of duodenum",
          "duodenum disease",
          "duodenum disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Pathological conditions in the duodenum region of the small intestine (intestine, small)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002866"
    },
    {
      "id": 6071,
      "label": "small intestine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20357,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7505",
          "MEDGEN:91055",
          "NCIT:C4432",
          "SCTID:126832004",
          "UMLS:C0345832"
        ],
        "synonyms": [
          "neoplasm of small bowel",
          "neoplasm of small intestine",
          "neoplasm of the small bowel",
          "neoplasm of the small intestine",
          "small bowel neoplasm",
          "small bowel tumor",
          "small bowel tumour",
          "small intestinal neoplasm",
          "small intestine neoplasm",
          "small intestine neoplasm (disease)",
          "small intestine tumor",
          "small intestine tumour",
          "tumor of small bowel",
          "tumor of small intestine",
          "tumor of the small bowel",
          "tumor of the small intestine",
          "tumour of small bowel",
          "tumour of small intestine",
          "tumour of the small bowel",
          "tumour of the small intestine"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the small intestine. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0004251"
    },
    {
      "id": 6854,
      "label": "celiac disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        5714,
        20033,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10608",
          "EFO:0001060",
          "ICD10CM:K90.0",
          "ICD9:579.0",
          "MEDGEN:3291",
          "MESH:D002446",
          "NCIT:C26714",
          "OMIMPS:212750",
          "Orphanet:555",
          "SCTID:396331005",
          "UMLS:C0007570",
          "icd11.foundation:2005943638"
        ],
        "synonyms": [
          "celiac disease",
          "celiac sprue",
          "coeliac sprue",
          "gluten intolerance",
          "gluten-induced enteropathy",
          "non tropical sprue"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005130"
    },
    {
      "id": 7004,
      "label": "pouchitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003921",
          "GARD:0020510",
          "ICD10CM:K91.850",
          "ICD9:569.71",
          "MEDGEN:138232",
          "MESH:D019449",
          "Orphanet:217067",
          "UMLS:C0376620"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Acute inflammation in the intestinal mucosa of the continent ileal reservoir (or pouch) in patients who have undergone ileostomy and restorative proctocolectomy (proctocolectomy, restorative)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005312"
    },
    {
      "id": 10702,
      "label": "atresia of small intestine",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20383,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000140",
          "MEDGEN:78590",
          "MESH:C538260",
          "MedDRA:10010626",
          "NCIT:C98828",
          "NORD:1309",
          "OMIM:243600",
          "Orphanet:1201",
          "UMLS:C0266172",
          "icd11.foundation:1949256262"
        ],
        "synonyms": [
          "Jejunal Atresia",
          "Jejunoileal atresia",
          "apple peel syndrome",
          "atresia of the small intestine",
          "congenital small intestine atresia",
          "intestinal atresia type IIIb",
          "jejunal atresia",
          "small intestinal atresia",
          "small intestine atresia",
          "APSB",
          "apple peel small bowel syndrome",
          "apple-peel intestinal atresia",
          "congenital atresia of the small intestine",
          "familial apple peel jejunal atresia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Atresia of small intestine is a special form of intestinal atresia with absence of mesentery, which is most likely due to an intrauterine intestinal vascular accident. Newborns are usually preterm infants with low birth-weights, that encounter feeding difficulties (including vomiting with initial feeds, which may later worsened and the abdomen becomes progressively distended) as well as failure to thrive. Affected children present disrupted bowel loops assuming a spiral configuration resembling an 'apple peel' and may have less than half of the normal length of the small bowel and a physiologically short bowel. Atresia of small intestine is characterized by jejunal atresia near the ligament of Treitz, foreshortened bowel, and a large mesenteric gap. The bowel distal to the atresia is precariously supplied. Atresia of small intestine may be a manifestation of cystic fibrosis. The most important cause of mortality is short bowel syndrome, encountered in 65% of cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009476"
    },
    {
      "id": 15106,
      "label": "congenital short bowel syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20383,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016592",
          "MEDGEN:1784105",
          "Orphanet:2301",
          "SCTID:715201005",
          "UMLS:C5441717",
          "icd11.foundation:1672462112"
        ],
        "synonyms": [
          "CSBS",
          "congenital short bowel syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Congenital short bowel syndrome is a rare intestinal disorder of neonates of unknown etiology. Patients are born with a short small bowel (less than 75 cm in length) that compromises proper intestinal absorption and leads chronic diarrhea, vomiting and failure to thrive."
      },
      "child_count": 4,
      "reference_id": "MONDO:0014097"
    },
    {
      "id": 23231,
      "label": "enteritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4384,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:4964",
          "MESH:D004751",
          "NCIT:C26765",
          "SCTID:64613007",
          "UMLS:C0014335"
        ],
        "synonyms": [
          "enteritis",
          "enteritis of small intestine",
          "inflammation of small intestine",
          "small intestine inflammation",
          "Enteritides",
          "enteritis, inflammatory disorder of small intestine"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Inflammation of the small intestine."
      },
      "child_count": 6,
      "reference_id": "MONDO:0043579"
    },
    {
      "id": 24369,
      "label": "small intestinal bacterial overgrowth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21546,
        23208
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1708316",
          "UMLS:C3160854"
        ],
        "synonyms": [
          "SIBO"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The presence of excessive bacteria in the small intestine that can result from result from failure of the gastric acid barrier, failure of small intestinal motility, anatomic alterations, or impairment of systemic and local immunity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0400000"
    },
    {
      "id": 26038,
      "label": "small intestine duplication",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027401",
          "MEDGEN:576852",
          "Orphanet:662456",
          "UMLS:C0345268"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0971086"
    }
  ],
  "roots": [
    {
      "id": 6756,
      "label": "intestinal disorder"
    }
  ]
}