{
  "id": 21580,
  "label": "tenosynovial giant cell tumor, diffuse type",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024686",
  "properties": {
    "xrefs": [
      "DOID:2702",
      "DOID:9898",
      "GARD:0007396",
      "ICD10CM:M12.2",
      "ICD9:719.2",
      "ICD9:719.20",
      "ICD9:719.28",
      "ICDO:9251/0",
      "MEDGEN:11691",
      "MESH:D013586",
      "NCIT:C3401",
      "NORD:1916",
      "ONCOTREE:TGCT",
      "Orphanet:66627",
      "SCTID:95412009",
      "UMLS:C0039106"
    ],
    "synonyms": [
      "TGCT",
      "TSGCT",
      "Tenosynovial Giant Cell Tumor",
      "diffuse giant cell neoplasm of Tenosynovium",
      "diffuse giant cell neoplasm of tendon sheath",
      "diffuse giant cell neoplasm of the Tenosynovium",
      "diffuse giant cell tumor of Tenosynovium",
      "diffuse giant cell tumor of tendon sheath",
      "diffuse giant cell tumor of the Tenosynovium",
      "diffuse giant cell tumour of Tenosynovium",
      "diffuse giant cell tumour of tendon sheath",
      "diffuse giant cell tumour of the Tenosynovium",
      "diffuse tenosynovial giant cell neoplasm",
      "diffuse tenosynovial giant cell tumor",
      "diffuse tenosynovial giant cell tumour",
      "pigmented villonodular synovitis",
      "tenosynovial giant cell tumor, diffuse type",
      "diffuse pigmented villonodular synovitis",
      "diffuse-type GCT",
      "diffuse-type giant cell tumor",
      "diffuse-type giant cell tumour",
      "localised pigmented villonodular synovitis",
      "localized pigmented villonodular synovitis",
      "tenosynovial giant cell tumor",
      "tenosynovial giant cell tumor diffuse type",
      "tenosynovial giant cell tumors",
      "tenosynovial giant cell tumour",
      "tenosynovial giant cell tumour diffuse type",
      "tenosynovial giant cell tumours",
      "villonodular synovitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4592,
      "label": "tenosynovial giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4297,
        4597,
        20678,
        21600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:314",
          "EFO:1000562",
          "ICD9:727.89",
          "ICDO:9252/0",
          "MEDGEN:232927",
          "NCIT:C3402",
          "SCTID:310605004",
          "UMLS:C1318543"
        ],
        "synonyms": [
          "fibrous histiocytoma of tendon sheath",
          "giant cell neoplasm of Tenosynovium",
          "giant cell neoplasm of tendon sheath",
          "giant cell neoplasm of the Tenosynovium",
          "giant cell tumor of Tenosynovium",
          "giant cell tumor of tendon sheath",
          "giant cell tumor of the Tenosynovium",
          "giant cell tumour of the Tenosynovium",
          "tendon sheath giant cell neoplasm",
          "tendon sheath giant cell tumor",
          "tendon sheath giant cell tumour",
          "tenosynovial giant cell neoplasm",
          "tenosynovial giant cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002522"
    },
    {
      "id": 21582,
      "label": "benign synovial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4597,
        23337
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:9040/0",
          "MEDGEN:113161",
          "NCIT:C3829",
          "UMLS:C0221289"
        ],
        "synonyms": [
          "benign neoplasm of synovium",
          "benign neoplasm of the synovium",
          "benign synovial neoplasm",
          "benign synovial tumor",
          "benign synovial tumour",
          "benign synovioma",
          "benign synovium neoplasm",
          "benign tumor of synovium",
          "benign tumor of the synovium",
          "benign tumour of synovium",
          "benign tumour of the synovium",
          "synovioma, benign",
          "synovium neoplasm, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign neoplasm arising from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath and localized giant cell tumor of tendon sheath."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024715"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4592,
      "label": "tenosynovial giant cell tumor"
    },
    {
      "id": 21582,
      "label": "benign synovial neoplasm"
    }
  ]
}