{
  "id": 21602,
  "label": "secondary carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024878",
  "properties": {
    "xrefs": [
      "MEDGEN:88450",
      "NCIT:C36310",
      "UMLS:C0085668"
    ],
    "synonyms": [
      "secondary carcinoma"
    ],
    "definition": "A carcinoma that arises from a pre-existing lower grade epithelial lesion, or as a result of a primary carcinoma that has spread to secondary sites, or due to a complication of a cancer treatment."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 21605,
      "label": "secondary malignant neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        21606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009812",
          "ICD9:198.89",
          "ICD9:199.1",
          "MEDGEN:473807",
          "NCIT:C4968",
          "SCTID:128462008",
          "UMLS:C3266877"
        ],
        "synonyms": [
          "secondary cancer",
          "secondary malignancy",
          "secondary malignant neoplasm"
        ],
        "definition": "A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024881"
    }
  ],
  "children": [
    {
      "id": 21603,
      "label": "metastatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21602,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/6",
          "MEDGEN:235141",
          "NCIT:C3482",
          "UMLS:C1384494",
          "icd11.foundation:553023050"
        ],
        "synonyms": [
          "metastatic carcinoma"
        ],
        "definition": "A carcinoma which has spread from the original site of growth to another anatomic site."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024879"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 21605,
      "label": "secondary malignant neoplasm"
    }
  ]
}