{
  "id": 21604,
  "label": "metastatic malignant neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024880",
  "properties": {
    "xrefs": [
      "MEDGEN:422475",
      "NCIT:C36263",
      "UMLS:C2939419",
      "icd11.foundation:1399468320"
    ],
    "synonyms": [
      "malignant metastatic neoplasm",
      "metastatic cancer",
      "metastatic malignant neoplasm",
      "metastatic neoplasm, malignant"
    ],
    "definition": "A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 21605,
      "label": "secondary malignant neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        21606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009812",
          "ICD9:198.89",
          "ICD9:199.1",
          "MEDGEN:473807",
          "NCIT:C4968",
          "SCTID:128462008",
          "UMLS:C3266877"
        ],
        "synonyms": [
          "secondary cancer",
          "secondary malignancy",
          "secondary malignant neoplasm"
        ],
        "definition": "A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024881"
    },
    {
      "id": 21607,
      "label": "metastatic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009709",
          "ICDO:8000/6",
          "MEDGEN:422476",
          "NCIT:C3261",
          "UMLS:C2939420"
        ],
        "synonyms": [
          "metastatic disease",
          "metastatic neoplasm",
          "metastatic tumor",
          "metastatic tumour"
        ],
        "definition": "A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology."
      },
      "child_count": 1,
      "reference_id": "MONDO:0024883"
    }
  ],
  "children": [
    {
      "id": 21603,
      "label": "metastatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21602,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/6",
          "MEDGEN:235141",
          "NCIT:C3482",
          "UMLS:C1384494",
          "icd11.foundation:553023050"
        ],
        "synonyms": [
          "metastatic carcinoma"
        ],
        "definition": "A carcinoma which has spread from the original site of growth to another anatomic site."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024879"
    },
    {
      "id": 23035,
      "label": "metastatic malignant neoplasm in the colon",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:83432",
          "NCIT:C8411",
          "UMLS:C0346974"
        ],
        "synonyms": [
          "metastatic malignant neoplasm in the colon",
          "metastatic malignant neoplasm to the colon",
          "metastatic neoplasm to the colon",
          "metastatic tumor to the colon",
          "metastatic tumour to the colon"
        ],
        "definition": "The spread of a malignant neoplasm to the colon. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0041447"
    },
    {
      "id": 23036,
      "label": "metastasis from malignant tumor of colon",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20304,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:705366",
          "SCTID:314998002",
          "UMLS:C1282500"
        ],
        "synonyms": [
          "metastasis from malignant tumor of colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0041448"
    },
    {
      "id": 23475,
      "label": "metastatic malignant neoplasm in the spinal cord",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5449,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027980",
          "MEDGEN:138075",
          "NCIT:C4585",
          "SCTID:94600009",
          "UMLS:C0347016"
        ],
        "synonyms": [
          "Metastatic malignant neoplasm in the spinal cord",
          "Metastatic malignant neoplasm to the spinal cord",
          "Metastatic neoplasm to the spinal cord",
          "Metastatic tumor to the spinal cord",
          "Metastatic tumour to the spinal cord",
          "Secondary malignant neoplasm to the spinal cord",
          "Secondary malignant tumor to the spinal cord",
          "Secondary malignant tumour to the spinal cord",
          "metastasis to spinal cord"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm that has spread to the spinal cord from another anatomic site or system. Representative examples include carcinoma, lymphoma, and melanoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044912"
    },
    {
      "id": 23476,
      "label": "metastatic malignant neoplasm in the eye",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4353,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:91115",
          "NCIT:C4586",
          "SCTID:94292003",
          "UMLS:C0347019"
        ],
        "synonyms": [
          "Metastases to eye",
          "Metastases to the eye",
          "Metastatic malignant neoplasm in the eye",
          "Metastatic malignant neoplasm to the eye",
          "Metastatic neoplasm to the eye",
          "Metastatic tumor to the eye",
          "Metastatic tumour to the eye",
          "eye metastasis",
          "metastasis to eye",
          "metastasis to the eye"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant neoplasm that has spread to the eye from another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044913"
    },
    {
      "id": 24614,
      "label": "neoplastic meningitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:352817",
          "NCIT:C27383",
          "NCIT:C3814",
          "UMLS:C1704231",
          "icd11.foundation:262966673"
        ],
        "synonyms": [
          "carcinomatous meningitis",
          "leptomeningeal carcinoma",
          "leptomeningeal carcinomatosis",
          "leptomeningeal metastasis",
          "meningeal carcinomatosis",
          "meningeal metastasis",
          "metastatic malignant neoplasm in the leptomeninges"
        ],
        "definition": "Metastatic neoplasm in which the tumor cells spread to leptomeninges (pia and arachnoid) and subarachnoid space. The most common primary tumors metastasizing to the leptomeninges are breast and lung carcinomas, melanoma, aggressive non-Hodgkin lymphoma, and acute lymphocytic leukemia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700219"
    },
    {
      "id": 29256,
      "label": "metastatic malignant neoplasm in the brain",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3853,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028142",
          "MEDGEN:113095",
          "UMLS:C0220650"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm that has spread to the brain from another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:1040026"
    }
  ],
  "roots": [
    {
      "id": 21605,
      "label": "secondary malignant neoplasm"
    },
    {
      "id": 21607,
      "label": "metastatic neoplasm"
    }
  ]
}