{ "id": 21613, "label": "pineal parenchymal cell neoplasm", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0024890", "properties": { "xrefs": [ "ICDO:9360/1", "NCIT:C6965" ], "synonyms": [ "neoplasm of pineal gland", "neoplasm of the pineal gland", "pineal gland neoplasm", "pineal gland tumor", "pineal gland tumour", "pineal parenchymal cell neoplasm", "pineal parenchymal cell tumor", "pineal parenchymal cell tumour", "pineal parenchymal neoplasm", "pineal parenchymal tumor", "pineal parenchymal tumour", "pineocytic neoplasm", "pineocytic tumor", "pineocytic tumour", "tumor of pineal gland", "tumor of the pineal gland", "tumour of pineal gland", "tumour of the pineal gland" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A neoplasm arising from the pineocyte, a cell with photosensory and neuroendocrine functions. It may be composed of mature elements or primitive, immature cells. The cellular composition determines the biological behavior and clinical outcome. Three types are recognized: pineoblastoma, pineocytoma, and pineal parenchymal tumor of intermediate differentiation (Adapted from WHO.)" }, "isLeaf": false, "isRoot": false, "child_count": 3, "parents": [ { "id": 20418, "label": "neuroepithelial neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 20456 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:60215", "MESH:D018302", "NCIT:C3787", "ONCOTREE:PRNET", "UMLS:C0206715" ], "synonyms": [ "neoplasm of neuroepithelial tissue", "neoplasm of neuroepithelium", "neoplasm of the neuroepithelium", "neuroepithelial neoplasm", "neuroepithelial neoplasms", "neuroepithelial tissue neoplasm", "neuroepithelial tissue tumor", "neuroepithelial tissue tumour", "neuroepithelial tumor", "neuroepithelial tumors", "neuroepithelial tumour", "neuroepithelial tumours", "tumor of neuroepithelial tissue", "tumor of neuroepithelium", "tumor of the neuroepithelium", "tumour of neuroepithelial tissue", "tumour of neuroepithelium", "tumour of the neuroepithelium", "primary neuroepithelial tumor", "primary neuroepithelial tumour" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors." }, "child_count": 6, "reference_id": "MONDO:0021193" }, { "id": 20442, "label": "pineal body neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4223, 5067, 20429, 23822 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:237252", "NCIT:C3328", "ONCOTREE:PINT", "UMLS:C1412004" ], "synonyms": [ "neoplasm of pineal area", "neoplasm of pineal body", "neoplasm of pineal region", "neoplasm of the pineal area", "neoplasm of the pineal region", "pineal area neoplasm", "pineal area tumor", "pineal area tumour", "pineal body neoplasm (disease)", "pineal body tumor", "pineal body tumour", "pineal neoplasm", "pineal region neoplasm", "pineal region tumor", "pineal region tumour", "pineal tumor", "pineal tumour", "pinealoma", "tumor of pineal area", "tumor of pineal body", "tumor of pineal region", "tumor of the pineal area", "tumor of the pineal region", "tumour of pineal area", "tumour of pineal body", "tumour of pineal region", "tumour of the pineal area", "tumour of the pineal region" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A neoplasm (disease) that involves the pineal body." }, "child_count": 20, "reference_id": "MONDO:0021232" } ], "children": [ { "id": 5193, "label": "adult pineal parenchymal tumor", "isLeaf": false, "isRoot": false, "parents": [ 21613 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5031", "MEDGEN:83710", "NCIT:C8273", "UMLS:C0280794" ], "synonyms": [ "pineal parenchymal cell tumor", "pineal parenchymal cell tumour", "adult pineal gland neoplasm", "adult pineal gland tumor", "adult pineal gland tumour", "adult pineal parenchymal cell neoplasm", "adult pineal parenchymal cell tumor", "adult pineal parenchymal cell tumour", "adult pineal parenchymal neoplasm", "adult pineal parenchymal tumor", "parenchymal neoplasm of adult pineal gland", "parenchymal neoplasm of the adult pineal gland", "parenchymal tumor of adult pineal gland", "parenchymal tumor of the adult pineal gland", "parenchymal tumour of adult pineal gland", "parenchymal tumour of the adult pineal gland", "pineal parenchymal cell neoplasm of adults" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A pineal parenchymal cell neoplasm (pineocytoma or pineoblastoma) occurring in adults." }, "child_count": 1, "reference_id": "MONDO:0003248" }, { "id": 7894, "label": "pineal parenchymal tumor of intermediate differentiation", "isLeaf": true, "isRoot": false, "parents": [ 21613 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5030", "EFO:1000474", "GARD:0010644", "MEDGEN:234566", "NCIT:C6967", "ONCOTREE:PPTID", "Orphanet:251919", "SCTID:715904005", "UMLS:C1367859" ], "synonyms": [ "pineal parenchymal tumor of intermediate differentiation", "pineal parenchymal tumor of intermediate differentiation (morphologic abnormality)", "pineal parenchymal tumour of intermediate differentiation (morphologic abnormality)", "PPTID", "pineal parenchymal tumors of intermediate differentiation", "pineal parenchymal tumours of intermediate differentiation" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A WHO grade II or III pineal parenchymal neoplasm of intermediate-grade malignancy, affecting all ages. It is composed of diffuse sheets or large lobules of uniform cells with mild to moderate nuclear atypia and low to moderate level mitotic activity. (Adapted from WHO)" }, "child_count": 0, "reference_id": "MONDO:0006369" }, { "id": 17179, "label": "pineocytoma", "isLeaf": true, "isRoot": false, "parents": [ 3032, 20573, 21613 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0081248", "EFO:1000476", "GARD:0008207", "HP:0030407", "ICDO:9361/1", "MEDGEN:183004", "MedDRA:10035059", "NANDO:2200092", "NCIT:C6966", "ONCOTREE:PINC", "Orphanet:251912", "SCTID:255045009", "UMLS:C0917890", "icd11.foundation:2055142333" ], "synonyms": [ "Pineocytoma (WHO grade I)", "benign pinealoma", "pinealocytoma", "pineocytoma", "pineocytoma (disease)", "pineocytoma, benign" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Pineocytoma is the least aggressive form of pineal parenchymal tumors, manifesting with symptoms such as Parinaud's syndrome (a group of eye movement abnormalities and pupil dysfunction, including deficiency in upward-gaze and convergence-retraction nystagmus), headaches, balance impairment, urinary incontinence, and changes in mood and that are not known to disseminate in a diffuse manner. They are usually associated with a good prognosis." }, "child_count": 0, "reference_id": "MONDO:0016723" } ], "roots": [ { "id": 20418, "label": "neuroepithelial neoplasm" }, { "id": 20442, "label": "pineal body neoplasm" } ] }