{
  "id": 21670,
  "label": "tick-borne infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0025294",
  "properties": {
    "xrefs": [
      "MEDGEN:56488",
      "MESH:D017282",
      "UMLS:C0162700"
    ],
    "synonyms": [
      "Tick borne diseases",
      "Tick borne infections",
      "Tick-borne disease",
      "Tick-borne infection",
      "Tick-borne infections",
      "disease, Tick-borne",
      "diseases, Tick-borne",
      "infection, Tick-borne",
      "infections, Tick borne",
      "infections, Tick-borne"
    ],
    "definition": "Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 23869,
      "label": "vector-borne disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:738484",
          "MESH:D000079426",
          "UMLS:C1640363"
        ],
        "synonyms": [
          "vector-borne infection",
          "vector-borne infectious disease"
        ],
        "definition": "An infectious disease where a pathogen is carried and transmitted by another organism that acts as disease vector."
      },
      "child_count": 49,
      "reference_id": "MONDO:0100120"
    }
  ],
  "children": [
    {
      "id": 2812,
      "label": "Powassan encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        7600,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050179",
          "GARD:0022741",
          "ICD9:063.8",
          "MEDGEN:18601",
          "SCTID:416707008",
          "UMLS:C0032858",
          "icd11.foundation:1674038791"
        ],
        "synonyms": [
          "Powassan virus caused disease or disorder",
          "Powassan virus disease or disorder",
          "Powassan virus infectious disease",
          "powassan encephalitis virus infection",
          "encephalitis, powassan"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease caused by infection with Powassan virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000276"
    },
    {
      "id": 2845,
      "label": "Rickettsia helvetica spotted fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3436,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050484",
          "GARD:0022747"
        ],
        "synonyms": [
          "Rickettsia helvetica aneruptive fever",
          "Rickettsia helvetica caused disease or disorder",
          "Rickettsia helvetica disease or disorder",
          "Rickettsia helvetica infectious disease",
          "aneruptive fever"
        ],
        "definition": "A disease caused by infection with Rickettsia helvetica."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000331"
    },
    {
      "id": 3366,
      "label": "Queensland tick typhus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3436,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10784",
          "GARD:0022886",
          "ICD10CM:A77.3",
          "ICD9:082.3",
          "MEDGEN:755996",
          "SCTID:68981009",
          "UMLS:C2979888",
          "icd11.foundation:2020851679"
        ],
        "synonyms": [
          "Australian tick typhus"
        ],
        "definition": "A spotted fever that has material basis in Rickettsia australis, which is transmitted by ticks (Ixodes holocyclus). The infection has symptom fever, has symptom headache, has symptom myalgia, has symptom maculopapular rash, and has symptom lymphadenopathy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001118"
    },
    {
      "id": 3817,
      "label": "tick-borne relapsing fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8384,
        19423,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13036",
          "GARD:0022977",
          "ICD10CM:A68.1",
          "ICD9:087.1",
          "MEDGEN:20515",
          "NCIT:C34976",
          "SCTID:10301003",
          "UMLS:C0035022",
          "icd11.foundation:923521593"
        ],
        "synonyms": [
          "Relapsing fever, tick-borne"
        ],
        "definition": "An infection that is caused by certain species of Rickettsia or Borrelia, which are transmitted to humans from infected ticks; it is characterized by sudden fever, chills, headaches, myalgia, arthralgia, nausea, and possibly a rash. Symptoms usually persist for two to nine days, then disappear, with recurrence after several weeks if the patient remains untreated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001621"
    },
    {
      "id": 6844,
      "label": "human granulocytic anaplasmosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6569,
        8355,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050025",
          "EFO:0000777",
          "GARD:0000071",
          "ICD10CM:A79.82",
          "ICD9:082.49",
          "MEDGEN:96911",
          "MESH:D000712",
          "NCIT:C128425",
          "SCTID:13906002",
          "SCTID:427481004",
          "SCTID:85708001",
          "UMLS:C0483368"
        ],
        "synonyms": [
          "HGA",
          "anaplasma caused disease or disorder",
          "anaplasmoses",
          "anaplasmosis",
          "human anaplasmosis",
          "human anaplasmosis caused by Anaplasma phagocytophilum",
          "infection by Anaplasma phagocytophilum",
          "HGE",
          "human ehrlichial infection, human granulocytic type",
          "human granulocytic ehrlichiosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A tick-borne, infectious disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium that is typically transmitted to humans by ticks of the Ixodes ricinus species complex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005118"
    },
    {
      "id": 16645,
      "label": "ehrlichiosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2837,
        8355,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10242",
          "GARD:0002092",
          "ICD10CM:A77.4",
          "ICD9:082.4",
          "ICD9:082.40",
          "MEDGEN:39039",
          "MESH:D016873",
          "Orphanet:1902",
          "SCTID:240626005",
          "UMLS:C0085399",
          "icd11.foundation:1116297863"
        ],
        "definition": "An disease or disorder caused by infection with Ehrlichia."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016003"
    },
    {
      "id": 17853,
      "label": "tick-borne encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7600,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050175",
          "EFO:1001309",
          "GARD:0005216",
          "ICD10CM:A84",
          "ICD9:063.2",
          "MEDGEN:4034",
          "MESH:D004675",
          "MedDRA:10043848",
          "NCIT:C34579",
          "Orphanet:297",
          "UMLS:C0014061",
          "icd11.foundation:835129952"
        ],
        "synonyms": [
          "TBE",
          "Tick-borne viral encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Tick-borne encephalitis is caused by an arbovirus of the Flaviviridae family (tick-borne encephalitis virus, TBEV), transmitted principally by the bite of the Ixodes ricinus tick. The symptomology is biphasic, with the initial phase being associated with a flu-like illness and the second phase (occurring in less than 10% of patients) with symptoms of meningitis or, more rarely, meningoencephalitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017572"
    },
    {
      "id": 18096,
      "label": "Omsk hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        18247,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:992",
          "GARD:0008254",
          "ICD10CM:A98.1",
          "ICD9:065.1",
          "MEDGEN:9212",
          "MESH:D006481",
          "MedDRA:10030310",
          "Orphanet:319266",
          "SCTID:48113006",
          "UMLS:C0019103",
          "icd11.foundation:946068954"
        ],
        "definition": "Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is a zoonotic disease characterized by fever, nausea, myalgia and moderately severe hemorrhagic manifestations as well as in some cases meningitis, pneumonia and nephrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017882"
    },
    {
      "id": 19422,
      "label": "Lyme disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2837,
        20765,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11729",
          "EFO:0008510",
          "GARD:0027870",
          "ICD10CM:A69.2",
          "ICD9:088.81",
          "MEDGEN:44213",
          "MESH:D008193",
          "MedDRA:10025169",
          "NCIT:C45161",
          "Orphanet:91546",
          "SCTID:48982009",
          "UMLS:C0024198",
          "icd11.foundation:1600014919"
        ],
        "synonyms": [
          "Borrelia",
          "Borrelia burgdorferi infection",
          "Borreliella burgdorferi caused disease or disorder",
          "Borreliella burgdorferi disease or disorder",
          "Borreliella burgdorferi infectious disease",
          "Lyme borreliosis",
          "Lyme disease"
        ],
        "definition": "Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by Borrelia burgdorferi."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019632"
    },
    {
      "id": 25840,
      "label": "Borrelia miyamotoi disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2837,
        8148,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070527"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958150"
    }
  ],
  "roots": [
    {
      "id": 23869,
      "label": "vector-borne disease"
    }
  ]
}