{
  "id": 21745,
  "label": "Buschke Lowenstein tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0027026",
  "properties": {
    "xrefs": [
      "GARD:0009663",
      "MEDGEN:473018",
      "MESH:D062688",
      "NCIT:C6371",
      "SCTID:402910001",
      "UMLS:C0276264"
    ],
    "synonyms": [
      "Buschke Lowenstein tumor",
      "giant condyloma acuminatum involving the prepuce and glans penis",
      "giant condyloma of Buschke and Lowenstein",
      "Buschke-Lowenstein tumor",
      "Buschke-Lowenstein tumour",
      "GCBL",
      "Giant condyloma Acuminatum",
      "Giant condyloma Acuminatums",
      "Giant condyloma of Buschke and Lowenstein",
      "Lowenstein tumor, Buschke",
      "anogenital type verrucous carcinoma",
      "condyloma Acuminatum, Giant",
      "condyloma Acuminatums, Giant",
      "tumor, Buschke Lowenstein",
      "tumor, Buschke-Lowenstein"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A verrucous carcinoma of the skin or mucosa that occurs in the anogenital region."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4279,
      "label": "reproductive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:193",
          "MEDGEN:233668",
          "NCIT:C36076",
          "UMLS:C1334618"
        ],
        "synonyms": [
          "reproductive tumor",
          "reproductive tumour",
          "cancer of reproductive organ",
          "cancer of reproductive system",
          "malignant neoplasm of reproductive organ",
          "malignant neoplasm of reproductive system",
          "malignant reproductive organ neoplasm",
          "malignant reproductive system neoplasm",
          "reproductive organ cancer",
          "reproductive system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the reproductive organ"
      },
      "child_count": 16,
      "reference_id": "MONDO:0002149"
    },
    {
      "id": 7283,
      "label": "anogenital human papillomavirus infection",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6884,
        20727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11168",
          "EFO:0007147",
          "ICD9:078.11",
          "MEDGEN:108217",
          "MESH:D003218",
          "NCIT:C4820",
          "SCTID:266113007",
          "UMLS:C0554632"
        ],
        "synonyms": [
          "anogenital Human Papillomavirus infection",
          "anogenital Human papilloma Virus infection",
          "condyloma acuminatum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sexually transmitted papillary growth caused by the human papillomavirus. It usually arises in the skin and mucous membranes of the perianal region and external genitalia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005647"
    },
    {
      "id": 7597,
      "label": "verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3737",
          "EFO:0007535",
          "ICD9:199.1",
          "ICDO:8051/3",
          "MEDGEN:60213",
          "MESH:D018289",
          "NCIT:C3781",
          "SCTID:403904009",
          "UMLS:C0206706"
        ],
        "synonyms": [
          "verrucous carcinoma",
          "verrucous carcinoma NOS (morphologic abnormality)",
          "verrucous epidermoid carcinoma",
          "verrucous epidermoid cell carcinoma",
          "verrucous squamous carcinoma",
          "verrucous squamous cell carcinoma",
          "warty carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006006"
    }
  ],
  "children": [
    {
      "id": 5960,
      "label": "anal verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7659,
        21745,
        23208
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7175",
          "GARD:0023840",
          "MEDGEN:231066",
          "NCIT:C7470",
          "UMLS:C1332278"
        ],
        "synonyms": [
          "anal Buschke-Lowenstein tumor",
          "anal Buschke-Lowenstein tumour",
          "anal giant (malignant) condyloma",
          "anal verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A large, well differentiated squamous cell carcinoma with a cauliflower-like appearance, characterized by the presence of an exophytic and endophytic growth pattern. Morphologically, there is papillomatosis and acanthosis present, however cytologically the neoplastic squamous cells have a benign appearance. Dysplastic changes are minimal. It does not respond to conservative treatment and it is regarded by many authors as an intermediate lesion between condyloma acuminatum and squamous cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004131"
    }
  ],
  "roots": [
    {
      "id": 4279,
      "label": "reproductive system cancer"
    },
    {
      "id": 7283,
      "label": "anogenital human papillomavirus infection"
    },
    {
      "id": 7597,
      "label": "verrucous carcinoma"
    }
  ]
}