{
  "id": 22128,
  "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0030923",
  "properties": {
    "xrefs": [
      "GARD:0025663",
      "OMIMPS:105500"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 21292,
      "label": "inherited neurodegenerative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020280",
          "MEDGEN:1825988",
          "MESH:D020271",
          "NCIT:C97073",
          "Orphanet:183500",
          "UMLS:C5680568"
        ],
        "synonyms": [
          "genetic neurodegenerative disease",
          "hereditary neurodegenerative disease",
          "hereditary neurodegenerative disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An inherited disorder characterized by progressive degeneration and atrophy of the nervous system."
      },
      "child_count": 164,
      "reference_id": "MONDO:0024237"
    }
  ],
  "children": [
    {
      "id": 8518,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060213",
          "GARD:0018396",
          "MEDGEN:1830423",
          "NCIT:C168756",
          "OMIM:105550",
          "UMLS:C5779877"
        ],
        "synonyms": [
          "ALSFTD",
          "C9ORF72 frontotemporal dementia with motor neuron disease",
          "C9orf72 frontotemporal dementia with motor neuron disease",
          "FTDMND",
          "amyotrophic lateral sclerosis and/or frontotemporal dementia",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 1",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 1",
          "frontotemporal dementia and/or motor neuron disease",
          "frontotemporal dementia with motor neuron disease caused by mutation in C9ORF72",
          "frontotemporal dementia with motor neuron disease caused by mutation in C9orf72",
          "FTDALS1",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any frontotemporal dementia with motor neuron disease in which the cause of the disease is a mutation in the C9orf72 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007105"
    },
    {
      "id": 12067,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17505,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060208",
          "DOID:0111227",
          "GARD:0015322",
          "ICD9:331.19",
          "MEDGEN:318833",
          "MESH:C563708",
          "MESH:C579991",
          "OMIM:600795",
          "OMIM:614696",
          "SCTID:702393003",
          "UMLS:C1833296"
        ],
        "synonyms": [
          "CHMP2B amyotrophic lateral sclerosis",
          "CHMP2B-related amyotrophic lateral sclerosis",
          "FTD3",
          "amyotrophic lateral sclerosis caused by mutation in CHMP2B",
          "amyotrophic lateral sclerosis, Chmp2B-related",
          "frontotemporal dementia, chromosome 3-linked",
          "Dmt1",
          "dementia, familial nonspecific"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the CHMP2B gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010936"
    },
    {
      "id": 14531,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060205",
          "GARD:0015733",
          "MEDGEN:1759760",
          "OMIM:613954",
          "UMLS:C5436279"
        ],
        "synonyms": [
          "VCP amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in VCP"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013501"
    },
    {
      "id": 15397,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060214",
          "GARD:0018397",
          "MEDGEN:863085",
          "OMIM:615911",
          "UMLS:C4014648"
        ],
        "synonyms": [
          "FTDALS2",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 2",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the CHCHD10 gene on chromosome 22. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014395"
    },
    {
      "id": 15636,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17505,
        17506,
        22128,
        25050
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110068",
          "GARD:0016113",
          "MEDGEN:897127",
          "OMIM:616437",
          "UMLS:C4225326"
        ],
        "synonyms": [
          "FTDALS3",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 3",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the SQSTM1 gene on chromosome 5q35."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014640"
    },
    {
      "id": 15637,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110069",
          "GARD:0018398",
          "MEDGEN:902979",
          "OMIM:616439",
          "UMLS:C4225325"
        ],
        "synonyms": [
          "FTDALS4",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the TBK1 gene on chromosome 12q14."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014641"
    },
    {
      "id": 22086,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018395",
          "MEDGEN:1728824",
          "OMIM:619132",
          "UMLS:C5436881"
        ],
        "synonyms": [
          "FTDALS8",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030872"
    },
    {
      "id": 22088,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016427",
          "MEDGEN:1756201",
          "OMIM:619141",
          "UMLS:C5436884"
        ],
        "synonyms": [
          "FTDALS5",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030875"
    }
  ],
  "roots": [
    {
      "id": 21292,
      "label": "inherited neurodegenerative disorder"
    }
  ]
}