{
  "id": 22231,
  "label": "high altitude pulmonary edema",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0031257",
  "properties": {
    "xrefs": [
      "GARD:0021502",
      "MEDGEN:137935",
      "Orphanet:330012",
      "UMLS:C0340100"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A rare pulmonary condition characterized by non-cardiogenic pulmonary edema occurring in otherwise healthy individuals within days of an ascent above 2500-3000 m. Early symptoms include exertional dyspnea, non-productive cough, chest tightness, and reduced exercise performance, followed by dyspnea at rest and possibly orthopnea, as well as gurgling in the chest and pink frothy sputum in advanced cases. Clinical signs are cyanosis, tachypnea, tachycardia, crackles or wheezing, and elevated body temperature (generally not exceeding 38.5°C). Signs of concomitant high-altitude cerebral edema may also be observed. Chest x-rays typically show patchy opacities predominantly in the right middle lobe."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 8364,
      "label": "pulmonary edema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11396",
          "EFO:1001134",
          "ICD10CM:J81",
          "MEDGEN:11026",
          "MESH:D011654",
          "MedDRA:10037375",
          "NCIT:C26868",
          "SCTID:19242006",
          "UMLS:C0034063"
        ],
        "synonyms": [
          "edema, pulmonary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure)."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006932"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 8364,
      "label": "pulmonary edema"
    }
  ]
}