{
  "id": 22754,
  "label": "pediatric-onset Graves disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0033925",
  "properties": {
    "xrefs": [
      "GARD:0022190",
      "MEDGEN:1842979",
      "Orphanet:525731",
      "UMLS:C5680179"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A rare endocrine disease characterized by the presence of serum autoantibodies against thyroid-stimulating hormone receptors, leading to excessive thyroid hormone production and a swollen thyroid gland. Children with this disease typically experience symptoms of an overactive thyroid, including rapid heartbeat, weight loss, tremors, and excessive sweating."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7047,
      "label": "Graves disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3354,
        7262,
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12361",
          "EFO:0004237",
          "ICD9:242.0",
          "MEDGEN:6677",
          "MESH:D006111",
          "NANDO:2200328",
          "NCIT:C3071",
          "SCTID:353295004",
          "UMLS:C0018213"
        ],
        "synonyms": [
          "Graves disease",
          "Basedow disease",
          "Graves' hyperthyroidism",
          "parry disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005364"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7047,
      "label": "Graves disease"
    }
  ]
}