{
  "id": 22815,
  "label": "vegetative pyoderma gangrenosum",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035238",
  "properties": {
    "xrefs": [
      "GARD:0022223",
      "MEDGEN:1842944",
      "Orphanet:538872",
      "UMLS:C5680158"
    ],
    "synonyms": [
      "Granulomatous pyoderma gangrenosum"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A rare subtype of pyoderma gangrenosum disease characterized by a solitary, erythematous, ulcerated plaque, which lacks the violaceous border typically present in classic pyoderma gangrenosum, usually affecting individuals who are otherwise healthy. Histologically, the lesion presents a central layer containing neutrophilic inflammation, surrounded by a palisade of histiocytes, which are rimmed by a lymphocytic infiltrate. In comparison with the other variants of pyoderma gangrenosum, this subtype usually shows a good response to less aggressive treatments and underlying systemic disorders are less frequently associated. It is considered the most benign and uncommon clinical variant of pyoderma gangrenosum."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18765,
      "label": "pyoderma gangrenosum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4929,
        19503
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8553",
          "GARD:0007510",
          "ICD10CM:L88",
          "ICD10WHO:L88",
          "ICD9:686.01",
          "MEDGEN:43224",
          "MESH:D017511",
          "MedDRA:10037635",
          "NANDO:2200437",
          "NORD:1638",
          "Orphanet:48104",
          "SCTID:74578003",
          "UMLS:C0085652",
          "icd11.foundation:2120746218"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Pyoderma gangrenosum (PG) is a primarily sterile inflammatory neutrophilic dermatosis characterized by recurrent cutaneous ulcerations with a mucopurulent or hemorrhagic exudate."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018824"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18765,
      "label": "pyoderma gangrenosum"
    }
  ]
}