{
  "id": 22825,
  "label": "chronic bilirubin encephalopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035345",
  "properties": {
    "xrefs": [
      "GARD:0022198",
      "MEDGEN:1806573",
      "Orphanet:529808",
      "UMLS:C5575229"
    ],
    "synonyms": [
      "BIND",
      "Bilirubin-induced neurological dysfunction",
      "CBE",
      "KSD",
      "Kernicterus spectrum disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare neurologic disease characterized by the chronic consequences of bilirubin toxicity in the globus pallidus, sub-thalamic nuclei, and other brain regions, after exposure to high levels of unconjugated bilirubin in the neonatal period. Symptoms begin after the acute phase of bilirubin encephalopathy in the first year of life, evolve slowly over several years, and include mild to severe extrapyramidal disturbances (especially dystonia and athetosis), auditory neuropathy spectrum disorder, and oculomotor and dental abnormalities."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7181,
      "label": "toxic encephalopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3602",
          "EFO:0005595",
          "GARD:0007199",
          "ICD10CM:G92",
          "ICD10WHO:G92",
          "ICD9:349.82",
          "MESH:D020258",
          "NCIT:C27961",
          "SCTID:28394000",
          "Wikipedia:Toxic_encephalopathy"
        ],
        "synonyms": [
          "neurotoxicity",
          "neurotoxicity syndrome",
          "neurotoxicity syndromes"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005527"
    },
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7181,
      "label": "toxic encephalopathy"
    },
    {
      "id": 7209,
      "label": "brain disorder"
    }
  ]
}