{
  "id": 22832,
  "label": "seronegative autoimmune hepatitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035400",
  "properties": {
    "xrefs": [
      "GARD:0022253",
      "MEDGEN:1804383",
      "Orphanet:563589",
      "UMLS:C5680121"
    ],
    "synonyms": [
      "Seronegative AIH",
      "autoantibody-negative autoimmune hepatitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A form of autoimmune hepatitis characterized by the features of classic autoimmune hepatitis (i. e. clinical presentation as acute or chronic cryptogenic hepatitis, interface hepatitis on histological examination, elevated serum aspartate aminotransferase and alanine aminotransferase levels, hypergammaglobulinemia/elevated immunoglobulin G, therapeutic response to corticosteroids) in the absence of serum autoantibodies. Clinical manifestations include fatigue, malaise, arthralgia, jaundice, at later stages also signs of advanced chronic liver disease, such as spider nevi, caput medusae, splenomegaly, ascites, and palmar erythema. Presence of concurrent autoimmune diseases is frequently observed."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16828,
      "label": "autoimmune hepatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        3002,
        3004,
        4367
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2048",
          "EFO:0005676",
          "GARD:0005871",
          "ICD10CM:K75.4",
          "ICD9:571.42",
          "MEDGEN:1666753",
          "MESH:D019693",
          "MedDRA:10003827",
          "NANDO:1200441",
          "NANDO:1200442",
          "NANDO:2100264",
          "NCIT:C27029",
          "NORD:1897",
          "Orphanet:2137",
          "SCTID:408335007",
          "UMLS:C4721555",
          "icd11.foundation:1235727122"
        ],
        "synonyms": [
          "autoimmune liver disease",
          "autoimmune hepatitis",
          "autoimmune chronic active hepatitis",
          "autoimmune hepatitis with centrilobular necrosis",
          "chronic autoimmune hepatitis",
          "AIH",
          "autoimmune chronic hepatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hepatitis caused by autoantibodies. Drugs, infections, and toxins may trigger the production of the autoantibodies against the liver parenchyma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0016264"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16828,
      "label": "autoimmune hepatitis"
    }
  ]
}