{
  "id": 22848,
  "label": "chronic mast cell leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035445",
  "properties": {
    "xrefs": [
      "GARD:0022277",
      "ICD10CM:C94.3",
      "MEDGEN:1843226",
      "Orphanet:566396",
      "UMLS:C5680130"
    ],
    "synonyms": [
      "Chronic MCL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare form of mast cell leukemia characterized by the presence of at least 20% mast cells in bone marrow aspirate smears but often mature mast cell morphology, low proliferation rate, and absence of organ damage and C findings (cytopenias, hepatomegaly, ascites, portal hypertension, splenomegaly, skeletal lesions, malabsorption). The disease course is less aggressive than in the acute form, although patients may later progress."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 9280,
      "label": "mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4762,
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:350",
          "EFO:0009001",
          "GARD:0006987",
          "ICD10WHO:Q82.2",
          "MEDGEN:9902",
          "MESH:D008415",
          "MedDRA:10026891",
          "NCIT:C84269",
          "NORD:1408",
          "ONCOTREE:MCD",
          "Orphanet:98292",
          "UMLS:C0024899",
          "icd11.foundation:691643472"
        ],
        "synonyms": [
          "Mast cell disease",
          "mastocytosis",
          "MAST cell disease",
          "urticaria pigmentosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0007950"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 9280,
      "label": "mastocytosis"
    }
  ]
}