{
  "id": 22917,
  "label": "idiopathic multicentric Castleman disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035838",
  "properties": {
    "xrefs": [
      "GARD:0022309",
      "MEDGEN:1680858",
      "Orphanet:570431",
      "UMLS:C5197665"
    ],
    "synonyms": [
      "HHV-8-negative multicentric Castleman disease",
      "Human herpesvirus-8-negative multicentric Castleman disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 16372,
      "label": "Castleman disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111157",
          "GARD:0012656",
          "ICD10CM:D47.Z2",
          "MEDGEN:42211",
          "MESH:D005871",
          "MedDRA:10050251",
          "NCIT:C3056",
          "NORD:898",
          "Orphanet:160",
          "SCTID:207036003",
          "UMLS:C0017531",
          "icd11.foundation:1940989685"
        ],
        "synonyms": [
          "AFLH",
          "Castleman disease",
          "Castleman's disease",
          "Castleman's tumor",
          "Castleman's tumour",
          "GLNH",
          "angiofollicular ganglionic hyperplasia",
          "angiofollicular lymph hyperplasia",
          "angiofollicular lymph node hyperplasia",
          "angiofollicular lymphoid hyperplasia",
          "giant lymph node hyperplasia",
          "ALNH"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015564"
    }
  ],
  "children": [
    {
      "id": 18688,
      "label": "Castleman-Kojima disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18157,
        22917
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021902",
          "MEDGEN:1672503",
          "Orphanet:457077",
          "UMLS:C4552543",
          "icd11.foundation:1505841618"
        ],
        "synonyms": [
          "TAFRO syndrome",
          "thrombocytopenia-anasarca-fever-renal insufficiency-organomegaly syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A clinicopathologic variant of multicentric Castleman's disease characterized by thrombocytopenia, ascites (anasarca), microcytic anemia, myelofibrosis, renal dysfunction, and organomegaly"
      },
      "child_count": 0,
      "reference_id": "MONDO:0018702"
    }
  ],
  "roots": [
    {
      "id": 16372,
      "label": "Castleman disease"
    }
  ]
}