{
  "id": 22955,
  "label": "malignant phyllodes tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0037003",
  "properties": {
    "xrefs": [
      "ICDO:9020/3",
      "MEDGEN:109372",
      "NCIT:C4275",
      "UMLS:C0600066"
    ],
    "synonyms": [
      "malignant cystosarcoma phyllodes",
      "malignant phyllodes neoplasm",
      "malignant phyllodes tumor",
      "phyllodes tumor, malignant"
    ],
    "definition": "A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, or rhabdomyosarcomatous differentiation may also occur in the stroma. It may recur and metastasize following surgical resection. The lung and skeleton are the anatomic sites most frequently involved by metastases."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6806,
      "label": "phyllodes tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20289
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000653",
          "MEDGEN:1209",
          "MESH:D003557",
          "NCIT:C2977",
          "UMLS:C0010701"
        ],
        "synonyms": [
          "CSP",
          "cystosarcoma phyllodes",
          "phyllodes neoplasm",
          "phyllodes tumor"
        ],
        "definition": "A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005078"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:154",
          "EFO:1000356",
          "ICDO:8940/3",
          "MEDGEN:64618",
          "MESH:D018198",
          "NCIT:C3729",
          "UMLS:C0206625"
        ],
        "synonyms": [
          "mixed cell type cancer",
          "mixed neoplasm",
          "mixed tumor",
          "mixed tumour",
          "malignant mixed neoplasm",
          "malignant mixed tumor",
          "malignant mixed tumour",
          "mixed neoplasm, malignant",
          "mixed tumor, malignant (morphologic abnormality)",
          "mixed tumor, malignant, NOS (morphologic abnormality)",
          "tumor, mixed, malignant",
          "malignant mixed tumors",
          "malignant mixed tumours",
          "mixed tumors, malignant",
          "tumor, malignant mixed",
          "tumors, malignant mixed"
        ],
        "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005853"
    }
  ],
  "children": [
    {
      "id": 3260,
      "label": "malignant prostate phyllodes tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7836,
        9621,
        20342,
        22955
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10289",
          "GARD:0022859",
          "MEDGEN:235301",
          "NCIT:C5531",
          "UMLS:C1334615"
        ],
        "synonyms": [
          "malignant phyllodes neoplasm of prostate",
          "malignant phyllodes neoplasm of the prostate",
          "malignant phyllodes tumor of prostate",
          "malignant phyllodes tumor of the prostate",
          "malignant phyllodes tumour of prostate",
          "malignant phyllodes tumour of the prostate",
          "malignant prostate phyllodes neoplasm",
          "malignant prostate phyllodes tumor",
          "prostate malignant phyllodes tumor",
          "prostate malignant phyllodes tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An unusual malignant tumor that arises from the prostate gland. It is characterized by the presence of glandular elements and a cellular stroma that exhibits mitotic activity and nuclear atypia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000994"
    },
    {
      "id": 4568,
      "label": "malignant breast phyllodes tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8659,
        20291,
        22955
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3016",
          "EFO:0008545",
          "GARD:0023148",
          "MEDGEN:87543",
          "NCIT:C4504",
          "ONCOTREE:MPT",
          "SCTID:254844000",
          "UMLS:C0346154",
          "icd11.foundation:147026376"
        ],
        "synonyms": [
          "malignant phyllodes neoplasm",
          "phyllodes breast neoplasm",
          "phyllodes breast tumor",
          "phyllodes breast tumour",
          "phyllodes tumor, malignant (morphologic abnormality)",
          "breast phyllodes tumor, malignant",
          "malignant breast phyllodes neoplasm",
          "malignant breast phyllodes tumor",
          "malignant cystosarcoma phyllodes of breast",
          "malignant cystosarcoma phyllodes of the breast",
          "malignant mammary phyllodes neoplasm",
          "malignant mammary phyllodes tumor",
          "malignant phyllodes breast neoplasm",
          "malignant phyllodes neoplasm of breast",
          "malignant phyllodes neoplasm of the breast",
          "malignant phyllodes tumor (morphologic abnormality)",
          "malignant phyllodes tumor of breast",
          "malignant phyllodes tumor of the breast",
          "malignant phyllodes tumour (morphologic abnormality)",
          "malignant phyllodes tumour of breast",
          "malignant phyllodes tumour of the breast",
          "breast malignant phyllodes tumor",
          "breast malignant phyllodes tumour",
          "malignant cystosarcoma phyllodes",
          "malignant cystosarcoma phyllodes (morphologic abnormality)",
          "malignant phyllodes tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A phyllodes tumor of the breast characterized by infiltrative margins and a sarcomatous stromal component. The sarcomatous stroma usually displays features of fibrosarcoma. Liposarcomatous, osteosarcomatous, or rhabdomyosarcomatous elements may also be present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002489"
    }
  ],
  "roots": [
    {
      "id": 6806,
      "label": "phyllodes tumor"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm"
    }
  ]
}