{
  "id": 22991,
  "label": "inherited auditory system disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0037940",
  "properties": {
    "xrefs": [
      "MEDGEN:707712",
      "SCTID:362991006",
      "UMLS:C1285174"
    ],
    "synonyms": [
      "auditory system hereditary disorder",
      "hereditary auditory system disease",
      "inherited auditory system disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0002409",
        "name": "auditory system disorder"
      }
    ],
    "definition": "An instance of auditory system disease that is caused by an inherited modification of the individual's genome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4499,
      "label": "auditory system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2742",
          "EFO:1001455",
          "ICD10CM:H60-H95",
          "MEDGEN:1846617",
          "SCTID:362966006",
          "UMLS:C5848260"
        ],
        "synonyms": [
          "auditory disease",
          "auditory system disease",
          "auditory system disease or disorder",
          "disease of auditory system",
          "disease or disorder of auditory system",
          "disorder of auditory system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          }
        ],
        "definition": "A disease involving the auditory system."
      },
      "child_count": 11,
      "reference_id": "MONDO:0002409"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    }
  ],
  "children": [
    {
      "id": 7034,
      "label": "otosclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12185",
          "EFO:0004213",
          "GARD:0027719",
          "HP:0000362",
          "ICD10CM:H80",
          "ICD10WHO:H80",
          "ICD9:387",
          "ICD9:387.8",
          "ICD9:387.9",
          "MEDGEN:10508",
          "MESH:D010040",
          "NCIT:C185242",
          "OMIMPS:166800",
          "Orphanet:2794",
          "SCTID:11543004",
          "UMLS:C0029899",
          "icd11.foundation:1242649410"
        ],
        "synonyms": [
          "otosclerosis",
          "otosclerosis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs."
      },
      "child_count": 33,
      "reference_id": "MONDO:0005349"
    },
    {
      "id": 9300,
      "label": "Meniere disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8201,
        18718,
        22991,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9849",
          "EFO:0006862",
          "ICD9:386.0",
          "ICD9:386.00",
          "MEDGEN:7530",
          "MESH:D008575",
          "NCIT:C185243",
          "OMIM:156000",
          "Orphanet:45360",
          "SCTID:13445001",
          "UMLS:C0025281",
          "icd11.foundation:683932278"
        ],
        "synonyms": [
          "Meniere disease",
          "Meniere's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A disease of the inner ear (labyrinth) that is characterized by fluctuating sensorineural hearing loss; tinnitus; episodic vertigo; and aural fullness. It is the most common form of endolymphatic hydrops."
      },
      "child_count": 12,
      "reference_id": "MONDO:0007972"
    },
    {
      "id": 9341,
      "label": "motion sickness",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2951",
          "ICD10CM:T75.3",
          "ICD9:994.6",
          "MEDGEN:44503",
          "MESH:D009041",
          "OMIM:158280",
          "UMLS:C0026603",
          "icd11.foundation:1078108554"
        ],
        "synonyms": [
          "motion sickness",
          "travel sickness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A sensation of discomfort that results from a discordant relationship between visualized movement and any movement sensed by the vestibular system, which is characterized by dizziness, nausea, and vomiting."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008015"
    },
    {
      "id": 10705,
      "label": "Johanson-Blizzard syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4427,
        7048,
        7611,
        16087,
        22991,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14694",
          "GARD:0000080",
          "ICD9:759.89",
          "MEDGEN:59798",
          "MESH:C535880",
          "MESH:C564907",
          "NORD:1311",
          "OMIM:243800",
          "OMIM:260450",
          "Orphanet:2315",
          "SCTID:75979009",
          "UMLS:C0175692",
          "icd11.foundation:1427330812"
        ],
        "synonyms": [
          "JBS",
          "Johanson-Blizzard syndrome",
          "pancreatic insufficiency, combined exocrine",
          "Johanson-BLIZZARD syndrome",
          "nasal alar hypoplasia, hypothyroidism, pancreatic achylia and congenital deafness",
          "nasal alar hypoplasia, hypothyroidism, pancreatic achylia, and congenital deafness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A multiple congenital anomaly characterized by exocrine pancreatic insufficiency, hypoplasia/aplasia of the nasal alae, hypodontia, sensorineural hearing loss, growth retardation, anal and urogenital malformations, and variable intellectual disability."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009479"
    },
    {
      "id": 13950,
      "label": "age-related hearing impairment 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        22991,
        23243,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:382794",
          "MESH:C567305",
          "OMIM:612448",
          "UMLS:C2676230"
        ],
        "synonyms": [
          "ARHI1",
          "age-related hearing impairment 1",
          "presbycusis 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012910"
    },
    {
      "id": 14106,
      "label": "age-related hearing impairment 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        22991,
        23243,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:416639",
          "MESH:C567834",
          "OMIM:612976",
          "UMLS:C2751814"
        ],
        "synonyms": [
          "ARHI2",
          "age-related hearing impairment 2",
          "presbycusis 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013068"
    },
    {
      "id": 19315,
      "label": "nonsyndromic genetic hearing loss",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7048,
        22991,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050563",
          "MEDGEN:1830101",
          "MESH:C580334",
          "Orphanet:87884",
          "UMLS:C5680182",
          "icd11.foundation:1154032108"
        ],
        "synonyms": [
          "nonsyndromic deafness",
          "nonsyndromic hearing loss",
          "nonsyndromic genetic hearing loss",
          "familial deafness",
          "isolated genetic deafness",
          "non-syndromic genetic deafness",
          "nonsyndromic genetic deafness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease characterized by hearing loss that is not part of a larger syndrome."
      },
      "child_count": 18,
      "reference_id": "MONDO:0019497"
    },
    {
      "id": 20169,
      "label": "X-linked deafness",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2902,
        7048,
        22991,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "OMIMPS:304500"
        ],
        "synonyms": [
          "DFNX",
          "X-linked deafness",
          "deafness, X-linked",
          "deafness, X-linked, DFN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020768"
    },
    {
      "id": 20787,
      "label": "auditory neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7048,
        22991,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009274",
          "MEDGEN:338895",
          "MESH:C538268",
          "NCIT:C116364",
          "OMIMPS:609129",
          "SCTID:443805006",
          "UMLS:C1852271"
        ],
        "synonyms": [
          "ANSD",
          "auditory dys-synchrony",
          "auditory neuropathy",
          "auditory neuropathy spectrum disorder",
          "familial auditory neuropathy",
          "progressive auditory neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hearing disorder characterized by impaired transmission of signals through the auditory nerve, resulting in mild to severe hearing loss and poor speech perception."
      },
      "child_count": 15,
      "reference_id": "MONDO:0021944"
    },
    {
      "id": 21266,
      "label": "tympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7791,
        16045,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008658",
          "GTR:AN0102047",
          "GTR:AN0102048",
          "MEDGEN:105375",
          "MESH:D043604",
          "NCIT:C8428",
          "SCTID:253031000",
          "UMLS:C0474820"
        ],
        "synonyms": [
          "tympanic paraganglioma",
          "Glomus Tympanicum Tumor",
          "Glomus Tympanicum Tumors",
          "Glomus Tympanicum Tumour",
          "Glomus Tympanicum Tumours",
          "Glomus tympanicum paraganglioma",
          "Glomus tympanicum tumor",
          "Glomus tympanicum tumour",
          "Tumor, Glomus Tympanicum",
          "Tumors, Glomus Tympanicum",
          "Tympanic Paraganglioma",
          "Tympanic paraganglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A benign or malignant middle ear paraganglioma arising from paraganglia around the tympanum. Signs and symptoms include a mass behind the tympanum, tinnitus, and conductive hearing loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023682"
    },
    {
      "id": 29399,
      "label": "benign paroxysmal positional vertigo",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6654,
        18718,
        22991,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13941",
          "ICD9:386.11",
          "MEDGEN:57837",
          "MESH:D065635",
          "OMIM:193007",
          "SCTID:111541001",
          "UMLS:C0155502"
        ],
        "synonyms": [
          "BPPV",
          "BRV",
          "benign paroxysmal positional vertigo",
          "familial benign recurrent vertigo",
          "familial vestibulopathy",
          "vertigo, benign paroxysmal positional",
          "vertigo, benign recurrent",
          "vestibulopathy, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Idiopathic recurrent vertigo associated with positional nystagmus. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in labyrinthitis and vestibular neuronitis inflammation in the ear is not observed."
      },
      "child_count": 0,
      "reference_id": "MONDO:8000018"
    },
    {
      "id": 29400,
      "label": "vertigo, benign recurrent, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6654,
        18718,
        22991,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027039",
          "MEDGEN:412807",
          "MESH:C567620",
          "UMLS:C2749845"
        ],
        "synonyms": [
          "BRV1",
          "vertigo, benign recurrent, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:8000019"
    }
  ],
  "roots": [
    {
      "id": 4499,
      "label": "auditory system disorder"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    }
  ]
}