{
  "id": 23004,
  "label": "invasive carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0040677",
  "properties": {
    "xrefs": [
      "MEDGEN:233579",
      "NCIT:C9480",
      "UMLS:C1334274"
    ],
    "synonyms": [
      "invasive carcinoma"
    ],
    "definition": "A carcinoma that is not confined to the epithelium, and has spread to the surrounding stroma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 4575,
      "label": "submucosal invasive colon adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4386,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3038",
          "MEDGEN:271523",
          "NCIT:C38760",
          "UMLS:C1515024"
        ],
        "synonyms": [
          "submucosal invasive colon adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma of the colon that has invaded into the submucosa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002496"
    },
    {
      "id": 4650,
      "label": "invasive malignant thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7956,
        7959,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3283",
          "GARD:0023180",
          "MEDGEN:78892",
          "NCIT:C7904",
          "UMLS:C0278846"
        ],
        "synonyms": [
          "invasive malignant thymoma",
          "malignant thymoma, invasive",
          "thymoma malignant invasive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant thymoma that extends beyond the capsule and infiltrates the surrounding tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002592"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000307",
          "MEDGEN:163435",
          "NCIT:C9245",
          "ONCOTREE:BRCA",
          "SCTID:713609000",
          "UMLS:C0853879",
          "icd11.foundation:2090549892"
        ],
        "synonyms": [
          "infiltrating breast cancer",
          "infiltrating breast carcinoma",
          "infiltrating carcinoma of breast",
          "infiltrating carcinoma of the breast",
          "invasive breast cancer",
          "invasive breast carcinoma",
          "invasive carcinoma of breast",
          "invasive carcinoma of the breast",
          "invasive mammary carcinoma",
          "BRCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006256"
    },
    {
      "id": 23005,
      "label": "infiltrating urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        21366,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:268274",
          "NCIT:C39853",
          "UMLS:C1512751"
        ],
        "synonyms": [
          "infiltrating transitional cell carcinoma of the urinary tract",
          "infiltrating urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A invasive carcinoma that involves the urothelium."
      },
      "child_count": 6,
      "reference_id": "MONDO:0040678"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}