{
  "id": 23006,
  "label": "urothelial carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0040679",
  "properties": {
    "xrefs": [
      "EFO:0008528",
      "GARD:0025829",
      "MEDGEN:760495",
      "NCIT:C4030",
      "UMLS:C2145472"
    ],
    "synonyms": [
      "Uroepithelial carcinoma",
      "transitional cell car. -uroth.",
      "transitional cell carcinoma of the urinary tract",
      "transitional cell carcinoma of the urothelial tract",
      "urothelial carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7836,
      "label": "malignant urinary system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20307
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3996",
          "EFO:1000363",
          "ICD10CM:C64-C68",
          "ICD9:189.9",
          "MEDGEN:738719",
          "NCIT:C192668",
          "NCIT:C9297",
          "SCTID:448233000",
          "UMLS:C1644719"
        ],
        "synonyms": [
          "cancer of renal system",
          "malignant neoplasm of renal system",
          "malignant renal system neoplasm",
          "malignant urinary system neoplasm",
          "malignant urinary tract neoplasm",
          "renal system cancer",
          "urinary system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas."
      },
      "child_count": 20,
      "reference_id": "MONDO:0006295"
    },
    {
      "id": 7972,
      "label": "transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2671",
          "EFO:1000601",
          "GARD:0007794",
          "ICDO:8120/3",
          "MEDGEN:2875",
          "MESH:D002295",
          "NCIT:C2930",
          "UMLS:C0007138"
        ],
        "synonyms": [
          "transitional cell neoplasm",
          "transitional cell tumor",
          "transitional cell tumour",
          "carcinoma of transitional epithelial cell",
          "carcinoma of urothelial cell",
          "carcinoma, urothelial, malignant",
          "transitional carcinoma",
          "transitional cell carcinoma",
          "transitional epithelial cell carcinoma",
          "urothelial cell carcinoma"
        ],
        "definition": "A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006474"
    },
    {
      "id": 21366,
      "label": "urothelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20307,
        22962
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:275551",
          "NCIT:C39852",
          "UMLS:C1519840"
        ],
        "synonyms": [
          "neoplasm of urothelium",
          "transitional cell neoplasm of the urinary tract",
          "tumor of urothelium",
          "tumour of urothelium",
          "urothelial neoplasm",
          "urothelium neoplasm",
          "urothelium neoplasm (disease)",
          "urothelium tumor",
          "urothelium tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A neoplasm involving a urothelium."
      },
      "child_count": 10,
      "reference_id": "MONDO:0024337"
    }
  ],
  "children": [
    {
      "id": 4853,
      "label": "urethra transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20506,
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4013",
          "GARD:0023262",
          "MEDGEN:167840",
          "NCIT:C6166",
          "ONCOTREE:UCU",
          "UMLS:C0863015"
        ],
        "synonyms": [
          "transitional cell carcinoma of the urethra",
          "transitional cell carcinoma of urethra",
          "urethra transitional cell carcinoma",
          "urethral transitional cell carcinoma",
          "urethral urothelial cancer",
          "urethral urothelial carcinoma",
          "UCU"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma that arises from the male or female urethra."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002836"
    },
    {
      "id": 7252,
      "label": "bladder transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6727,
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4006",
          "EFO:0006544",
          "MEDGEN:76013",
          "NCIT:C39851",
          "ONCOTREE:BLCA",
          "SCTID:255109008",
          "UMLS:C0279680"
        ],
        "synonyms": [
          "bladder transitional cell carcinoma",
          "bladder urothelial cancer",
          "bladder urothelial carcinoma",
          "transitional cell carcinoma of the urinary bladder",
          "urinary bladder transitional cell carcinoma",
          "urinary bladder urothelial carcinoma",
          "urothelial carcinoma of the urinary bladder",
          "BLCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005611"
    },
    {
      "id": 16795,
      "label": "non-papillary transitional cell carcinoma of the bladder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020447",
          "Orphanet:209989",
          "icd11.foundation:1541108245"
        ],
        "synonyms": [
          "non-papillary urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016211"
    },
    {
      "id": 20068,
      "label": "renal pelvis/ureter urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009376",
          "NCIT:C7716",
          "ONCOTREE:UTUC",
          "Orphanet:598216"
        ],
        "synonyms": [
          "TCC of renal pelvis and ureter",
          "TCC of the renal pelvis and ureter",
          "UTUC",
          "renal pelvis and ureter TCC",
          "renal pelvis and ureter transitional cell cancer",
          "renal pelvis and ureter transitional cell carcinoma",
          "renal pelvis and ureter urothelial carcinoma",
          "transitional cell cancer of renal pelvis and ureter",
          "transitional cell cancer of the renal pelvis and ureter",
          "transitional cell carcinoma of renal pelvis and ureter",
          "transitional cell carcinoma of the pelvis and ureter",
          "transitional cell carcinoma of the upper urinary tract",
          "upper tract urothelial carcinoma",
          "urothelial carcinoma of the renal pelvis and ureter"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma that arises from the renal pelvis and ureter."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020654"
    },
    {
      "id": 26264,
      "label": "pure squamous carcinoma of the urothelial tract",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6823,
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:695023"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0979280"
    }
  ],
  "roots": [
    {
      "id": 7836,
      "label": "malignant urinary system neoplasm"
    },
    {
      "id": 7972,
      "label": "transitional cell carcinoma"
    },
    {
      "id": 21366,
      "label": "urothelial neoplasm"
    }
  ]
}