{
  "id": 23012,
  "label": "latent tuberculosis infection",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0040753",
  "properties": {
    "xrefs": [
      "GARD:0025831",
      "MEDGEN:294255",
      "MESH:D055985",
      "SCTID:11999007",
      "UMLS:C1609538"
    ],
    "synonyms": [
      "LTBI",
      "inactive TB",
      "inactive tuberculosis",
      "tuberculosis infection latent"
    ],
    "definition": "Mycobacterium tuberculosis infection that does not induce infectious expression of the disease in the affected person, although it can cause continuous immune response generated towards TB antigens; person having LTBI are asymptomatic and acting as a reservoir of active tuberculosis tuberculosis cases and Mycobacterium tuberculosis and run a 5-10% risk of reactivating tuberculosis throughout their lives."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18237,
      "label": "tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2837,
        20027
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:399",
          "GARD:0007827",
          "ICD10CM:A15-A19",
          "ICD10WHO:A15-A19",
          "ICD9:017.90",
          "ICD9:017.92",
          "ICD9:017.94",
          "ICD9:017.96",
          "MEDGEN:22513",
          "MESH:D014376",
          "MedDRA:10044755",
          "NCIT:C3423",
          "NORD:1801",
          "Orphanet:3389",
          "SCTID:56717001",
          "UMLS:C0041296",
          "icd11.foundation:2072728114"
        ],
        "synonyms": [
          "tuberculosis disease",
          "active tuberculosis",
          "Kochs disease",
          "TB"
        ],
        "definition": "A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use."
      },
      "child_count": 24,
      "reference_id": "MONDO:0018076"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18237,
      "label": "tuberculosis"
    }
  ]
}