{
  "id": 23045,
  "label": "drug-resistant tuberculosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0041806",
  "properties": {
    "xrefs": [
      "GARD:0025841",
      "MEDGEN:61616",
      "SCTID:423709000",
      "UMLS:C0206525"
    ],
    "synonyms": [
      "drug resistant tuberculosis"
    ],
    "definition": "Tuberculosis disease caused by Mycobacterium tuberculosis isolate that is resistant to one or more of the antitubercular medications."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 18237,
      "label": "tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2837,
        20027
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:399",
          "GARD:0007827",
          "ICD10CM:A15-A19",
          "ICD10WHO:A15-A19",
          "ICD9:017.90",
          "ICD9:017.92",
          "ICD9:017.94",
          "ICD9:017.96",
          "MEDGEN:22513",
          "MESH:D014376",
          "MedDRA:10044755",
          "NCIT:C3423",
          "NORD:1801",
          "Orphanet:3389",
          "SCTID:56717001",
          "UMLS:C0041296",
          "icd11.foundation:2072728114"
        ],
        "synonyms": [
          "tuberculosis disease",
          "active tuberculosis",
          "Kochs disease",
          "TB"
        ],
        "definition": "A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use."
      },
      "child_count": 24,
      "reference_id": "MONDO:0018076"
    }
  ],
  "children": [
    {
      "id": 7471,
      "label": "multidrug-resistant tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23045
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:401",
          "EFO:0007381",
          "GARD:0024245",
          "MEDGEN:60163",
          "MESH:D018088",
          "NCIT:C128415",
          "SCTID:423092005",
          "UMLS:C0206526"
        ],
        "synonyms": [
          "MDR-TB",
          "multidrug-resistant TB"
        ],
        "definition": "A type of drug-resistant tuberculosis that is resistant to both rifampicin and isoniazid, the two most powerful anti-TB drugs."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005861"
    },
    {
      "id": 24205,
      "label": "rifampicin-resistant tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23045
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026238",
          "MEDGEN:735456",
          "UMLS:C1532782"
        ],
        "synonyms": [
          "RR-TB",
          "rifampicin-resistant TB"
        ],
        "definition": "A form of drug-resistant tuberculosis that is resisant to rifampicin with or without resistance to other antitubercular medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100479"
    },
    {
      "id": 24208,
      "label": "extensively drug-resistant tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23045
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026240",
          "MEDGEN:321809",
          "MESH:D054908",
          "NCIT:C128417",
          "UMLS:C1827301"
        ],
        "synonyms": [
          "XDR-TB"
        ],
        "definition": "A type of drug-resistant tuberculosis that is resistant to any fluoroquinolone, and at least one of three second-line injectable drugs (capreomycin, kanamycin, and amikacin), in addition to resistance to rifampicin and isoniazid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100482"
    },
    {
      "id": 24209,
      "label": "totally drug-resistant tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23045
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026241"
        ],
        "synonyms": [
          "TDR-TB"
        ],
        "definition": "A type of drug-resistant tuberculosis that is resistant to all first- and second-line antitubercular drugs tested (isoniazid, rifampicin, streptomycin, ethambutol, pyrazinamide, ethionamide, para-aminosalicylic acid, cycloserine, ofloxacin, amikacin, ciprofloxacin, capreomycin, kanamycin)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100483"
    }
  ],
  "roots": [
    {
      "id": 18237,
      "label": "tuberculosis"
    }
  ]
}