{
  "id": 23149,
  "label": "panostotic fibrous dysplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0043168",
  "properties": {
    "xrefs": [
      "GARD:0025857",
      "MEDGEN:419799",
      "MESH:C537164",
      "UMLS:C2931430"
    ],
    "synonyms": [
      "unusual facial appearance, bone fragility, hyperphosphatasemia, and hypophosphatemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3155,
      "label": "fibrous dysplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080031",
          "GARD:0006444",
          "ICD9:733.29",
          "MEDGEN:120444",
          "MESH:D005357",
          "MedDRA:10016664",
          "NCIT:C34609",
          "NORD:1147",
          "Orphanet:249",
          "SCTID:10623005",
          "SCTID:254145001",
          "UMLS:C0259779",
          "icd11.foundation:1704766818"
        ],
        "synonyms": [
          "fibrous dysplasia of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A genetic, non-inheritable disorder caused by osteoblastic differentiation defects that result in the replacement of bone marrow and trabecular bone by fibrous stroma and immature bone. It usually affects a single bone and less frequently multiple bones. Skull, femur, tibia, and humerus are the most frequently affected bones. It manifests with pain, deformities, and fractures."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000845"
    },
    {
      "id": 10906,
      "label": "primary myelofibrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16404,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4971",
          "EFO:0002430",
          "GARD:0008618",
          "ICD10CM:D47.4",
          "ICD9:238.76",
          "ICD9:289.83",
          "ICDO:9961/3",
          "MEDGEN:7929",
          "MESH:D055728",
          "NCIT:C2862",
          "NORD:1611",
          "OMIM:254450",
          "ONCOTREE:PMF",
          "Orphanet:824",
          "UMLS:C0001815",
          "icd11.foundation:1407285327",
          "icd11.foundation:336704235"
        ],
        "synonyms": [
          "AMM",
          "Agnogenic myeloid metaplasia",
          "CIMF",
          "chronic idiopathic myelofibrosis",
          "idiopathic bone marrow fibrosis",
          "idiopathic myelofibrosis",
          "myelofibrosis with myeloid metaplasia, somatic",
          "myelofibrosis, somatic",
          "myelosclerosis with myeloid metaplasia",
          "osteomyelofibrosis",
          "primary myelofibrosis",
          "myelofibrosis with myeloid metaplasia",
          "myelofibrosis",
          "myeloid metaplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009692"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3155,
      "label": "fibrous dysplasia"
    },
    {
      "id": 10906,
      "label": "primary myelofibrosis"
    }
  ]
}