{
  "id": 23218,
  "label": "arteritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0043494",
  "properties": {
    "xrefs": [
      "EFO:0009011",
      "HP:0012089",
      "MEDGEN:13916",
      "MESH:D001167",
      "NCIT:C34399",
      "SCTID:52089001",
      "UMLS:C0003860"
    ],
    "synonyms": [
      "arteritis",
      "artery inflammation",
      "inflammation of artery",
      "Arteritides",
      "Inflammation, arterial",
      "arterial Inflammation"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "An inflammatory process affecting an artery."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 2933,
      "label": "arterial disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050828",
          "ICD9:447.8",
          "ICD9:447.9",
          "MEDGEN:208875",
          "NCIT:C35317",
          "SCTID:359557001",
          "UMLS:C0852949"
        ],
        "synonyms": [
          "arterial disease",
          "arterial disorder",
          "arteriopathy",
          "artery disease",
          "artery disease or disorder",
          "disease of artery",
          "disease or disorder of artery",
          "disorder of artery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An impairment of the structure or function of the blood vessels which carry blood away from the heart."
      },
      "child_count": 30,
      "reference_id": "MONDO:0000473"
    },
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    }
  ],
  "children": [
    {
      "id": 3512,
      "label": "cerebral arteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5281,
        12183,
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11390",
          "GARD:0022913",
          "ICD9:437.4",
          "MEDGEN:507535",
          "SCTID:28366008",
          "UMLS:C0007773"
        ],
        "synonyms": [
          "cerebral artery inflammation",
          "inflammation of cerebral artery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An inflammatory disease involving a pathogenic inflammatory response in the cerebral artery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001277"
    },
    {
      "id": 4444,
      "label": "granulomatous angiitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2555",
          "GARD:0023122",
          "MEDGEN:9088",
          "NCIT:C34653",
          "UMLS:C0018202"
        ],
        "synonyms": [
          "Granulomatous arteritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the arteries that is characterized by the presence of granulomas."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002341"
    },
    {
      "id": 17274,
      "label": "juvenile temporal arteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003068",
          "MEDGEN:155583",
          "Orphanet:26137",
          "SCTID:722020006",
          "UMLS:C0751547",
          "icd11.foundation:135739104"
        ],
        "synonyms": [
          "JTA",
          "non-giant cell granulomatous temporal arteritis with eosinophilia",
          "JGCA",
          "JPMR",
          "juvenile cranial arteritis",
          "juvenile giant cell arteritis",
          "juvenile polymyalgia rheumatica"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Juvenile temporal arteritis is a rare form of vasculitis, a group of conditions that cause inflammation of the blood vessels. Unlike the classic form of temporal arteritis, this condition is generally diagnosed in late childhood or early adulthood and only affects the temporal arteries (located at the lower sides of the skull, directly underneath the temple). Affected people often have no signs or symptoms aside from a painless nodule or lump in the temporal region. The exact underlying cause of the condition is unknown. It generally occurs sporadically in people with no family history of the condition. Juvenile temporal arteritis is often treated with surgical excision and rarely recurs."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016848"
    },
    {
      "id": 18167,
      "label": "Takayasu arteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        16127,
        20028,
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2508",
          "EFO:1001857",
          "GARD:0007730",
          "ICD10CM:M31.4",
          "ICD9:446.7",
          "MEDGEN:21458",
          "MESH:D013625",
          "MedDRA:10043097",
          "NANDO:1200251",
          "NANDO:2200423",
          "NCIT:C34391",
          "NCIT:C35062",
          "NORD:806",
          "OMIM:207600",
          "Orphanet:3287",
          "Orphanet:99079",
          "SCTID:239937004",
          "UMLS:C0039263",
          "icd11.foundation:1327645131"
        ],
        "synonyms": [
          "Arteritis, Takayasu",
          "Takayasu arteritis",
          "Takayasu's arteritis",
          "Takayasu's disease",
          "aortic arch arteritis",
          "aortic arch syndrome",
          "cervical aortic arch",
          "idiopathic aortitis",
          "pharyngeal arch artery syndromic disease",
          "TA",
          "Takayasu disease",
          "Young female arteritis",
          "pulseless disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017991"
    },
    {
      "id": 19005,
      "label": "microscopic polyangiitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16324,
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000784",
          "GARD:0003652",
          "ICD10CM:M31.7",
          "MEDGEN:389393",
          "MESH:D055953",
          "MedDRA:10063344",
          "NANDO:1200262",
          "NANDO:2200426",
          "NCIT:C70549",
          "Orphanet:727",
          "SCTID:239928004",
          "UMLS:C2347126",
          "icd11.foundation:999231798"
        ],
        "synonyms": [
          "MPA",
          "Micropolyangiitis",
          "microscopic polyarteritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Microscopic polyangiitis (MPA) is an inflammatory, necrotizing, systemic vasculitis that affects predominantly small vessels (i.e. small arteries, arterioles, capillaries, venules) in multiple organs."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019124"
    },
    {
      "id": 19045,
      "label": "polyarteritis nodosa",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9810",
          "GARD:0007360",
          "ICD10CM:M30.0",
          "ICD9:446.0",
          "MEDGEN:14681",
          "MESH:D010488",
          "MedDRA:10036024",
          "NANDO:1200261",
          "NANDO:2200425",
          "NCIT:C26847",
          "NORD:1588",
          "Orphanet:767",
          "SCTID:155441006",
          "UMLS:C0031036",
          "icd11.foundation:1419332129"
        ],
        "synonyms": [
          "Küssmaul-Maier disease",
          "PAN",
          "classic polyarteritis nodosa",
          "classical polyarteritis nodosa",
          "panarteritis nodosa",
          "periarteritis nodosa",
          "polyarteritis nodosa",
          "periarteritis",
          "polyarteritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019170"
    },
    {
      "id": 23230,
      "label": "endarteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025863",
          "MEDGEN:41777",
          "MESH:D004692",
          "NCIT:C34581",
          "SCTID:33806008",
          "UMLS:C0014100"
        ],
        "synonyms": [
          "endarteritis",
          "inflammation of tunica intima of artery",
          "tunica intima of artery inflammation",
          "Endarteritides"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the arterial intima."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043576"
    }
  ],
  "roots": [
    {
      "id": 2933,
      "label": "arterial disorder"
    },
    {
      "id": 18813,
      "label": "vasculitis"
    }
  ]
}