{
  "id": 23250,
  "label": "serum sickness",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0043789",
  "properties": {
    "xrefs": [
      "MEDGEN:11390",
      "MESH:D012713",
      "NCIT:C79718",
      "SCTID:72284000",
      "UMLS:C0036830",
      "icd11.foundation:715261250"
    ],
    "synonyms": [
      "serum sickness",
      "transfusion reaction due to serum protein reaction",
      "Sicknesses, serum",
      "intoxication by serum",
      "protein sickness",
      "serum Sicknesses",
      "serum reaction",
      "sickness, serum"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4539,
      "label": "type IV hypersensitivity disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2916",
          "MEDGEN:9371",
          "NCIT:C3115",
          "UMLS:C0020522"
        ],
        "synonyms": [
          "DTH",
          "delayed hypersensitivity reaction",
          "delayed-type hypersensitivity",
          "delayed-type hypersensitivity response",
          "disorder of type IV hypersensitivity",
          "type 4 hypersensitivity reaction",
          "type IV hypersensitivity",
          "type IV hypersensitivity reaction",
          "hypersensitivity reaction type IV disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of type IV hypersensitivity."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002459"
    },
    {
      "id": 8426,
      "label": "type III hypersensitivity disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1557",
          "EFO:1001222",
          "MEDGEN:7021",
          "MESH:D007105",
          "MedDRA:10045265",
          "NCIT:C114346",
          "UMLS:C0020951"
        ],
        "synonyms": [
          "disorder of type III hypersensitivity",
          "type 3 hypersensitivity reaction",
          "type III hypersensitivity",
          "type III hypersensitivity reaction",
          "hypersensitivity reaction type III disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa."
      },
      "child_count": 4,
      "reference_id": "MONDO:0007004"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4539,
      "label": "type IV hypersensitivity disease"
    },
    {
      "id": 8426,
      "label": "type III hypersensitivity disease"
    }
  ]
}