{
  "id": 23255,
  "label": "tumor lysis syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0043875",
  "properties": {
    "xrefs": [
      "GARD:0025870",
      "ICD10CM:E88.3",
      "MEDGEN:52890",
      "MESH:D015275",
      "NCIT:C3425",
      "SCTID:277605001",
      "UMLS:C0041364"
    ],
    "synonyms": [
      "tumor lysis syndrome",
      "syndrome, tumor lysis",
      "syndrome, tumour lysis",
      "syndromes, tumor lysis",
      "syndromes, tumour lysis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6795,
      "label": "metabolic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0014667",
          "EFO:0000589",
          "ICD10CM:E70-E88",
          "ICD10WHO:E70-E90",
          "ICD9:277.8",
          "ICD9:277.9",
          "MEDGEN:44376",
          "MESH:D008659",
          "NANDO:1100002",
          "NCIT:C3235",
          "SCTID:75934005",
          "UMLS:C0025517"
        ],
        "synonyms": [
          "disorder of metabolic process",
          "metabolic disease",
          "metabolic disorder",
          "metabolic process disease",
          "disease of metabolism"
        ],
        "definition": "A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process."
      },
      "child_count": 37,
      "reference_id": "MONDO:0005066"
    },
    {
      "id": 20301,
      "label": "neoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        21214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:362147",
          "NCIT:C54705",
          "UMLS:C1882062"
        ],
        "synonyms": [
          "cancer-related syndrome",
          "neoplastic syndrome",
          "tumor syndrome",
          "tumour syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A broad classification for disorders in which the development of neoplasms typically occur in association with a characteristic set of signs or symptoms. These disorders may be inherited or acquired."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021058"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6795,
      "label": "metabolic disease"
    },
    {
      "id": 20301,
      "label": "neoplastic syndrome"
    }
  ]
}