{
  "id": 23338,
  "label": "colorectal signet ring cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044336",
  "properties": {
    "xrefs": [
      "MEDGEN:313040",
      "NCIT:C43586",
      "UMLS:C1707440"
    ],
    "synonyms": [
      "colorectal signet Ring cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        21360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050861",
          "DOID:0050913",
          "EFO:0000365",
          "MEDGEN:230816",
          "NCIT:C5105",
          "ONCOTREE:COADREAD",
          "SCTID:408645001",
          "UMLS:C1319315"
        ],
        "synonyms": [
          "adenocarcinoma of large bowel",
          "adenocarcinoma of large intestine",
          "adenocarcinoma of the large bowel",
          "adenocarcinoma of the large intestine",
          "colorectal (colon or rectal) adenocarcinoma",
          "colorectal adenocarcinoma",
          "colorectum adenocarcinoma",
          "large bowel adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005008"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3493",
          "EFO:0000698",
          "ICDO:8490/3",
          "MEDGEN:61663",
          "MESH:D018279",
          "NCIT:C3774",
          "UMLS:C0206696"
        ],
        "synonyms": [
          "signet ring carcinoma NOS (morphologic abnormality)",
          "signet ring cell adenocarcinoma",
          "signet ring cell carcinoma",
          "signet ring cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005092"
    }
  ],
  "children": [
    {
      "id": 4574,
      "label": "colon signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4386,
        23338
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3033",
          "MEDGEN:313039",
          "NCIT:C7967",
          "UMLS:C1707436"
        ],
        "synonyms": [
          "colon signet Ring cell adenocarcinoma",
          "colonic signet Ring cell adenocarcinoma",
          "signet Ring cell adenocarcinoma of colon",
          "signet Ring cell adenocarcinoma of the colon",
          "signet Ring cell colon adenocarcinoma",
          "colon signet ring adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the colon characterized by the presence of malignant glandular epithelial cells which contain prominent intracytoplasmic mucin (signet ring cells). The signet ring cells constitute more than 50% of the malignant cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002495"
    },
    {
      "id": 6152,
      "label": "rectal signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4295,
        23338
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7707",
          "MEDGEN:124641",
          "NCIT:C9168",
          "UMLS:C0279654"
        ],
        "synonyms": [
          "rectal signet Ring cell adenocarcinoma",
          "rectum signet ring cell carcinoma",
          "signet Ring adenocarcinoma of rectum",
          "signet Ring adenocarcinoma of the rectum",
          "signet Ring cell adenocarcinoma of rectum",
          "signet Ring cell adenocarcinoma of the rectum",
          "rectum signet ring adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma arising from the rectum. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. These cells constitute more than 50% of the malignant cellular population."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004336"
    }
  ],
  "roots": [
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma"
    }
  ]
}