{
  "id": 23388,
  "label": "autoimmune/inflammatory optic neuropathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044685",
  "properties": {
    "xrefs": [
      "GARD:0022037",
      "MEDGEN:1842963",
      "Orphanet:499047",
      "UMLS:C5681239"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7019,
      "label": "eye disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4171,
        21415
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1242",
          "DOID:5614",
          "EFO:0003966",
          "ICD9:360",
          "ICD9:360.29",
          "ICD9:360.89",
          "ICD9:360.9",
          "ICD9:379.8",
          "ICD9:379.90",
          "MEDGEN:5092",
          "MESH:D005128",
          "NCIT:C26767",
          "SCTID:371405004",
          "UMLS:C0015397"
        ],
        "synonyms": [
          "disease of eye",
          "disease of eyeball of camera-type eye",
          "disease or disorder of eyeball of camera-type eye",
          "disorder of eye",
          "disorder of eyeball of camera-type eye",
          "eye disease",
          "eye disorder",
          "eyeball of camera-type eye disease",
          "eyeball of camera-type eye disease or disorder",
          "globe disease",
          "disease of eyeball",
          "disorder of eye proper",
          "disorder of eyeball",
          "disorder of globe"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma."
      },
      "child_count": 240,
      "reference_id": "MONDO:0005328"
    }
  ],
  "children": [
    {
      "id": 18986,
      "label": "neuromyelitis optica",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        23388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8869",
          "EFO:0004256",
          "GARD:0006267",
          "ICD10CM:G36.0",
          "ICD9:341.0",
          "MEDGEN:45063",
          "MESH:D009471",
          "MedDRA:10029322",
          "NANDO:1200027",
          "NANDO:2201322",
          "NCIT:C84934",
          "NORD:1505",
          "Orphanet:71211",
          "SCTID:25044007",
          "UMLS:C0027873",
          "icd11.foundation:744293382"
        ],
        "synonyms": [
          "Devic disease",
          "Neuromyelitis Optica Spectrum Disorder",
          "Devic syndrome",
          "Devic's neuromyelitis optica",
          "NMO"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare inflammatory disease of the central nervous system characterized mainly by attacks of uni- or bilateral optic neuritis (ON) and acute myelitis."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019100"
    },
    {
      "id": 23389,
      "label": "chronic relapsing inflammatory optic neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022038",
          "MEDGEN:1798657",
          "Orphanet:499085",
          "UMLS:C5567234"
        ],
        "synonyms": [
          "CRION",
          "chronic recurrent isolated optic neuritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare inflammatory optic neuropathy characterized by severe and persistent pain followed by subacute visual loss, a relapsing-remitting course, and steroid-dependence. Involvement of both optic nerves is common and is usually sequential. Serum antibodies against aquaporin 4 are absent in most cases. Magnetic resonance imaging shows contrast enhancement of the acutely inflamed optic nerves."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044687"
    },
    {
      "id": 23390,
      "label": "isolated optic neuritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022039",
          "MEDGEN:1864429",
          "Orphanet:499096",
          "UMLS:C5848152"
        ],
        "synonyms": [
          "ION",
          "ion"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare inflammatory optic neuropathy characterized by isolated episodes (either single or recurrent) of optic neuritis not associated with other neurological or systemic disease. Patients typically present with subacute unilateral loss of vision progressing over several days to two weeks, periocular pain and pain on eye movement (which may precede the onset of visual symptoms), light flashes on eye movement, abnormal color vision, reduced contrast sensitivity, and relative afferent pupillary defect. The optic disk appears swollen in many patients, and uveitis may be associated and can be present for years before the onset of optic neuritis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044688"
    },
    {
      "id": 23391,
      "label": "recurrent idiopathic neuroretinitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23388,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022040",
          "MEDGEN:1814450",
          "Orphanet:499103",
          "UMLS:C5680094"
        ],
        "synonyms": [
          "RINR"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare inflammatory optic neuropathy characterized by recurrent episodes of idiopathic inflammation of the optic nerve head with optic disk edema associated with macular exudate in a star-shaped pattern. Patients present with acute visual loss, most typically in the form of a large central scotoma. Pain is mild or absent. Bilateral involvement is frequent and usually sequential. The interval between attacks is highly variable, ranging from months to several years. Visual loss is cumulative with each attack and often severe."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044689"
    },
    {
      "id": 23392,
      "label": "optic perineuritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022041",
          "MEDGEN:881493",
          "Orphanet:499107",
          "SCTID:713417000",
          "UMLS:C4076165",
          "icd11.foundation:349248275"
        ],
        "synonyms": [
          "OPN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare ophthalmic disorder characterized by idiopathic orbital inflammation in which the specific target tissue is the optic nerve sheath. Patients typically present with ocular pain, pain on eye movement, visual symptoms with loss of vision progressing over several weeks, dyschromatopsia, and variable visual field defects. Orbital signs and symptoms may be present and include ptosis, ophthalmoplegia, and exophthalmos. Optic disk edema is observed in most cases. The condition is usually unilateral."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044690"
    }
  ],
  "roots": [
    {
      "id": 7019,
      "label": "eye disorder"
    }
  ]
}