{
  "id": 23390,
  "label": "isolated optic neuritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044688",
  "properties": {
    "xrefs": [
      "GARD:0022039",
      "MEDGEN:1864429",
      "Orphanet:499096",
      "UMLS:C5848152"
    ],
    "synonyms": [
      "ION",
      "ion"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A rare inflammatory optic neuropathy characterized by isolated episodes (either single or recurrent) of optic neuritis not associated with other neurological or systemic disease. Patients typically present with subacute unilateral loss of vision progressing over several days to two weeks, periocular pain and pain on eye movement (which may precede the onset of visual symptoms), light flashes on eye movement, abnormal color vision, reduced contrast sensitivity, and relative afferent pupillary defect. The optic disk appears swollen in many patients, and uveitis may be associated and can be present for years before the onset of optic neuritis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 23388,
      "label": "autoimmune/inflammatory optic neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7019
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022037",
          "MEDGEN:1842963",
          "Orphanet:499047",
          "UMLS:C5681239"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0044685"
    }
  ],
  "children": [
    {
      "id": 22886,
      "label": "isolated optic neuritis without anti-MOG antibodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23390
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022376",
          "Orphanet:592885"
        ],
        "synonyms": [
          "Isolated optic neuritis without anti-myelin oligodendrocyte glycoprotein antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035667"
    },
    {
      "id": 22887,
      "label": "isolated optic neuritis with anti-MOG antibodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23390,
        29255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022377",
          "Orphanet:592888"
        ],
        "synonyms": [
          "Isolated optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035668"
    },
    {
      "id": 26022,
      "label": "single isolated optic neuritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23390
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027160",
          "MEDGEN:1863952",
          "Orphanet:659626",
          "UMLS:C5925137"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971049"
    },
    {
      "id": 26023,
      "label": "relapsing isolated optic neuritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23390
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027161",
          "MEDGEN:1863611",
          "Orphanet:659634",
          "UMLS:C5925139"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971050"
    }
  ],
  "roots": [
    {
      "id": 23388,
      "label": "autoimmune/inflammatory optic neuropathy"
    }
  ]
}