{
  "id": 23401,
  "label": "lip and oral cavity squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044710",
  "properties": {
    "xrefs": [
      "GARD:0022046",
      "MEDGEN:124714",
      "NCIT:C42690",
      "Orphanet:502369",
      "UMLS:C0280297"
    ],
    "synonyms": [
      "lip and oral cavity squamous cell cancer",
      "lip and oral cavity squamous cell carcinoma",
      "lip/oral cavity squam. cell car.",
      "squamous cell carcinoma of oral cavity and lip"
    ],
    "categories": [
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 11332,
      "label": "head and neck squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4185,
        6823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5520",
          "EFO:0000181",
          "GARD:0008503",
          "MEDGEN:257911",
          "MESH:C535575",
          "MedDRA:10060121",
          "NCIT:C34447",
          "OMIM:275355",
          "ONCOTREE:HNSC",
          "Orphanet:67037",
          "SCTID:716659002",
          "UMLS:C1168401"
        ],
        "synonyms": [
          "HNSCC",
          "SCCHN",
          "craniocervical region squamous cell carcinoma",
          "head and neck squamous cell carcinoma",
          "squamous cell carcinoma of head and neck",
          "squamous cell carcinoma of the head and neck",
          "squamous cell carcinoma, head and neck, somatic",
          "carcinoma of the head and neck",
          "squamous cell carcinoma, head and neck"
        ],
        "definition": "A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands."
      },
      "child_count": 26,
      "reference_id": "MONDO:0010150"
    },
    {
      "id": 21254,
      "label": "lip and oral cavity carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4185
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009342",
          "MEDGEN:67387",
          "NCIT:C9315",
          "UMLS:C0220641"
        ],
        "synonyms": [
          "lip and oral cavity cancer",
          "lip and oral cavity carcinoma",
          "oral cancer",
          "oral carcinoma"
        ],
        "definition": "A carcinoma arising in the lip or oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. Lip carcinomas are usually basal cell or squamous cell carcinomas."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023644"
    },
    {
      "id": 21538,
      "label": "otorhinolaryngologic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:478.19",
          "MEDGEN:583054",
          "MESH:D010038",
          "NANDO:1100015",
          "NCIT:C118420",
          "SCTID:232208008",
          "UMLS:C0395797"
        ],
        "synonyms": [
          "ear, nose and throat disorder",
          "ear, nose or throat disorder",
          "ear/nose/throat disease",
          "otolaryngologic disorder",
          "otorhinolaryngologic disease",
          "ENT disease",
          "ENT diseases",
          "disease, ENT",
          "disease, otolaryngologic",
          "disease, otolaryngological",
          "disease, otorhinolaryngologic",
          "disease, otorhinolaryngological",
          "diseases, ENT",
          "diseases, otolaryngologic",
          "diseases, otolaryngological",
          "diseases, otorhinolaryngologic",
          "diseases, otorhinolaryngological",
          "otolaryngologic disease",
          "otolaryngologic diseases",
          "otolaryngological disease",
          "otolaryngological diseases",
          "otorhinolaryngological disease",
          "otorhinolaryngological diseases"
        ],
        "categories": [
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases."
      },
      "child_count": 40,
      "reference_id": "MONDO:0024623"
    }
  ],
  "children": [
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23401,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050866",
          "EFO:0000199",
          "GARD:0017932",
          "MEDGEN:108436",
          "NCIT:C4833",
          "ONCOTREE:OCSC",
          "Orphanet:502363",
          "SCTID:307502000",
          "UMLS:C0585362"
        ],
        "synonyms": [
          "mouth scc",
          "mouth squamous cell carcinoma",
          "oral cavity scc",
          "oral cavity squamous cell cancer",
          "oral cavity squamous cell carcinoma",
          "scc of mouth",
          "scc of oral cavity",
          "scc of the mouth",
          "scc of the oral cavity",
          "squamous cell carcinoma of mouth",
          "squamous cell carcinoma of oral cavity",
          "squamous cell carcinoma of the mouth",
          "squamous cell carcinoma of the oral cavity",
          "OCSC",
          "oral squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status."
      },
      "child_count": 14,
      "reference_id": "MONDO:0004958"
    }
  ],
  "roots": [
    {
      "id": 11332,
      "label": "head and neck squamous cell carcinoma"
    },
    {
      "id": 21254,
      "label": "lip and oral cavity carcinoma"
    },
    {
      "id": 21538,
      "label": "otorhinolaryngologic disease"
    }
  ]
}