{
  "id": 23416,
  "label": "salivary gland squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044740",
  "properties": {
    "xrefs": [
      "EFO:1001967",
      "GARD:0017929",
      "MEDGEN:83545",
      "NCIT:C7991",
      "Orphanet:500481",
      "UMLS:C0279697"
    ],
    "synonyms": [
      "SCC of salivary gland",
      "SCC of the salivary gland",
      "epidermoid carcinoma of salivary gland",
      "epidermoid carcinoma of the salivary gland",
      "saliva-secreting gland squamous cell carcinoma",
      "salivary gland SCC",
      "salivary gland epidermoid carcinoma",
      "salivary gland squamous cell cancer",
      "salivary gland squamous cell carcinoma",
      "squamous cell carcinoma of salivary gland",
      "squamous cell carcinoma of the salivary gland",
      "squamous cell carcinoma of salivary glands"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the salivary glands. The majority of patients are in their sixth through eight decades. It usually presents as a rapidly enlarging mass, which may be painful. It usually has an aggressive clinical course."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6453,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050904",
          "GARD:0027535",
          "MEDGEN:215302",
          "NANDO:2200076",
          "NCIT:C9272",
          "ONCOTREE:SACA",
          "UMLS:C0948750"
        ],
        "synonyms": [
          "salivary gland cancer",
          "carcinoma of saliva-secreting gland",
          "carcinoma of salivary gland",
          "carcinoma of the salivary gland",
          "saliva-secreting gland carcinoma",
          "salivary gland carcinoma",
          "salivary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000521"
    },
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23401,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050866",
          "EFO:0000199",
          "GARD:0017932",
          "MEDGEN:108436",
          "NCIT:C4833",
          "ONCOTREE:OCSC",
          "Orphanet:502363",
          "SCTID:307502000",
          "UMLS:C0585362"
        ],
        "synonyms": [
          "mouth scc",
          "mouth squamous cell carcinoma",
          "oral cavity scc",
          "oral cavity squamous cell cancer",
          "oral cavity squamous cell carcinoma",
          "scc of mouth",
          "scc of oral cavity",
          "scc of the mouth",
          "scc of the oral cavity",
          "squamous cell carcinoma of mouth",
          "squamous cell carcinoma of oral cavity",
          "squamous cell carcinoma of the mouth",
          "squamous cell carcinoma of the oral cavity",
          "OCSC",
          "oral squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status."
      },
      "child_count": 14,
      "reference_id": "MONDO:0004958"
    },
    {
      "id": 17510,
      "label": "malignant epithelial tumor of salivary glands",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7231,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021043",
          "MEDGEN:1674486",
          "Orphanet:276145",
          "UMLS:C5190832"
        ],
        "synonyms": [
          "malignant epithelial tumor of the salivary glands",
          "malignant epithelial tumour of the salivary glands"
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0017167"
    }
  ],
  "children": [
    {
      "id": 7884,
      "label": "parotid gland squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20508,
        23416
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000463",
          "GARD:0024382",
          "MEDGEN:233317",
          "NCIT:C5942",
          "UMLS:C1335367",
          "icd11.foundation:552798341"
        ],
        "synonyms": [
          "parotid gland squamous cell carcinoma",
          "parotid squamous cell carcinoma",
          "squamous cell carcinoma of parotid",
          "squamous cell carcinoma of parotid gland",
          "squamous cell carcinoma of the parotid",
          "squamous cell carcinoma of the parotid gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "An invasive squamous cell carcinoma that arises from the parotid gland. It usually affects elderly patients and presents as a rapidly enlarging tumor mass, often associated with pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006358"
    },
    {
      "id": 7920,
      "label": "salivary gland adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        23416
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024398",
          "MEDGEN:277627",
          "NCIT:C35737",
          "UMLS:C1335894"
        ],
        "synonyms": [
          "saliva-secreting gland adenosquamous carcinoma",
          "salivary gland adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare, aggressive carcinoma that arises from the salivary glands. It is characterized by the presence of a squamous and a glandular epithelial component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006401"
    }
  ],
  "roots": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma"
    },
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma"
    },
    {
      "id": 17510,
      "label": "malignant epithelial tumor of salivary glands"
    }
  ]
}