{
  "id": 23461,
  "label": "refractory cytopenia of childhood",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044874",
  "properties": {
    "xrefs": [
      "GARD:0025914",
      "MEDGEN:417430",
      "NCIT:C82596",
      "ONCOTREE:RCYC",
      "UMLS:C2826323",
      "icd11.foundation:699075426"
    ],
    "synonyms": [
      "RCC",
      "refractory cytopenia of childhood"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "The most common subtype of the myelodysplastic syndromes affecting children. It is characterized by persistent cytopenia with less than 5% blasts in the bone marrow and less than 2% blasts in the peripheral blood."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5945,
      "label": "refractory hematologic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:712",
          "GARD:0023831",
          "MEDGEN:233400",
          "NCIT:C27357",
          "UMLS:C1335724"
        ],
        "synonyms": [
          "refractory hematologic cancer",
          "refractory hematologic malignancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hematologic malignancy that is resistant to treatment."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004111"
    },
    {
      "id": 23460,
      "label": "childhood myelodysplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18812
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025913",
          "MEDGEN:389541",
          "NANDO:2100003",
          "NANDO:2200019",
          "NCIT:C68744",
          "UMLS:C2347761"
        ],
        "synonyms": [
          "myelodysplastic syndrome",
          "childhood MDS",
          "childhood myelodysplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An uncommon hematologic malignancy occurring during childhood. Many of the morphologic, immunophenotypic, and genetic changes seen in adult myelodysplastic syndromes are also observed in the childhood variants of the disease. Children present with neutropenia and thrombocytopenia more often than adults, and bone marrow hypocellularity is more often seen in children than adults."
      },
      "child_count": 1,
      "reference_id": "MONDO:0044873"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5945,
      "label": "refractory hematologic cancer"
    },
    {
      "id": 23460,
      "label": "childhood myelodysplastic syndrome"
    }
  ]
}