{
  "id": 23467,
  "label": "hematopoietic and lymphoid cell neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044881",
  "properties": {
    "xrefs": [
      "GARD:0025916",
      "MEDGEN:91264",
      "NCIT:C27134",
      "UMLS:C0376544"
    ],
    "synonyms": [
      "HEMOLYMPHORETICULAR tumor, malignant",
      "haematological neoplasm",
      "haematological tumour",
      "haematopoietic and lymphoid neoplasms",
      "haematopoietic cancer",
      "haematopoietic cell tumour",
      "haematopoietic malignancy, NOS",
      "haematopoietic neoplasm",
      "haematopoietic neoplasms including lymphomas",
      "haematopoietic tumour",
      "hematologic cancer",
      "hematologic malignancy",
      "hematologic neoplasm",
      "hematological neoplasm",
      "hematological tumor",
      "hematopoietic and lymphoid cell neoplasm",
      "hematopoietic and lymphoid neoplasms",
      "hematopoietic cancer",
      "hematopoietic cell tumor",
      "hematopoietic malignancy, NOS",
      "hematopoietic neoplasm",
      "hematopoietic neoplasms including lymphomas",
      "hematopoietic tumor",
      "hematopoietic, Including myeloma",
      "malignant haematopoietic neoplasm",
      "malignant hematologic neoplasm",
      "malignant hematopoietic neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4440,
      "label": "hematopoietic and lymphoid system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2531",
          "GARD:0023120",
          "MEDGEN:268180",
          "MESH:D019337",
          "NCIT:C35813",
          "SCTID:129154003",
          "UMLS:C1512393"
        ],
        "synonyms": [
          "haematopoietic neoplasm",
          "haematopoietic neoplasm (morphologic abnormality)",
          "hematologic neoplasm",
          "hematopoietic neoplasm",
          "hematopoietic neoplasm (morphologic abnormality)",
          "blood neoplasm (disease)",
          "blood tumor",
          "blood tumour",
          "haematological tumours",
          "haematopoietic and lymphoid system tumour",
          "haematopoietic system neoplasm",
          "haematopoietic system tumour",
          "haematopoietic tumours",
          "hematopoietic and lymphoid system neoplasm",
          "hematopoietic and lymphoid system tumor",
          "hematopoietic system neoplasm",
          "hematopoietic system tumor",
          "neoplasm of blood",
          "neoplasm of haematopoietic system",
          "neoplasm of hematopoietic system",
          "tumor of blood",
          "tumor of hematopoietic system",
          "tumour of blood",
          "tumour of haematopoietic system",
          "blood cancer",
          "haematopoietic cancer",
          "hematologic malignancy",
          "hematopoietic cancer",
          "malignant haematopoietic neoplasm (morphologic abnormality)",
          "malignant hematopoietic neoplasm (morphologic abnormality)",
          "hematologic cancer",
          "malignant haematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003"
      },
      "child_count": 18,
      "reference_id": "MONDO:0002334"
    }
  ],
  "children": [
    {
      "id": 5530,
      "label": "central nervous system hematopoietic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7694,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5772",
          "GARD:0023597",
          "MEDGEN:234101",
          "NCIT:C5503",
          "UMLS:C1332882"
        ],
        "synonyms": [
          "CNS haematopoietic neoplasm",
          "CNS haematopoietic tumour",
          "CNS hematopoietic neoplasm",
          "CNS hematopoietic tumor",
          "central nervous system haematopoietic and lymphoid system neoplasm",
          "central nervous system haematopoietic neoplasms",
          "central nervous system haematopoietic tumour",
          "central nervous system hematopoietic and lymphoid system neoplasm",
          "central nervous system hematopoietic neoplasm",
          "central nervous system hematopoietic neoplasms",
          "central nervous system hematopoietic tumor",
          "haematopoietic and lymphoid system neoplasm of central nervous system",
          "haematopoietic neoplasm of CNS",
          "haematopoietic neoplasm of central nervous system",
          "haematopoietic neoplasm of the CNS",
          "haematopoietic neoplasm of the central nervous system",
          "haematopoietic tumour of central nervous system",
          "haematopoietic tumour of the central nervous system",
          "hematopoietic and lymphoid system neoplasm of central nervous system",
          "hematopoietic neoplasm of CNS",
          "hematopoietic neoplasm of central nervous system",
          "hematopoietic neoplasm of the CNS",
          "hematopoietic neoplasm of the central nervous system",
          "hematopoietic tumor of central nervous system",
          "hematopoietic tumor of the central nervous system",
          "lymphomas and hemopoietic neoplasms of CNS",
          "lymphomas and hemopoietic neoplasms of the CNS",
          "central nervous system hematologic cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A primary or metastatic neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. Representative examples include Hodgkin and non-Hodgkin lymphomas, histiocytic tumors, and leukemias."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003641"
    },
    {
      "id": 5945,
      "label": "refractory hematologic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:712",
          "GARD:0023831",
          "MEDGEN:233400",
          "NCIT:C27357",
          "UMLS:C1335724"
        ],
        "synonyms": [
          "refractory hematologic cancer",
          "refractory hematologic malignancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hematologic malignancy that is resistant to treatment."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004111"
    },
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    },
    {
      "id": 6881,
      "label": "lymphoid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001642",
          "GARD:0024157",
          "ICD9:200.7",
          "MEDGEN:108626",
          "NCIT:C7065",
          "ONCOTREE:LYMPH",
          "UMLS:C0598798"
        ],
        "synonyms": [
          "lymphocytic and plasma cell neoplasm",
          "lymphocytic and plasma cell tumor",
          "lymphocytic and plasma cell tumour",
          "lymphocytic and plasmacytic neoplasm",
          "lymphocytic neoplasm",
          "lymphocytic tumor",
          "lymphocytic tumour",
          "lymphoid and plasma cell tumor",
          "lymphoid and plasma cell tumour",
          "lymphoid and plasmacytic neoplasm",
          "lymphoid and plasmacytic tumor",
          "lymphoid and plasmacytic tumour",
          "lymphoid neoplasm",
          "lymphoid tumor",
          "lymphoid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005157"
    },
    {
      "id": 6892,
      "label": "myeloid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070004",
          "EFO:0002427",
          "GARD:0024160",
          "ICDO:9975/1",
          "MEDGEN:445430",
          "NCIT:C9290",
          "ONCOTREE:MYELOID",
          "UMLS:C2939461"
        ],
        "synonyms": [
          "myeloid malignancy",
          "myeloid neoplasm",
          "myeloid tumor",
          "myeloid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Proliferation of myeloid cells originating from a primitive stem cell."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005170"
    },
    {
      "id": 7797,
      "label": "histiocytic and dendritic cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16514,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5621",
          "EFO:1000297",
          "GARD:0019441",
          "MEDGEN:714988",
          "NCIT:C9294",
          "Orphanet:98287",
          "UMLS:C1292762"
        ],
        "synonyms": [
          "histiocytic and Dendritic cell neoplasms",
          "histiocytic and Dendritic cell tumors",
          "histiocytic and Dendritic cell tumours",
          "histiocytic and dendritic cell neoplasm",
          "histiocytic and dendritic cell",
          "histiocytic and dendritic cell cancer",
          "histiocytic and dendritic cell tumor",
          "histiocytic and dendritic cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. They can occur at any age and show no significant variations in geographical distribution. This category includes the histiocytic sarcoma, Langerhans cell histiocytosis, Langerhans cell sarcoma, interdigitading dendritic cell sarcoma/tumor, follicular dendritic cell sarcoma/tumor, and dendritic cell sarcoma, not otherwise specified. (WHO, 2001)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0006247"
    },
    {
      "id": 16453,
      "label": "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080164",
          "GARD:0020105",
          "MEDGEN:417664",
          "NCIT:C84270",
          "Orphanet:168943",
          "UMLS:C2827356"
        ],
        "synonyms": [
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2",
          "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
          "myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement",
          "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0015688"
    },
    {
      "id": 19280,
      "label": "myelodysplastic syndrome with excess blasts",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18812,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003811",
          "GARD:0019070",
          "ICDO:9983/3",
          "MEDGEN:8066",
          "MESH:D000754",
          "MedDRA:10038270",
          "NCIT:C7506",
          "Orphanet:86839",
          "SCTID:398623004",
          "UMLS:C0002894"
        ],
        "synonyms": [
          "MDS-EB",
          "RAEB",
          "myelodysplastic syndrome with Excess blasts",
          "refractory Anaemia with Excess blasts",
          "refractory Anaemia with an Excess of blasts",
          "refractory Anemia with Excess blasts",
          "refractory Anemia with an Excess of blasts"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It includes two categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic syndrome with excess blasts-2."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019454"
    }
  ],
  "roots": [
    {
      "id": 4440,
      "label": "hematopoietic and lymphoid system neoplasm"
    }
  ]
}