{
  "id": 23483,
  "label": "oral cavity carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044925",
  "properties": {
    "xrefs": [
      "GARD:0027982",
      "MEDGEN:57468",
      "NCIT:C8990",
      "UMLS:C0151546"
    ],
    "synonyms": [
      "oral cavity cancer",
      "carcinoma of mouth",
      "carcinoma of oral cavity",
      "carcinoma of the oral cavity",
      "mouth carcinoma",
      "oral cavity carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 7170,
      "label": "oral cavity cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        20454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8618",
          "EFO:0005570",
          "ICD9:144",
          "ICD9:144.0",
          "ICD9:144.1",
          "ICD9:145.8",
          "ICD9:145.9",
          "ICD9:149.8",
          "MEDGEN:56298",
          "NCIT:C9314",
          "SCTID:363505006",
          "UMLS:C0153381"
        ],
        "synonyms": [
          "cancer of oral cavity",
          "malignant mouth neoplasm",
          "malignant mouth tumor",
          "malignant mouth tumour",
          "malignant neoplasm of mouth",
          "malignant neoplasm of oral cavity",
          "malignant neoplasm of the mouth",
          "malignant oral cavity neoplasm",
          "malignant oral cavity tumor",
          "malignant oral cavity tumour",
          "malignant tumor of anterior floor of mouth",
          "malignant tumor of lateral floor of mouth",
          "malignant tumor of mouth",
          "malignant tumor of oral cavity",
          "malignant tumor of the mouth",
          "malignant tumour of anterior floor of mouth",
          "malignant tumour of lateral floor of mouth",
          "malignant tumour of mouth",
          "malignant tumour of oral cavity",
          "malignant tumour of the mouth",
          "oral cavity cancer",
          "malignant neoplasm of anterior portion of floor of mouth",
          "malignant neoplasm of floor of mouth",
          "malignant neoplasm of lateral floor of mouth",
          "malignant neoplasm of lateral portion of floor of mouth",
          "malignant tumor of the floor of the mouth",
          "malignant tumour of the floor of the mouth",
          "mouth cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005515"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    },
    {
      "id": 21254,
      "label": "lip and oral cavity carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4185
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009342",
          "MEDGEN:67387",
          "NCIT:C9315",
          "UMLS:C0220641"
        ],
        "synonyms": [
          "lip and oral cavity cancer",
          "lip and oral cavity carcinoma",
          "oral cancer",
          "oral carcinoma"
        ],
        "definition": "A carcinoma arising in the lip or oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. Lip carcinomas are usually basal cell or squamous cell carcinomas."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023644"
    }
  ],
  "children": [
    {
      "id": 2870,
      "label": "oral cavity carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050610",
          "GARD:0027525",
          "MEDGEN:138076",
          "NCIT:C4587",
          "SCTID:92660005",
          "UMLS:C0347073",
          "icd11.foundation:1389868484"
        ],
        "synonyms": [
          "carcinoma in situ of mouth",
          "carcinoma in situ of oral cavity",
          "carcinoma in situ of the mouth",
          "carcinoma in situ of the oral cavity",
          "mouth carcinoma in situ",
          "oral cavity in situ carcinoma",
          "stage 0 carcinoma of mouth",
          "stage 0 carcinoma of oral cavity",
          "stage 0 carcinoma of the mouth",
          "stage 0 carcinoma of the oral cavity",
          "stage 0 mouth carcinoma",
          "stage 0 oral cavity cancer",
          "stage 0 oral cavity cancer aJCC v6",
          "stage 0 oral cavity cancer aJCC v6 and v7",
          "stage 0 oral cavity cancer aJCC v7",
          "stage 0 oral cavity carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the oral cavity."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000371"
    },
    {
      "id": 2972,
      "label": "salivary gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6453,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050904",
          "GARD:0027535",
          "MEDGEN:215302",
          "NANDO:2200076",
          "NCIT:C9272",
          "ONCOTREE:SACA",
          "UMLS:C0948750"
        ],
        "synonyms": [
          "salivary gland cancer",
          "carcinoma of saliva-secreting gland",
          "carcinoma of salivary gland",
          "carcinoma of the salivary gland",
          "saliva-secreting gland carcinoma",
          "salivary gland carcinoma",
          "salivary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000521"
    },
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23401,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050866",
          "EFO:0000199",
          "GARD:0017932",
          "MEDGEN:108436",
          "NCIT:C4833",
          "ONCOTREE:OCSC",
          "Orphanet:502363",
          "SCTID:307502000",
          "UMLS:C0585362"
        ],
        "synonyms": [
          "mouth scc",
          "mouth squamous cell carcinoma",
          "oral cavity scc",
          "oral cavity squamous cell cancer",
          "oral cavity squamous cell carcinoma",
          "scc of mouth",
          "scc of oral cavity",
          "scc of the mouth",
          "scc of the oral cavity",
          "squamous cell carcinoma of mouth",
          "squamous cell carcinoma of oral cavity",
          "squamous cell carcinoma of the mouth",
          "squamous cell carcinoma of the oral cavity",
          "OCSC",
          "oral squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status."
      },
      "child_count": 14,
      "reference_id": "MONDO:0004958"
    },
    {
      "id": 20507,
      "label": "carcinoma of soft palate",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6400,
        23483,
        23484
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027892",
          "MEDGEN:87505",
          "NCIT:C8395",
          "SCTID:254435009",
          "UMLS:C0345555"
        ],
        "synonyms": [
          "soft palate cancer",
          "carcinoma of soft palate",
          "carcinoma of the soft palate",
          "soft palate carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A carcinoma that arises from the soft palate. The majority are squamous cell carcinomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021329"
    },
    {
      "id": 20509,
      "label": "carcinoma of lip",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8278,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027894",
          "MEDGEN:56195",
          "NCIT:C3490",
          "SCTID:269515006",
          "UMLS:C0149637"
        ],
        "synonyms": [
          "lip cancer",
          "carcinoma of lip",
          "carcinoma of the Lip",
          "lip carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that involves the lip."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021333"
    },
    {
      "id": 20513,
      "label": "carcinoma of hard palate",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6497,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027896",
          "MEDGEN:138019",
          "NCIT:C8394",
          "SCTID:254434008",
          "UMLS:C0345550"
        ],
        "synonyms": [
          "carcinoma of hard palate",
          "carcinoma of the hard palate",
          "hard palate carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that involves the hard palate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021339"
    },
    {
      "id": 23487,
      "label": "oral cavity mucoepidermoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5029,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025926",
          "MEDGEN:83629",
          "NCIT:C8177",
          "UMLS:C0280309"
        ],
        "synonyms": [
          "mucoepidermoid carcinoma of oral cavity",
          "mucoepidermoid carcinoma of the oral cavity",
          "oral cavity mucoepidermoid cancer",
          "oral cavity mucoepidermoid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A mucoepidermoid carcinoma arising from the minor salivary glands in the oral cavity. It is often asymptomatic and detected during a routine dental examination."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044964"
    },
    {
      "id": 25164,
      "label": "tongue carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6418,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080641",
          "GARD:0028068",
          "MEDGEN:154320",
          "NCIT:C4824",
          "UMLS:C0558353"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850154"
    },
    {
      "id": 26050,
      "label": "intraoral basal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027181",
          "MEDGEN:1864187",
          "Orphanet:667678",
          "UMLS:C5925085"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971111"
    }
  ],
  "roots": [
    {
      "id": 7170,
      "label": "oral cavity cancer"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    },
    {
      "id": 21254,
      "label": "lip and oral cavity carcinoma"
    }
  ]
}