{
  "id": 23485,
  "label": "rectal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044937",
  "properties": {
    "xrefs": [
      "MEDGEN:40100",
      "NCIT:C9382",
      "UMLS:C0007113"
    ],
    "synonyms": [
      "cancer of rectum",
      "cancer of the rectum",
      "rectal cancer",
      "carcinoma of rectum",
      "carcinoma of the rectum",
      "rectal carcinoma",
      "rectum carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 8006,
      "label": "rectal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4291,
        7221
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1993",
          "EFO:1000657",
          "ICD10CM:C20",
          "ICD9:154.1",
          "MEDGEN:181763",
          "NCIT:C7418",
          "SCTID:363351006",
          "UMLS:C0949022",
          "icd11.foundation:1113099195"
        ],
        "synonyms": [
          "carcinoma of rectum",
          "carcinoma of the rectum",
          "cancer of rectum",
          "malignant neoplasm of rectum",
          "malignant neoplasm of the rectum",
          "malignant rectal neoplasm",
          "malignant rectal tumor",
          "malignant rectal tumour",
          "malignant rectum neoplasm",
          "malignant rectum tumour",
          "malignant tumor of rectum",
          "malignant tumor of the rectum",
          "malignant tumour of rectum",
          "malignant tumour of the rectum",
          "rectal cancer",
          "rectum cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006519"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7221,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080199",
          "EFO:1001951",
          "MEDGEN:3170",
          "NCIT:C2955",
          "UMLS:C0009402"
        ],
        "synonyms": [
          "cancer of large bowel",
          "cancer of large intestine",
          "cancer of the large bowel",
          "cancer of the large intestine",
          "colorectal (colon or rectal) cancer",
          "colorectal cancer",
          "large bowel cancer",
          "large intestine cancer",
          "CRC",
          "carcinoma of colorectum",
          "carcinoma of large bowel",
          "carcinoma of large intestine",
          "carcinoma of the large bowel",
          "carcinoma of the large intestine",
          "colorectal carcinoma",
          "colorectum carcinoma",
          "large bowel carcinoma",
          "large intestine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024331"
    },
    {
      "id": 21431,
      "label": "epithelial neoplasm of rectum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4291,
        7265
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "rectal epithelial neoplasm",
          "rectal epithelial tumor",
          "rectal epithelial tumour",
          "rectum epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A epithelial neoplasm that involves the rectum."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024476"
    }
  ],
  "children": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1996",
          "EFO:0005631",
          "MEDGEN:56214",
          "NCIT:C9383",
          "ONCOTREE:READ",
          "SCTID:254582000",
          "UMLS:C0149978",
          "icd11.foundation:1316028436"
        ],
        "synonyms": [
          "adenocarcinoma - rectum",
          "adenocarcinoma of rectum",
          "adenocarcinoma of the rectum",
          "rectal adenocarcinoma",
          "rectum adenocarcinoma",
          "read"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002169"
    },
    {
      "id": 4512,
      "label": "rectosigmoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4179,
        4513,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2781",
          "MEDGEN:232963",
          "NCIT:C7421",
          "UMLS:C1327709",
          "icd11.foundation:1415734886"
        ],
        "synonyms": [
          "carcinoma of rectosigmoid junction",
          "rectosigmoid cancer",
          "rectosigmoid carcinoma",
          "rectosigmoid junction carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the rectosigmoid area and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. About 50% of colorectal carcinomas occur in the rectosigmoid area."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002424"
    },
    {
      "id": 5158,
      "label": "anal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4054,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4908",
          "GARD:0027634",
          "MEDGEN:76006",
          "NCIT:C9291",
          "SCTID:448315008",
          "UMLS:C0279637"
        ],
        "synonyms": [
          "Ca anus",
          "anal cancer",
          "cancer of anus",
          "cancer of the anus",
          "anal carcinoma",
          "anus carcinoma",
          "carcinoma of anus",
          "carcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anus"
      },
      "child_count": 8,
      "reference_id": "MONDO:0003199"
    },
    {
      "id": 6018,
      "label": "rectal sarcomatoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7925,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7356",
          "MEDGEN:235533",
          "NCIT:C5556",
          "UMLS:C1335689"
        ],
        "synonyms": [
          "rectal sarcomatoid cancer",
          "rectal sarcomatoid carcinoma",
          "rectal spindle cell carcinoma",
          "rectum sarcomatoid carcinoma",
          "sarcomatoid carcinoma of rectum",
          "sarcomatoid carcinoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A biphasic rectal carcinoma with a spindle cell, sarcomatoid component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004196"
    },
    {
      "id": 6501,
      "label": "rectum carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6478,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9174",
          "ICD10CM:D01.2",
          "ICD9:230.4",
          "MEDGEN:56335",
          "NCIT:C4853",
          "SCTID:308879003",
          "UMLS:C0154062",
          "icd11.foundation:1700649456"
        ],
        "synonyms": [
          "carcinoma in situ of rectum",
          "carcinoma in situ of the rectum",
          "marked dysplasia of rectum",
          "marked dysplasia of the rectum",
          "marked rectal dysplasia",
          "rectal carcinoma in situ",
          "rectum in situ carcinoma",
          "severe dysplasia of rectum",
          "severe dysplasia of the rectum",
          "severe rectal dysplasia",
          "stage 0 carcinoma of rectum",
          "stage 0 carcinoma of the rectum",
          "stage 0 rectal cancer",
          "stage 0 rectal cancer aJCC v6",
          "stage 0 rectal cancer aJCC v6 and v7",
          "stage 0 rectal cancer aJCC v7",
          "stage 0 rectal carcinoma",
          "stage 0 rectum carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the rectum."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004725"
    },
    {
      "id": 18545,
      "label": "squamous cell carcinoma of rectum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7726,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5528",
          "GARD:0021770",
          "MEDGEN:235534",
          "NCIT:C5554",
          "Orphanet:424002",
          "SCTID:766979005",
          "UMLS:C1335690"
        ],
        "synonyms": [
          "rectal squamous carcinoma",
          "rectal squamous cell cancer",
          "rectal squamous cell carcinoma",
          "rectum squamous cell carcinoma",
          "squamous carcinoma of rectum",
          "squamous carcinoma of the rectum",
          "squamous cell carcinoma of rectum",
          "squamous cell carcinoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A very rare rectal carcinoma characterized by the presence of a malignant squamous cell infiltrate."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018515"
    }
  ],
  "roots": [
    {
      "id": 8006,
      "label": "rectal cancer"
    },
    {
      "id": 21360,
      "label": "colorectal carcinoma"
    },
    {
      "id": 21431,
      "label": "epithelial neoplasm of rectum"
    }
  ]
}