{
  "id": 23521,
  "label": "congenital secretory diarrhea",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0045032",
  "properties": {
    "xrefs": [
      "ICD9:579.8",
      "MEDGEN:82757",
      "SCTID:25898005",
      "UMLS:C0267661"
    ],
    "synonyms": [
      "congenital secretory diarrhea"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 2794,
      "label": "secretory diarrhea",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050129",
          "HP:0005208",
          "MEDGEN:75635",
          "SCTID:15699003",
          "UMLS:C0267557"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption."
      },
      "child_count": 1,
      "reference_id": "MONDO:0000249"
    },
    {
      "id": 3147,
      "label": "congenital diarrhea",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3866,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060774",
          "MEDGEN:1877146",
          "OMIMPS:214700",
          "UMLS:C6013449"
        ],
        "synonyms": [
          "diarrhea, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 24,
      "reference_id": "MONDO:0000824"
    }
  ],
  "children": [
    {
      "id": 10222,
      "label": "congenital secretory chloride diarrhea 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060296",
          "GARD:0010001",
          "ICD9:579.8",
          "MEDGEN:78631",
          "MESH:C536210",
          "OMIM:214700",
          "Orphanet:53689",
          "SCTID:24412005",
          "UMLS:C0267662"
        ],
        "synonyms": [
          "SLC26A3 secretory diarrhea",
          "SLC26A3 secretory diarrhoea",
          "congenital chloridorrhea",
          "congenital secretory chloride diarrhea type 1",
          "congenital secretory chloride diarrhoea type 1",
          "secretory diarrhea caused by mutation in SLC26A3",
          "secretory diarrhoea caused by mutation in SLC26A3",
          "CLD",
          "Chloridorrhea, congenital",
          "DIAR1",
          "Darrow-gamble disease",
          "chloride diarrhea, congenital, Finnish type",
          "congenital chloride diarrhea",
          "congenital chloride diarrhoea",
          "diarrhea 1, secretory chloride, congenital",
          "diarrhoea 1, secretory chloride, congenital",
          "familial chloride diarrhea",
          "familial chloride diarrhoea"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Any secretory diarrhea in which the cause of the disease is a mutation in the SLC26A3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008964"
    },
    {
      "id": 10854,
      "label": "microvillus inclusion disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060775",
          "GARD:0007039",
          "ICD9:579.8",
          "MEDGEN:137954",
          "MedDRA:10068494",
          "NANDO:2100255",
          "NANDO:2200913",
          "NORD:1446",
          "OMIM:251850",
          "Orphanet:2290",
          "SCTID:235729009",
          "UMLS:C0341306",
          "icd11.foundation:2137578537"
        ],
        "synonyms": [
          "Davidson disease",
          "MVID",
          "MYO5B secretory diarrhea",
          "MYO5B secretory diarrhoea",
          "congenital familial protracted diarrhea with enterocyte brush-border abnormalities",
          "congenital familial protracted diarrhoea with enterocyte brush-border abnormalities",
          "congenital microvillous atrophy",
          "congenital microvillus atrophy",
          "diarrhoea 2 with microvillus atrophy",
          "microvillous inclusion disease",
          "microvillus inclusion disease",
          "secretory diarrhea caused by mutation in MYO5B",
          "secretory diarrhoea caused by mutation in MYO5B",
          "DIAR2",
          "Davidson's disease",
          "congenital familial protracted diarrhea",
          "congenital familial protracted diarrhea with enterocyte Brush-border abnormalities",
          "congenital familial protracted diarrhoea",
          "congenital familial protracted diarrhoea with enterocyte Brush-border abnormalities",
          "diarrhea 2, with microvillus atrophy",
          "diarrhoea 2, with microvillus atrophy",
          "familial enteropathy, microvillus",
          "intractable diarrhea of infancy",
          "intractable diarrhoea of infancy",
          "microvillus atrophy, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Microvillus inclusion disease (MVID) is a very rare, severe, malabsorbative syndrome characterized clinically by protracted or intractable neonatal secretory diarrhea and histologically by inclusion bodies on the intestinal epithelium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009635"
    },
    {
      "id": 11229,
      "label": "congenital secretory sodium diarrhea 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16096,
        23521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060781",
          "GARD:0018260",
          "MEDGEN:1778108",
          "OMIM:270420",
          "UMLS:C5441927"
        ],
        "synonyms": [
          "SPINT2 secretory diarrhea",
          "SPINT2 secretory diarrhoea",
          "congenital secretory sodium diarrhea type 3",
          "congenital secretory sodium diarrhoea type 3",
          "secretory diarrhea caused by mutation in SPINT2",
          "secretory diarrhoea caused by mutation in SPINT2",
          "DIAR3",
          "diarrhea 3, secretory sodium, congenital, syndromic",
          "diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies",
          "diarrhoea 3, secretory sodium, congenital, syndromic",
          "diarrhoea 3, secretory sodium, congenital, with or without other congenital anomalies",
          "sodium diarrhea, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Any secretory diarrhea in which the cause of the disease is a mutation in the SPINT2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010036"
    },
    {
      "id": 14220,
      "label": "congenital diarrhea 5 with tufting enteropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060776",
          "GARD:0010630",
          "MEDGEN:413031",
          "MESH:C567703",
          "OMIM:613217",
          "Orphanet:92050",
          "SCTID:715669000",
          "UMLS:C2750737",
          "icd11.foundation:1536004957"
        ],
        "synonyms": [
          "DIAR5",
          "EPCAM secretory diarrhea",
          "EPCAM secretory diarrhoea",
          "IED",
          "congenital diarrhea 5 with tufting enteropathy",
          "congenital tufting enteropathy",
          "intestinal epithelial dysplasia",
          "secretory diarrhea caused by mutation in EPCAM",
          "secretory diarrhoea caused by mutation in EPCAM",
          "tufting enteropathy",
          "congenital enteropathy",
          "congenital familial intractable diarrhea with enterocytes assembly abnormalities",
          "congenital familial intractable diarrhoea with enterocytes assembly abnormalities",
          "diarrhea 5, with tufting enteropathy, congenital",
          "diarrhoea 5, with tufting enteropathy, congenital",
          "enteropathy, congenital tufting",
          "intestinal epithelial cell dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Congenital Tufting Enteropathy is a rare congenital enteropathy presenting with early-onset severe and intractable diarrhea that leads to irreversible intestinal failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013184"
    },
    {
      "id": 15796,
      "label": "congenital secretory sodium diarrhea 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16096,
        23521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060777",
          "GARD:0018261",
          "MEDGEN:1783137",
          "OMIM:616868",
          "UMLS:C5441928"
        ],
        "synonyms": [
          "DIAR8",
          "SLC9A3 secretory diarrhea",
          "SLC9A3 secretory diarrhoea",
          "congenital secretory sodium diarrhea type 8",
          "congenital secretory sodium diarrhoea type 8",
          "diarrhea 8, secretory sodium, congenital",
          "diarrhoea 8, secretory sodium, congenital",
          "secretory diarrhea caused by mutation in SLC9A3",
          "secretory diarrhoea caused by mutation in SLC9A3",
          "diarrhea, congenital sodium"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Any secretory diarrhea in which the cause of the disease is a mutation in the SLC9A3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014808"
    }
  ],
  "roots": [
    {
      "id": 2794,
      "label": "secretory diarrhea"
    },
    {
      "id": 3147,
      "label": "congenital diarrhea"
    }
  ]
}