{
  "id": 23531,
  "label": "selective IgG immunodeficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0045045",
  "properties": {
    "xrefs": [
      "GARD:0025936",
      "MEDGEN:1618515",
      "NANDO:1200346",
      "NCIT:C27142",
      "SCTID:12631000119106",
      "UMLS:C4520847"
    ],
    "synonyms": [
      "selective IgG immunodeficiency",
      "IgG deficiency",
      "IgG subclass deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A broad classification of dysgammaglobulinemias characterized by low or undetectable serum levels of immunoglobulin class G (IgG). Deficiencies of IgG present variably according to subclass. IgG deficiencies are typically relative among subclasses and not absolute. Thus even with a given selective IgG subclass deficiency, total IgG levels may still fall within normal range. The clinical course and prognosis is dependent upon the severity of the deficiency and associated morbidity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3570,
      "label": "dysgammaglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11702",
          "GARD:0022925",
          "HP:0002961",
          "MEDGEN:41679",
          "MESH:D004406",
          "SCTID:123782009",
          "UMLS:C0013374"
        ],
        "synonyms": [
          "dysgammaglobulinemia",
          "dysgammaglobulinemia (disease)",
          "dysgammaglobulinemia (finding)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001342"
    }
  ],
  "children": [
    {
      "id": 4074,
      "label": "selective IgG subclass deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16461,
        23531
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14176",
          "GARD:0023033",
          "ICD9:279.03",
          "MEDGEN:56446",
          "MESH:D017099",
          "NCIT:C27024",
          "SCTID:190981001",
          "UMLS:C0162539"
        ],
        "synonyms": [
          "selective Immunoglobulin G subclass deficiency",
          "selective IgG deficiency disease",
          "selective IgG immunodeficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the four immunoglobulin class G (IgG) subclasses. Selective IgG1 deficiency is rare and primarily decreases the immune response to bacterial protein antigens. Selective IgG2 deficiency is the most common subclass deficiency among children and primarily leads to an inadequate response to bacterial polysaccharide antigens. Selective IgG3 deficiency is the most common subclass deficiency among adults and also primarily lowers the response to bacterial proteins. Selective IgG4 deficiency may be a clinically insignificant developmental variant, as IgG4 is a subclass that is virtually undetectable until the end of the first decade of life. Low levels of any IgG subclass will reduce the immune system's effectiveness and thus the clinical presentation of these diseases is usually recurrent infection, particularly by encapsulated bacteria."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001901"
    }
  ],
  "roots": [
    {
      "id": 3570,
      "label": "dysgammaglobulinemia"
    }
  ]
}