{
  "id": 23544,
  "label": "ACTH-producing pituitary gland neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0045058",
  "properties": {
    "xrefs": [
      "GARD:0025940",
      "MEDGEN:82997",
      "NCIT:C7909",
      "UMLS:C0278862"
    ],
    "synonyms": [
      "ACTH producing pituitary gland neoplasm",
      "ACTH-producing pituitary gland neoplasm",
      "ACTH-producing pituitary neoplasm",
      "ACTH-producing pituitary tumor",
      "ACTH-producing pituitary tumour",
      "ACTH-secreting tumor of pituitary",
      "ACTH-secreting tumor of the pituitary",
      "ACTH-secreting tumour of pituitary",
      "ACTH-secreting tumour of the pituitary",
      "adrenocorticotropin producing pituitary gland tumor",
      "adrenocorticotropin producing pituitary gland tumour",
      "adrenocorticotropin secreting neoplasm of pituitary",
      "adrenocorticotropin secreting neoplasm of the pituitary",
      "adrenocorticotropin secreting pituitary gland tumor",
      "adrenocorticotropin secreting pituitary gland tumour",
      "adrenocorticotropin secreting tumor of pituitary",
      "adrenocorticotropin secreting tumor of the pituitary",
      "adrenocorticotropin secreting tumour of pituitary",
      "adrenocorticotropin secreting tumour of the pituitary",
      "corticotropin secreting pituitary gland neoplasm",
      "pituitary corticotropin secreting neoplasm",
      "pituitary corticotropin secreting tumor",
      "pituitary corticotropin secreting tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma or carcinoma of the pituitary gland that produces corticotropin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    }
  ],
  "children": [
    {
      "id": 7648,
      "label": "ACTH-producing pituitary gland adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7896,
        23544
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000066",
          "GARD:0024280",
          "MEDGEN:266291",
          "NCIT:C7462",
          "UMLS:C1306214"
        ],
        "synonyms": [
          "ACTH producing pituitary gland adenoma",
          "ACTH secreting adenoma of pituitary",
          "ACTH secreting adenoma of the pituitary",
          "ACTH-producing pituitary adenoma",
          "ACTH-producing pituitary gland adenoma",
          "ACTH-secreting adenoma of pituitary",
          "ACTH-secreting adenoma of pituitary gland",
          "ACTH-secreting adenoma of the pituitary",
          "ACTH-secreting adenoma of the pituitary gland",
          "ACTHoma",
          "Corticotropinoma",
          "adrenocorticotropin producing adenoma of pituitary",
          "adrenocorticotropin producing adenoma of pituitary gland",
          "adrenocorticotropin producing adenoma of the pituitary",
          "adrenocorticotropin producing adenoma of the pituitary gland",
          "adrenocorticotropin producing pituitary adenoma",
          "adrenocorticotropin producing pituitary gland adenoma",
          "adrenocorticotropin secreting adenoma of pituitary",
          "adrenocorticotropin secreting adenoma of pituitary gland",
          "adrenocorticotropin secreting adenoma of the pituitary",
          "adrenocorticotropin secreting adenoma of the pituitary gland",
          "adrenocorticotropin secreting pituitary adenoma",
          "adrenocorticotropin secreting pituitary gland adenoma",
          "corticotroph adenoma",
          "corticotropic adenoma",
          "corticotropin secreting adenoma of the pituitary",
          "corticotropin secreting pituitary gland adenoma",
          "pituitary ACTH secreting adenoma",
          "pituitary ACTH-secreting adenoma",
          "pituitary corticotropin secreting adenoma",
          "pituitary gland ACTH-secreting adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006068"
    },
    {
      "id": 7649,
      "label": "ACTH-producing pituitary gland carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17862,
        23544
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6276",
          "EFO:1000067",
          "GARD:0024281",
          "MEDGEN:233657",
          "NCIT:C5964",
          "UMLS:C1334556"
        ],
        "synonyms": [
          "ACTH producing pituitary gland carcinoma",
          "malignant ACTH producing neoplasm of pituitary",
          "malignant ACTH producing neoplasm of pituitary gland",
          "malignant ACTH producing neoplasm of the pituitary",
          "malignant ACTH producing neoplasm of the pituitary gland",
          "malignant ACTH producing pituitary gland neoplasm",
          "malignant ACTH producing pituitary gland tumor",
          "malignant ACTH producing pituitary gland tumour",
          "malignant ACTH producing pituitary neoplasm",
          "malignant ACTH producing pituitary tumor",
          "malignant ACTH producing pituitary tumour",
          "malignant ACTH producing tumor of pituitary",
          "malignant ACTH producing tumor of pituitary gland",
          "malignant ACTH producing tumor of the pituitary",
          "malignant ACTH producing tumor of the pituitary gland",
          "malignant ACTH producing tumour of pituitary",
          "malignant ACTH producing tumour of pituitary gland",
          "malignant ACTH producing tumour of the pituitary",
          "malignant ACTH producing tumour of the pituitary gland",
          "malignant ACTH secreting neoplasm of pituitary",
          "malignant ACTH secreting neoplasm of pituitary gland",
          "malignant ACTH secreting neoplasm of the pituitary",
          "malignant ACTH secreting neoplasm of the pituitary gland",
          "malignant ACTH secreting pituitary gland tumor",
          "malignant ACTH secreting pituitary gland tumour",
          "malignant ACTH secreting pituitary neoplasm",
          "malignant ACTH secreting pituitary tumor",
          "malignant ACTH secreting pituitary tumour",
          "malignant ACTH secreting tumor of pituitary",
          "malignant ACTH secreting tumor of pituitary gland",
          "malignant ACTH secreting tumor of the pituitary",
          "malignant ACTH secreting tumor of the pituitary gland",
          "malignant ACTH secreting tumour of pituitary",
          "malignant ACTH secreting tumour of pituitary gland",
          "malignant ACTH secreting tumour of the pituitary",
          "malignant ACTH secreting tumour of the pituitary gland",
          "malignant Corticotropinoma of pituitary",
          "malignant Corticotropinoma of pituitary gland",
          "malignant Corticotropinoma of the pituitary",
          "malignant Corticotropinoma of the pituitary gland",
          "malignant adrenocorticotropin producing neoplasm of pituitary",
          "malignant adrenocorticotropin producing neoplasm of pituitary gland",
          "malignant adrenocorticotropin producing neoplasm of the pituitary",
          "malignant adrenocorticotropin producing neoplasm of the pituitary gland",
          "malignant adrenocorticotropin producing pituitary gland neoplasm",
          "malignant adrenocorticotropin producing pituitary gland tumor",
          "malignant adrenocorticotropin producing pituitary gland tumour",
          "malignant adrenocorticotropin producing pituitary neoplasm",
          "malignant adrenocorticotropin producing pituitary tumor",
          "malignant adrenocorticotropin producing pituitary tumour",
          "malignant adrenocorticotropin producing tumor of pituitary",
          "malignant adrenocorticotropin producing tumor of pituitary gland",
          "malignant adrenocorticotropin producing tumor of the pituitary",
          "malignant adrenocorticotropin producing tumor of the pituitary gland",
          "malignant adrenocorticotropin producing tumour of pituitary",
          "malignant adrenocorticotropin producing tumour of pituitary gland",
          "malignant adrenocorticotropin producing tumour of the pituitary",
          "malignant adrenocorticotropin producing tumour of the pituitary gland",
          "malignant adrenocorticotropin secreting pituitary gland neoplasm",
          "malignant adrenocorticotropin secreting pituitary gland tumor",
          "malignant adrenocorticotropin secreting pituitary gland tumour",
          "malignant adrenocorticotropin secreting pituitary neoplasm",
          "malignant adrenocorticotropin secreting pituitary tumor",
          "malignant adrenocorticotropin secreting pituitary tumour",
          "malignant corticotropin secreting pituitary gland neoplasm",
          "malignant pituitary Corticotropinoma",
          "malignant pituitary gland Corticotropinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces corticotropin. It may be associated with Cushing disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006069"
    }
  ],
  "roots": [
    {
      "id": 17888,
      "label": "pituitary tumor"
    }
  ]
}