{
  "id": 23656,
  "label": "meconium ileus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0054868",
  "properties": {
    "xrefs": [
      "MEDGEN:473705",
      "MESH:D000074270",
      "NCIT:C98979",
      "SCTID:206523001",
      "UMLS:C2939175"
    ],
    "synonyms": [
      "meconium ileus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Small intestinal obstruction that results from the impaction of thick meconium in the distal small intestine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6365,
      "label": "ileus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6363
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8440",
          "MEDGEN:219874",
          "MESH:D045823",
          "NCIT:C37979",
          "SCTID:710572000",
          "UMLS:C1258215"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Decrease in peristalsis in the absence of a mechanical bowel obstruction."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004567"
    }
  ],
  "children": [
    {
      "id": 7087,
      "label": "cystic fibrosis associated meconium ileus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23656,
        23838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004608",
          "MEDGEN:639765",
          "UMLS:C0546982"
        ],
        "synonyms": [
          "cystic fibrosis associated meconium ileum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Cystic fibrosis associated meconium ileum is a thickening and congestion of the meconium in the ileum in newborns, often the first sign of cystic fibrosis. In cystic fibrosis, the meconium can form a bituminous black-green mechanical obstruction in a segment of the ileum. Beyond this there may be a few separate grey-white globular pellets. Below this level, the bowel is a narrow and empty micro-colon. Above the level of the obstruction, there are several loops of hypertrophied bowel distended with fluid. No meconium is passed, and abdominal distension and vomiting appear soon after birth. About 20% of cases of cystic fibrosis present with meconium ileus, while approximately 20% of one series of cases of meconium ileus did not have cystic fibrosis. The presence of meconium ileus is not related to the severity of the cystic fibrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005413"
    },
    {
      "id": 14857,
      "label": "intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        20415,
        23656
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017418",
          "ICD9:777.1",
          "MEDGEN:1390359",
          "OMIM:614665",
          "Orphanet:314376",
          "SCTID:733447005",
          "UMLS:C4518781"
        ],
        "synonyms": [
          "meconium ileus",
          "GUCY2C meconium ileus",
          "meconium ileus caused by mutation in GUCY2C",
          "meconium ileus due to guanylate cyclase 2C deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Any meconium ileus in which the cause of the disease is a mutation in the GUCY2C gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013843"
    }
  ],
  "roots": [
    {
      "id": 6365,
      "label": "ileus"
    }
  ]
}