{
  "id": 23667,
  "label": "non-small cell squamous lung carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0056806",
  "properties": {
    "xrefs": [
      "DOID:0080521",
      "MEDGEN:1383559",
      "NCIT:C133254",
      "SCTID:723301009",
      "UMLS:C4509816"
    ],
    "synonyms": [
      "non-small cell squamous lung cancer",
      "non-small cell squamous lung carcinoma",
      "squamous non-small cell lung carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6824,
      "label": "squamous cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3907",
          "EFO:0000708",
          "ICD9:162.9",
          "MEDGEN:56202",
          "NCIT:C3493",
          "ONCOTREE:LUSC",
          "SCTID:254634000",
          "UMLS:C0149782"
        ],
        "synonyms": [
          "epidermoid cell carcinoma of lung",
          "epidermoid cell carcinoma of the lung",
          "epidermoid cell lung carcinoma",
          "lung squamous cell carcinoma",
          "squamous cell carcinoma of lung",
          "squamous cell carcinoma of the lung",
          "squamous cell lung cancer",
          "squamous cell lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005097"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3908",
          "EFO:0003060",
          "HP:0030358",
          "MEDGEN:40104",
          "MESH:D002289",
          "NCIT:C2926",
          "ONCOTREE:NSCLC",
          "Orphanet:488201",
          "SCTID:254637007",
          "UMLS:C0007131"
        ],
        "synonyms": [
          "NSCLC",
          "NSCLC - non-small cell lung cancer",
          "non-small cell cancer of lung",
          "non-small cell cancer of the lung",
          "non-small cell carcinoma of lung",
          "non-small cell carcinoma of the lung",
          "non-small cell lung cancer",
          "non-small cell lung carcinoma",
          "non-small cell lung carcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005233"
    }
  ],
  "children": [
    {
      "id": 6715,
      "label": "adenosquamous lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7652,
        23667
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4829",
          "EFO:0000233",
          "ICD9:162.9",
          "MEDGEN:79006",
          "NCIT:C9133",
          "ONCOTREE:LUAS",
          "SCTID:707405009",
          "UMLS:C0279557"
        ],
        "synonyms": [
          "adenosquamous cell lung carcinoma",
          "adenosquamous lung cancer",
          "adenosquamous lung carcinoma",
          "lung adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004973"
    }
  ],
  "roots": [
    {
      "id": 6824,
      "label": "squamous cell lung carcinoma"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma"
    }
  ]
}