{
  "id": 23765,
  "label": "secondary mast cell activation syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100006",
  "properties": {
    "xrefs": [
      "GARD:0026014",
      "ICD10CM:D89.43",
      "MEDGEN:1843472",
      "UMLS:C4267895"
    ],
    "synonyms": [
      "secondary MACS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Mast cell activation syndrome where an underlying inflammatory disease is present, often in the form of an IgE-dependent allergy, but there are no KIT-mutated mast cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 23764,
      "label": "mast cell activation syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012981",
          "MEDGEN:1698540",
          "MESH:D000090267",
          "UMLS:C5200989"
        ],
        "synonyms": [
          "MACS",
          "disorder of mast cell activation",
          "mast cell activation disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0100004"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 23764,
      "label": "mast cell activation syndrome"
    }
  ]
}