{
  "id": 23804,
  "label": "idiopathic mast cell activation syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100051",
  "properties": {
    "xrefs": [
      "GARD:0026026",
      "ICD10CM:D89.42",
      "MEDGEN:1786072",
      "UMLS:C4267894"
    ],
    "synonyms": [
      "idiopathic MACS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Mast cell activation syndrome where neither an allergy or other underlying disease is association, nor KIT-mutated mast cells are detectable."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 23764,
      "label": "mast cell activation syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012981",
          "MEDGEN:1698540",
          "MESH:D000090267",
          "UMLS:C5200989"
        ],
        "synonyms": [
          "MACS",
          "disorder of mast cell activation",
          "mast cell activation disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0100004"
    },
    {
      "id": 24405,
      "label": "idiopathic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29381
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:548250",
          "UMLS:C0277553"
        ],
        "synonyms": [
          "idiopathic disorder"
        ],
        "definition": "A disease or disorder for which the cause is of uncertain or unknown."
      },
      "child_count": 79,
      "reference_id": "MONDO:0700007"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 23764,
      "label": "mast cell activation syndrome"
    },
    {
      "id": 24405,
      "label": "idiopathic disease"
    }
  ]
}