{
  "id": 23805,
  "label": "anaphylaxis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100053",
  "properties": {
    "xrefs": [
      "MEDGEN:1373755",
      "MESH:D000707",
      "MedDRA:10002198",
      "NCIT:C107101",
      "SCTID:39579001",
      "UMLS:C4316895",
      "icd11.foundation:1868068711"
    ],
    "synonyms": [
      "anaphylactic shock",
      "systemic anaphylaxis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An acute hypersensitivity reaction that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    }
  ],
  "children": [
    {
      "id": 23806,
      "label": "idiopathic anaphylaxis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23805,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:595022",
          "SCTID:241954008",
          "UMLS:C0413235"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Idiopathic anaphylaxis is a rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100054"
    },
    {
      "id": 23808,
      "label": "exercise-induced anaphylaxis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23805
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006392",
          "MEDGEN:576137",
          "UMLS:C0344183",
          "icd11.foundation:1069179856"
        ],
        "synonyms": [
          "EIAn"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare disorder in which anaphylaxis occurs in association with physical activity."
      },
      "child_count": 1,
      "reference_id": "MONDO:0100056"
    }
  ],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    }
  ]
}