{ "id": 23869, "label": "vector-borne disease", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0100120", "properties": { "xrefs": [ "MEDGEN:738484", "MESH:D000079426", "UMLS:C1640363" ], "synonyms": [ "vector-borne infection", "vector-borne infectious disease" ], "definition": "An infectious disease where a pathogen is carried and transmitted by another organism that acts as disease vector." }, "isLeaf": false, "isRoot": false, "child_count": 49, "parents": [ { "id": 7200, "label": "infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 29383 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050117", "EFO:0005741", "ICD10CM:A00-B99", "ICD9:079.0", "ICD9:136.8", "ICD9:136.9", "IDO:0000436", "MEDGEN:1057", "MESH:D003141", "NCIT:C26726", "SCTID:40733004", "UMLS:C0009450" ], "synonyms": [ "communicable disease", "infection", "infectious", "infectious disease", "infectious diseases and manifestations", "infectious disorder", "transmissible disease", "clinical infection", "disease by infectious agent" ], "definition": "A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent in humans. It can be transmitted by direct or indirect contact." }, "child_count": 35, "reference_id": "MONDO:0005550" } ], "children": [ { "id": 2813, "label": "Whitewater Arroyo hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 6834, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050199" ], "definition": "A viral infectious disease that is a hemorrhagic fever, has material basis in Whitewater Arroyo virus, which is transmitted by white-throated woodrats (Neotoma albigula). The infection has symptom fever, has symptom headache, has symptom myalgia, and has symptom hemorrhagic manifestations." }, "child_count": 0, "reference_id": "MONDO:0000282" }, { "id": 2814, "label": "Hantavirus hemorrhagic fever with renal syndrome, Seoul virus type", "isLeaf": true, "isRoot": false, "parents": [ 7402, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050200", "GARD:0027517" ], "synonyms": [ "Korean hemorrhagic fever" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0000283" }, { "id": 2815, "label": "Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type", "isLeaf": true, "isRoot": false, "parents": [ 7402, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050201", "GARD:0027518", "MEDGEN:69308", "UMLS:C0242993" ], "synonyms": [ "nephropathis epidemica", "nephropathia epidemica" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0000284" }, { "id": 2835, "label": "Alkhurma hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 18095, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050308", "GARD:0022744", "MEDGEN:1684673", "UMLS:C5230236" ], "synonyms": [ "Alkhumra hemorrhagic fever virus caused disease or disorder", "Alkhumra hemorrhagic fever virus disease or disorder", "Alkhumra hemorrhagic fever virus infectious disease" ], "definition": "A disease caused by infection with Alkhumra hemorrhagic fever virus." }, "child_count": 0, "reference_id": "MONDO:0000310" }, { "id": 2856, "label": "O'nyong'nyong fever", "isLeaf": true, "isRoot": false, "parents": [ 7280, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050516", "GARD:0027520", "ICD10CM:A92.1", "MEDGEN:547234", "SCTID:85579005", "UMLS:C0276286" ], "synonyms": [ "O'nyong-nyong virus caused disease or disorder", "O'nyong-nyong virus disease or disorder", "O'nyong-nyong virus infectious disease" ], "definition": "An disease or disorder caused by infection with O'nyong-nyong virus." }, "child_count": 0, "reference_id": "MONDO:0000342" }, { "id": 2858, "label": "Ross river fever", "isLeaf": true, "isRoot": false, "parents": [ 7280, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050518", "GARD:0027522", "ICD10CM:B33.1", "MEDGEN:1673033", "SCTID:602001", "UMLS:C0919833", "icd11.foundation:1085418398" ], "synonyms": [ "Ross River virus caused disease or disorder", "Ross River virus disease", "Ross River virus disease or disorder", "Ross River virus infectious disease" ], "definition": "A disease caused by infection with Ross River virus." }, "child_count": 0, "reference_id": "MONDO:0000344" }, { "id": 2859, "label": "Oropouche fever", "isLeaf": true, "isRoot": false, "parents": [ 20697, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050521", "ICD10CM:A93.0", "MEDGEN:547314", "SCTID:72880002", "UMLS:C0276386", "icd11.foundation:693244560" ], "synonyms": [ "Oropouche virus caused disease or disorder", "Oropouche virus disease or disorder", "Oropouche virus infectious disease" ], "definition": "A disease caused by infection with Oropouche virus." }, "child_count": 0, "reference_id": "MONDO:0000345" }, { "id": 2860, "label": "Hantavirus hemorrhagic fever with renal syndrome, Dobrava-Belgrade virus type", "isLeaf": true, "isRoot": false, "parents": [ 7402, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050522", "GARD:0027523" ], "synonyms": [ "Balkan hemorrhagic fever" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0000346" }, { "id": 3170, "label": "Zika virus congenital syndrome", "isLeaf": true, "isRoot": false, "parents": [ 6834, 20719, 20721, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080180", "GARD:0013441", "MEDGEN:1622152", "UMLS:C4546023", "icd11.foundation:755611612" ], "synonyms": [ "congenital Zika syndrome", "congenital Zika virus infection" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" } ], "definition": "A congenital birth syndrome that arises from materal Zika infection." }, "child_count": 0, "reference_id": "MONDO:0000890" }, { "id": 3383, "label": "Murray valley encephalitis", "isLeaf": true, "isRoot": false, "parents": [ 7383, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10842", "ICD10CM:A83.4", "ICD9:062.4", "MEDGEN:509134", "SCTID:66454007", "UMLS:C0153066", "icd11.foundation:1040970454" ], "synonyms": [ "Australian X disease", "Australian encephalitis", "Murray Valley encephalitis virus caused disease or disorder", "Murray Valley encephalitis virus disease or disorder", "Murray Valley encephalitis virus infectious disease" ], "definition": "An disease caused by infection with Murray Valley encephalitis virus." }, "child_count": 0, "reference_id": "MONDO:0001137" }, { "id": 3436, "label": "spotted fever", "isLeaf": false, "isRoot": false, "parents": [ 8360, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11104", "EFO:1002047", "GARD:0019828", "ICD10CM:A77", "ICD9:082.0", "ICD9:083.8", "MEDGEN:1826170", "Orphanet:102022", "SCTID:186771002", "UMLS:C5680374", "icd11.foundation:9953620" ], "synonyms": [ "spotted fever", "spotted fever rickettsiae disease", "spotted fever rickettsiosis", "fever, spotted", "fevers, spotted", "spotted fever Group Rickettsioses", "spotted fever Group rickettsiosis", "spotted fevers" ], "definition": "A type of tick-borne disease which presents on the skin caused by bacteria of the genus Rickettsia." }, "child_count": 22, "reference_id": "MONDO:0001195" }, { "id": 3486, "label": "typhus", "isLeaf": false, "isRoot": false, "parents": [ 8360, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11256", "EFO:0009117", "GARD:0019829", "ICD10CM:A75", "ICD9:080", "ICD9:081.0", "ICD9:081.9", "MEDGEN:11976", "Orphanet:102023", "SCTID:240613006", "UMLS:C0041471", "icd11.foundation:292650041" ], "synonyms": [ "typhus fever", "typhus-group rickettsiae disease", "typhus-group rickettsiosis", "endemic flea-borne typhus", "endemic typhus fever", "epidemic louse-borne typhus", "exanthematic typhus fever", "flea typhus", "louse-borne [epidemic] typhus", "murine [endemic] typhus", "Moscow typhus", "classical typhus (fever)", "gaol fever" ], "definition": "A group of infectious diseases that include epidemic typhus, scrub typhus and murine typhus." }, "child_count": 6, "reference_id": "MONDO:0001246" }, { "id": 3662, "label": "Chagas disease", "isLeaf": true, "isRoot": false, "parents": [ 3209, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12140", "GARD:0018795", "ICD10CM:B57", "ICD10WHO:B57", "ICD9:086.2", "MEDGEN:11935", "MESH:D014355", "MedDRA:10001935", "NCIT:C84629", "Orphanet:3386", "SCTID:77506005", "UMLS:C0041234", "icd11.foundation:1365585570" ], "synonyms": [ "Chagas disease", "Chagas' disease", "Trypanosoma cruzi caused disease or disorder", "Trypanosoma cruzi disease or disorder", "Trypanosoma cruzi infectious disease", "infection by trypanosoma cruzi", "Chagas-mazza disease", "infection caused by trypanosoma cruzi", "south American trypanosomiasis" ], "definition": "A parasitic infection caused by Trypanosoma cruzi. It is transmitted by insect bites. It is characterized by an acute and chronic phase; in the acute phase patients may have fever, malaise, and swelling at the site of the insect bite. In the chronic phase patients develop hepatosplenomegaly, lymphadenopathy, cardiomyopathy and arrhythmias." }, "child_count": 0, "reference_id": "MONDO:0001444" }, { "id": 3665, "label": "lymphocytic choriomeningitis", "isLeaf": true, "isRoot": false, "parents": [ 7286, 8436, 21351, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12155", "GARD:0022945", "ICD10CM:A87.2", "ICD9:049.0", "MEDGEN:44220", "MESH:D008216", "UMLS:C0024266", "icd11.foundation:307264938" ], "synonyms": [ "lymphocytic meningitis", "lymphocytic choriomeningitis mammarenavirus caused infectious meningitis", "lymphocytic choriomeningitis mammarenavirus infectious meningitis", "lymphocytic meningoencephalitis" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A form of meningitis caused by lymphocytic choriomeningitis virus. mice and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ataxia, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal hydrocephalus, aqueductal stenosis, chorioretinitis, and microcephaly. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)" }, "child_count": 0, "reference_id": "MONDO:0001449" }, { "id": 3845, "label": "fungal esophagitis", "isLeaf": false, "isRoot": false, "parents": [ 3630, 4188, 23208, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13147", "ICD9:117.9", "MEDGEN:90960", "NCIT:C27107", "SCTID:235602008", "UMLS:C0341109" ], "synonyms": [ "fungal esophagitis" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "Infection of the esophagus caused by fungi, most often candida albicans and candida tropicalis. It usually affects patients with immunodeficiency disorders or diabetes mellitus. Symptoms include dysphagia and pain on swallowing." }, "child_count": 4, "reference_id": "MONDO:0001649" }, { "id": 4012, "label": "bacterial esophagitis", "isLeaf": true, "isRoot": false, "parents": [ 3630, 23208, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13921", "MEDGEN:83319", "NCIT:C27106", "SCTID:235601001", "UMLS:C0341108" ], "synonyms": [ "bacterial esophagitis" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "An acute bacterial infection that affects the esophagus. Symptoms include severe pain on swallowing and retrosternal pain. Endoscopic examination reveals esophageal mucosal ulcerations and pseudomembranous formations." }, "child_count": 0, "reference_id": "MONDO:0001832" }, { "id": 4396, "label": "West Nile fever", "isLeaf": false, "isRoot": false, "parents": [ 7383, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2366", "ICD10CM:A92.3", "ICD9:066.4", "ICD9:066.40", "MEDGEN:22705", "MESH:D014901", "SCTID:417093003", "UMLS:C0043124" ], "synonyms": [ "West Nile virus caused disease or disorder", "West Nile virus disease or disorder", "West Nile virus infectious disease" ], "definition": "A mosquito-borne viral illness caused by the west nile virus, a flavivirus and endemic to regions of Africa, Asia, and Europe. Common clinical features include headache; fever; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. meningitis; encephalitis; and myelitis may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)" }, "child_count": 2, "reference_id": "MONDO:0002282" }, { "id": 6860, "label": "malaria", "isLeaf": false, "isRoot": false, "parents": [ 4516, 23347, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12365", "EFO:0001068", "GARD:0006961", "ICD10CM:B53", "ICD9:084", "ICD9:084.6", "MEDGEN:7443", "MESH:D008288", "MedDRA:10025487", "NCIT:C34797", "NORD:1395", "Orphanet:673", "SCTID:61462000", "UMLS:C0024530", "icd11.foundation:1439886552" ], "synonyms": [ "plasmodiosis" ], "categories": [ { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly.Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired." }, "child_count": 21, "reference_id": "MONDO:0005136" }, { "id": 7118, "label": "human African trypanosomiasis", "isLeaf": false, "isRoot": false, "parents": [ 3209, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10112", "EFO:0005225", "GARD:0007826", "ICD9:086.5", "MEDGEN:21714", "MESH:D014353", "MedDRA:10001461", "NCIT:C84541", "Orphanet:3385", "SCTID:27031003", "UMLS:C0041228" ], "synonyms": [ "Africam sleeping sickness", "African trypanosomiasis", "sleeping sickness" ], "definition": "A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death." }, "child_count": 4, "reference_id": "MONDO:0005459" }, { "id": 7158, "label": "dengue disease", "isLeaf": false, "isRoot": false, "parents": [ 7383, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12205", "EFO:0005547", "GARD:0006254", "ICD10CM:A90", "ICD9:061", "MEDGEN:3721", "MESH:D003715", "MedDRA:10012310", "NCIT:C34528", "Orphanet:99828", "SCTID:38362002", "UMLS:C0011311" ], "synonyms": [ "DF", "Dengue", "Dengue fever", "Dengue virus caused disease or disorder", "Dengue virus disease or disorder", "Dengue virus infection", "Dengue virus infectious disease", "break bone fever", "Philippine hemorrhagic fever", "Singapore hemorrhagic fever", "Thai hemorrhagic fever", "hemorrhagic dengue" ], "definition": "Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS)." }, "child_count": 4, "reference_id": "MONDO:0005502" }, { "id": 7337, "label": "Colorado tick fever", "isLeaf": true, "isRoot": false, "parents": [ 7600, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4885", "GARD:0019042", "ICD10CM:A93.2", "ICD9:066.1", "MEDGEN:40398", "MESH:D003121", "MedDRA:10010022", "NORD:989", "Orphanet:83595", "SCTID:6452009", "UMLS:C0009400", "icd11.foundation:951357413" ], "synonyms": [ "American mountain fever", "Colorado tick encephalitis", "Colorado tick fever virus caused disease or disorder", "Colorado tick fever virus disease or disorder", "Colorado tick fever virus infectious disease", "Colorado tick-borne disease", "Mountain fever", "Mountain tick fever" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A febrile illness characterized by chills, aches, vomiting, leukopenia, and sometimes encephalitis. It is caused by the colorado tick fever virus, a reovirus transmitted by the tick Dermacentor andersoni." }, "child_count": 0, "reference_id": "MONDO:0005708" }, { "id": 7381, "label": "filarial elephantiasis", "isLeaf": true, "isRoot": false, "parents": [ 3994, 7094, 16705, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12211", "EFO:0007272", "GARD:0003321", "ICD9:374.83", "MEDGEN:8583", "MESH:D004605", "MedDRA:10016675", "NCIT:C128360", "NORD:1082", "Orphanet:2035", "SCTID:14100003", "SCTID:240820001", "UMLS:C0013884", "icd11.foundation:247221550" ], "synonyms": [ "Elephantiasis", "elephantiasis", "eyelid elephantiasis", "Bancroftian filariasis", "Malayi tropical eosinphilia", "Wuchereria Bancrofti infection", "Wuchereriasis" ], "categories": [ { "ref": "MONDO:0002022", "name": "disorder of orbital region" }, { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "Parasitic infestation of the human lymphatic system by wuchereria bancrofti or brugia malayi. It is also called lymphatic filariasis." }, "child_count": 0, "reference_id": "MONDO:0005761" }, { "id": 7434, "label": "Lassa fever", "isLeaf": true, "isRoot": false, "parents": [ 7287, 23423, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9537", "EFO:0007338", "GARD:0019688", "ICD10CM:A96.2", "ICD9:078.89", "MEDGEN:7276", "MESH:D007835", "MedDRA:10023927", "NCIT:C128418", "Orphanet:99824", "SCTID:19065005", "UMLS:C0023092", "icd11.foundation:515020316" ], "synonyms": [ "LF", "Lassa hemorrhagic fever" ], "definition": "A viral hemorrhagic fever that is caused by the Lassa virus, which is transmitted by contact with infected rodents; it is characterized by fever, headache, malaise, myalgia, and hearing loss." }, "child_count": 0, "reference_id": "MONDO:0005820" }, { "id": 7442, "label": "listeriosis", "isLeaf": false, "isRoot": false, "parents": [ 2837, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11573", "EFO:0007347", "GARD:0006915", "ICD10CM:A32", "ICD10WHO:A32", "ICD9:027.0", "MEDGEN:9788", "MESH:D008088", "MedDRA:10024641", "NCIT:C82994", "NORD:1375", "Orphanet:533", "UMLS:C0023860", "icd11.foundation:419706488" ], "synonyms": [ "Listeria infection", "Listeria monocytogenes caused disease or disorder", "Listeria monocytogenes disease or disorder", "Listeria monocytogenes infectious disease", "infection by Listeria monocytogenes", "Listeria monocytogenes infection" ], "definition": "A bacterial infection caused by Listeria monocytogenes. It occurs in newborns, elderly, and immunocompromised patients. The bacteria are transmitted through ingestion of contaminated food. Clinical manifestations include fever, muscle pain, respiratory distress, nausea, diarrhea, neck stiffness, irritability, seizures, and lethargy." }, "child_count": 2, "reference_id": "MONDO:0005828" }, { "id": 7474, "label": "Mycobacterium avium complex disease", "isLeaf": true, "isRoot": false, "parents": [ 2837, 20027, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2755", "EFO:0007386", "ICD9:031.8", "MEDGEN:6478", "MESH:D015270", "NCIT:C36197", "SCTID:373436002", "UMLS:C0026916" ], "synonyms": [ "Mycobacterium avium Complex", "Mycobacterium avium complex caused disease or disorder", "Mycobacterium avium complex disease or disorder", "Mycobacterium avium complex infectious disease", "Mycobacterium avium infection", "DMAC", "disseminated infection with mycobacterium avium complex" ], "definition": "An infection that is caused by Mycobacterium avium." }, "child_count": 0, "reference_id": "MONDO:0005866" }, { "id": 7515, "label": "phlebotomus fever", "isLeaf": true, "isRoot": false, "parents": [ 23869, 24062 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11360", "EFO:0007437", "ICD10CM:A93.1", "ICD9:066.0", "MEDGEN:14597", "MESH:D010217", "SCTID:407476002", "UMLS:C0030372" ], "synonyms": [ "Sandfly fever", "pappataci fever" ], "definition": "Influenza-like febrile viral disease caused by several members of the bunyaviridae family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii." }, "child_count": 0, "reference_id": "MONDO:0005913" }, { "id": 7583, "label": "trench fever", "isLeaf": true, "isRoot": false, "parents": [ 7299, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11101", "EFO:0007519", "GARD:0018862", "ICD10CM:A79.0", "ICD9:083.1", "MEDGEN:21637", "MESH:D014205", "MedDRA:10044582", "Orphanet:64694", "SCTID:82214002", "UMLS:C0040830", "icd11.foundation:1587737629" ], "synonyms": [ "Bartonella quintana caused disease or disorder", "Bartonella quintana disease or disorder", "Bartonella quintana infectious disease", "His-Werner disease", "Wolhynian fever", "bartonellosis due to Bartonella quintana infection", "quintan fever", "shin bone fever", "trench fever", "fever, trench", "fevers, trench", "trench fevers" ], "definition": "An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by bartonella quintana and transmitted by the human louse." }, "child_count": 0, "reference_id": "MONDO:0005991" }, { "id": 7596, "label": "Venezuelan equine encephalitis", "isLeaf": true, "isRoot": false, "parents": [ 6880, 7280, 18247, 21351, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9584", "EFO:0007534", "GARD:0006355", "ICD10CM:A92.2", "ICD9:066.2", "MEDGEN:4036", "MESH:D004685", "NCIT:C35121", "SCTID:417067005", "UMLS:C0014078", "icd11.foundation:608978790" ], "synonyms": [ "Venezuelan equine encephalitis virus caused disease or disorder", "Venezuelan equine encephalitis virus disease or disorder", "Venezuelan equine encephalitis virus infectious disease", "Venezuelan equine fever" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A condition caused by infection by the Venezuelan equine encephalitis virus, which is characterized by headache, fever, myalgia, nausea, and vomiting." }, "child_count": 0, "reference_id": "MONDO:0006005" }, { "id": 8372, "label": "rat-bite fever", "isLeaf": false, "isRoot": false, "parents": [ 6839, 23869 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1001144", "GARD:0009557", "ICD9:026.9", "MEDGEN:11123", "MESH:D011906", "MedDRA:10037904", "NCIT:C34971", "Orphanet:31205", "SCTID:1685005", "UMLS:C0034686", "icd11.foundation:1026551291" ], "synonyms": [ "Streptobacillosis", "spirillosis", "rat bite fever" ], "definition": "An infectious disease that is caused transmitted by the bite of a rat. Two species of bacteria can cause the infection: Streptobacillus moniliformis and Spirillum minus." }, "child_count": 4, "reference_id": "MONDO:0006941" }, { "id": 13060, "label": "leishmaniasis", "isLeaf": false, "isRoot": false, "parents": [ 4516, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9065", "EFO:0005044", "GARD:0006881", "ICD10CM:B55", "ICD10WHO:B55", "ICD9:085", "ICD9:085.9", "MEDGEN:9714", "MESH:D007896", "MedDRA:10024198", "NCIT:C34767", "NORD:1895", "Orphanet:507", "SCTID:80612004", "UMLS:C0023281", "icd11.foundation:1082373067" ], "synonyms": [ "cutaneous leishmaniasis (subtype)", "visceral leishmaniasis (subtype)" ], "definition": "Infectious disease that is transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration)." }, "child_count": 6, "reference_id": "MONDO:0011989" }, { "id": 16140, "label": "schistosomiasis", "isLeaf": false, "isRoot": false, "parents": [ 6448, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1395", "EFO:1001475", "GARD:0009687", "ICD10CM:B65", "ICD9:120.8", "ICD9:120.9", "MEDGEN:48573", "MESH:D012552", "MedDRA:10039603", "NCIT:C35000", "Orphanet:1247", "SCTID:10087007", "UMLS:C0036323", "icd11.foundation:1194562592" ], "synonyms": [ "Bilharzia", "bilharziasis", "schistosomiasis", "snail fever" ], "definition": "An infectious disease caused by parasitic trematodes of the genus Schistosoma that colonize human blood vessels and release eggs that can cause granulomatous reactions leading to acute (swimmer's itch or acute schistosomiasis syndrome) or chronic disease. Depending on where the eggs lodge, manifestations of chronic schistosomiasis can include diarrhea, abdominal pain, loss of appetite, anemia (intestines), hepatosplenism, periportal fibrosis with portal hypertension (liver), urogenital inflammation and scarring, hematuria and dysuria (genitourinary system). Other patients may be asymptomatic." }, "child_count": 14, "reference_id": "MONDO:0015254" }, { "id": 17497, "label": "onchocerciasis", "isLeaf": false, "isRoot": false, "parents": [ 7539, 16705, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11678", "EFO:0007402", "GARD:0007252", "ICD10CM:B73", "ICD10WHO:B73", "ICD9:125.3", "MEDGEN:14477", "MESH:D009855", "MedDRA:10030314", "MedDRA:10039202", "NCIT:C34861", "Orphanet:2737", "SCTID:38539003", "UMLS:C0029001", "icd11.foundation:106136071" ], "synonyms": [ "Onchocerca volvulus infection", "infection by Onchocerca volvulus", "onchocerciasis", "River blindness", "Robles' disease", "infection caused by Onchocerca volvulus", "onchocercosis" ], "definition": "Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy." }, "child_count": 3, "reference_id": "MONDO:0017137" }, { "id": 18088, "label": "Argentine hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 7287, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050194", "GARD:0021411", "ICD10CM:A96.0", "MEDGEN:9211", "Orphanet:319223", "SCTID:58868000", "UMLS:C0019097", "icd11.foundation:257166193" ], "synonyms": [ "Argentinian hemorrhagic fever", "Junin hemorrhagic fever" ], "definition": "Argentine hemorrhagic fever (AHF), caused by the Junin virus (JUNV), is an acute viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms and in some cases hemorrhagic and neurological manifestations." }, "child_count": 0, "reference_id": "MONDO:0017874" }, { "id": 18089, "label": "Bolivian hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 18247, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050195", "GARD:0021412", "ICD10CM:A96.1", "MEDGEN:76386", "MedDRA:10005932", "Orphanet:319229", "SCTID:67247008", "UMLS:C0282192", "icd11.foundation:1780467429" ], "synonyms": [ "Machupo hemorrhagic fever" ], "definition": "Bolivian hemorrhagic fever (BHF), caused by the Machupo virus (MACV), is a severe acute viral hemorrhagic fever characterized by fever, myalgia, and arthralgia followed by hemorrhagic and neurological manifestations." }, "child_count": 0, "reference_id": "MONDO:0017875" }, { "id": 18090, "label": "Venezuelan hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 18247, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050196", "GARD:0021413", "MEDGEN:508283", "Orphanet:319234", "SCTID:359673001", "UMLS:C0042470", "icd11.foundation:356743940" ], "synonyms": [ "Guanarito hemorrhagic fever" ], "definition": "Venezuelan hemorrhagic fever (VHF), caused by the Guanarito virus, is a viral hemorrhagic disease characterized by fever, headache, arthralgia, sore throat, convulsions, and hemorrhagic manifestations." }, "child_count": 0, "reference_id": "MONDO:0017876" }, { "id": 18093, "label": "hantavirus pulmonary syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4370, 6971, 7400, 18247, 21376, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:14472", "EFO:0007296", "GARD:0000069", "ICD9:480.8", "MEDGEN:66205", "MESH:D018804", "MedDRA:10019143", "NCIT:C84747", "NORD:1216", "Orphanet:319247", "SCTID:120639003", "UMLS:C0243025", "icd11.foundation:582624609" ], "synonyms": [ "HARDS", "Hantavirus", "Hantavirus-associated respiratory distress syndrome", "four corners hantavirus" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "An infection caused by Hantaviruses. It manifests with flu-like symptoms but it rapidly progresses to life-threatening respiratory problems." }, "child_count": 0, "reference_id": "MONDO:0017879" }, { "id": 18094, "label": "Rift valley fever", "isLeaf": true, "isRoot": false, "parents": [ 18247, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1328", "GARD:0021416", "ICD10CM:A92.4", "MEDGEN:20589", "MESH:D012295", "MedDRA:10039143", "NCIT:C128419", "Orphanet:319251", "SCTID:402917003", "UMLS:C0035613", "icd11.foundation:854137188" ], "synonyms": [ "RVF" ], "definition": "Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms." }, "child_count": 0, "reference_id": "MONDO:0017880" }, { "id": 18140, "label": "chikungunya", "isLeaf": true, "isRoot": false, "parents": [ 7280, 18253, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050012", "GARD:0006038", "MEDGEN:3362", "MESH:D065632", "NCIT:C128422", "NORD:924", "Orphanet:324625", "SCTID:111864006", "UMLS:C0008055", "icd11.foundation:900389391" ], "synonyms": [ "Chikungunya fever", "Chikungunya virus caused disease or disorder", "Chikungunya virus disease or disorder", "Chikungunya virus infectious disease", "CHIK", "CHIKV infection", "CK", "Chikungunya virus infection", "arbovirus A Chikungunya type" ], "definition": "An infection that is caused by the Chikungunya virus, which is transmitted by mosquitoes; it is characterized by fever and severe arthralgia." }, "child_count": 0, "reference_id": "MONDO:0017941" }, { "id": 18238, "label": "tularemia", "isLeaf": false, "isRoot": false, "parents": [ 2837, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2123", "EFO:1001444", "GARD:0000396", "ICD10CM:A21", "ICD9:021.8", "ICD9:021.9", "MEDGEN:22520", "MESH:D014406", "MedDRA:10045146", "NCIT:C85208", "NORD:1803", "Orphanet:3392", "SCTID:19265001", "UMLS:C0041351" ], "synonyms": [ "Francisella tularensis caused disease or disorder", "Francisella tularensis disease or disorder", "Francisella tularensis infectious disease", "Deerfly fever", "Francisella tularensis infection", "Ohara disease", "Pahvant Valley plague", "Yatobyo (Japan)", "lemming fever", "rabbit fever" ], "definition": "Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics." }, "child_count": 12, "reference_id": "MONDO:0018077" }, { "id": 18653, "label": "Zika virus infectious disease", "isLeaf": true, "isRoot": false, "parents": [ 7383, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060478", "GARD:0012894", "ICD10CM:A92.5", "MEDGEN:547236", "MESH:D000071243", "NCIT:C128423", "Orphanet:448237", "SCTID:3928002", "UMLS:C0276289", "icd11.foundation:1401438580" ], "synonyms": [ "ZikV infection", "Zika", "Zika virus caused disease or disorder", "Zika virus disease", "Zika virus disease or disorder", "Zika virus infection", "Zika virus infectious disease", "congenital Zika syndrome", "congenital Zika virus infection", "Zika fever", "fever, Zika" ], "definition": "Mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy." }, "child_count": 0, "reference_id": "MONDO:0018661" }, { "id": 18984, "label": "plague", "isLeaf": false, "isRoot": false, "parents": [ 2837, 8443, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3482", "EFO:0009425", "GARD:0018702", "ICD10CM:A20", "ICD10WHO:A20", "ICD9:020", "ICD9:020.9", "ICD9:136.8", "MEDGEN:10785", "MESH:D010930", "MedDRA:10035148", "MedDRA:10061416", "NCIT:C85015", "NORD:1583", "Orphanet:707", "SCTID:58750007", "UMLS:C0032064", "icd11.foundation:1596449540" ], "synonyms": [ "Yersiniosis", "plague", "black death", "infection by Yersinia pestis", "pest", "pestilential fever" ], "definition": "Plague is a severe bacterial infection caused by the gram-negative bacterium Yersinia pestis." }, "child_count": 9, "reference_id": "MONDO:0019095" }, { "id": 19056, "label": "Q fever", "isLeaf": true, "isRoot": false, "parents": [ 2837, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11100", "EFO:0005224", "GARD:0007515", "ICD10CM:A78", "ICD10WHO:A78", "ICD9:083.0", "MEDGEN:48290", "MESH:D011778", "MedDRA:10037688", "MedDRA:10037731", "NCIT:C34970", "NORD:1643", "Orphanet:781", "SCTID:186788009", "UMLS:C0034362", "icd11.foundation:2113860626" ], "synonyms": [ "Coxiella burnetii caused disease or disorder", "Coxiella burnetii disease or disorder", "Coxiella burnetii infectious disease", "Coxiellosis", "infection due to Coxiella burnetii", "nine Mile fever", "quadrilateral fever", "query fever", "Coxiella burnetii fever", "Q fever pneumonia" ], "definition": "A bacterial infection caused by Coxiella burnetii. It is transmitted to humans by the inhalation of infected air particles or contact with fluids and feces of infected animals. Signs and symptoms include the abrupt onset of fever, headache, myalgias, and weakness." }, "child_count": 0, "reference_id": "MONDO:0019186" }, { "id": 19316, "label": "tungiasis", "isLeaf": true, "isRoot": false, "parents": [ 4888, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050266", "EFO:1001445", "GARD:0000393", "ICD10CM:B88.1", "ICD9:134.1", "MEDGEN:78823", "MESH:D058285", "Orphanet:879", "SCTID:64612002", "UMLS:C0277356", "icd11.foundation:2076748409" ], "synonyms": [ "Tunga penetrans caused disease or disorder", "Tunga penetrans disease or disorder", "Tunga penetrans infectious disease", "S penetrans", "Sarcopsylla penetrans", "T penetrans", "Tunga penetrans", "chigger flea" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "An disease or disorder caused by infection with Tunga penetrans." }, "child_count": 0, "reference_id": "MONDO:0019498" }, { "id": 19423, "label": "relapsing fever", "isLeaf": false, "isRoot": false, "parents": [ 2837, 8148, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13034", "GARD:0019171", "ICD10CM:A68", "ICD9:087", "ICD9:087.9", "MEDGEN:48397", "MESH:D012061", "MedDRA:10038300", "Orphanet:91547", "SCTID:420079008", "UMLS:C0035021", "icd11.foundation:965498095" ], "definition": "Relapsing fever is an infection caused by bacteria of the genus Borrelia, excluding those responsible for Lyme disease belonging to the Borrelia burgdorferi complex." }, "child_count": 6, "reference_id": "MONDO:0019633" }, { "id": 19954, "label": "Crimean-Congo hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 18247, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12287", "GARD:0019690", "ICD10CM:A98.0", "ICD9:065.0", "MEDGEN:6800", "MESH:D006479", "NCIT:C34682", "Orphanet:99827", "SCTID:402919000", "UMLS:C0019099", "icd11.foundation:1562906700" ], "synonyms": [ "CCHF", "Congo fever", "Congo hemorrhagic fever", "Congo-Crimean hemorrhagic fever", "Crimean hemorrhagic fever", "Crimean hemorrhagic fever [CHF Congo virus]", "Crimean-Congo haemorrhagic fever" ], "definition": "Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure." }, "child_count": 0, "reference_id": "MONDO:0020501" }, { "id": 19955, "label": "yellow fever", "isLeaf": true, "isRoot": false, "parents": [ 7383, 18253, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9682", "GARD:0007914", "ICD10CM:A95", "ICD10WHO:A95", "ICD9:060", "ICD9:060.9", "MEDGEN:53112", "MESH:D015004", "MedDRA:10048240", "NCIT:C35547", "NORD:1873", "Orphanet:99829", "UMLS:C0043395", "icd11.foundation:383352795" ], "synonyms": [ "YF", "Yellow Jack", "Yellow fever Virus infection", "Yellow fever virus caused disease or disorder", "Yellow fever virus disease or disorder", "Yellow fever virus infectious disease", "bronze John", "sylvatic yellow fever" ], "definition": "Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure." }, "child_count": 0, "reference_id": "MONDO:0020502" }, { "id": 20036, "label": "mosquito-borne viral encephalitis", "isLeaf": false, "isRoot": false, "parents": [ 7600, 23869 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025184", "ICD10CM:A83", "ICD10WHO:A83", "MEDGEN:152945", "NCIT:C34823", "UMLS:C0751098" ], "synonyms": [ "mosquito-borne viral encephalitis" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Viral encephalitis that is transmitted by mosquitos." }, "child_count": 10, "reference_id": "MONDO:0020601" }, { "id": 20137, "label": "arbovirus infection", "isLeaf": true, "isRoot": false, "parents": [ 6834, 23869 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1001269", "MEDGEN:389", "MESH:D001102", "NCIT:C34396", "SCTID:40610006", "UMLS:C0003723" ], "synonyms": [ "arbovirus infection", "arthropod-borne viral infection", "ARBOVIRUS INFECT", "Arboviral disease", "Arbovirus Infection", "Arbovirus Infections", "Arbovirus infection", "Arthropod-Borne Viral Infection", "Arthropod-borne viral infection", "Infection, Arbovirus", "Infections, Arbovirus" ], "definition": "A viral infection that is transmitted by an arthropod." }, "child_count": 0, "reference_id": "MONDO:0020731" }, { "id": 21670, "label": "tick-borne infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 23869 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:56488", "MESH:D017282", "UMLS:C0162700" ], "synonyms": [ "Tick borne diseases", "Tick borne infections", "Tick-borne disease", "Tick-borne infection", "Tick-borne infections", "disease, Tick-borne", "diseases, Tick-borne", "infection, Tick-borne", "infections, Tick borne", "infections, Tick-borne" ], "definition": "Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic." }, "child_count": 10, "reference_id": "MONDO:0025294" } ], "roots": [ { "id": 7200, "label": "infectious disease" } ] }